Renal clear cancer cells regulate the differentiation of urine‐derived stem cells to carcinoma‐associated fibroblasts via RUNX3/TGF‐β1 signaling axis

Abstract

Clear cell renal cell carcinoma (ccRCC), the most common pathological subtype of renal cancer, is one of the significant health concerns due to limited clinically effective treatments. Nevertheless, targeting carcinoma-associated fibroblasts in the tumor microenvironment has emerged as a promising innovative strategy for renal cancer | 1627

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

“…The investigation of USCs in oncology may still be in its early stages. Although fewer studies have explored the relationship between USCs and tumor diseases, research conducted by Chen et al has revealed that renal clear cell carcinoma cells can influence the differentiation of USCs into carcinoma-associated fibroblasts through the RUNX3/TGF-β1 signaling axis [ 106 ]. Luo et al's study utilized sequencing and biological analyses to reveal that urinary-derived stem cells (USCs) derived from clear cell renal cell carcinoma (ccRCC) patients exhibited heightened proliferative and invasive capabilities.…”