Renal-Clip Hypertension in Rabbits Immunised Against Angiotensin Ii

Wj, Louis; Renzini, V.; Macdonald, Graham; Boyd, G. W.; Peart, W. S.

doi:10.1016/s0140-6736(70)90707-5

Cited by 32 publications

(5 citation statements)

References 5 publications

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“…The resistance of hypertension to immunization against angiotensin I1 has been adduced as powerful evidence against participation of circulating angiotensin in the underlying haemodynamic mechanisms (Eide & Aars, 1969;Louis, Macdonald, Renzini, Boyd & Peart, 1970). The present observations suggest a possible alternative role for angiotensin which is independent of circulatory levels.…”

Section: Discussionsupporting

confidence: 49%

Generation of Angiotensin II at Peripheral Vascular Level: Studies Using Angiotensin II Antisera

Swales

Thurston

1973

Clinical Science

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1. When the renin-angiotensin system of rats had been suppressed by a high salt diet or by bilateral nephrectomy, large doses of angiotensin I1 antiserum were required to block the pressor action of exogenous angiotensin 11. Infusion of renin profoundly lowered the blocking requirement of such animals.2. It is postulated that renin bound to blood vessels generates angiotensin locally which is taken up by vascular receptors. Where such receptors are left unoccupied and free to bind exogenous angiotensin, high doses of blocking antisera are required.3. Animals with hypertension produced by renal artery constriction with contralateral nephrectomy were shown to be in positive sodium balance. Nevertheless their blocking requirement was low.4. It is suggested that the local generation of angiotensin may play a role in the production of renal hypertension and that this accounts for the development of hypertension even in animals immunized against angiotensin.Key words : angiotensin I1 antiserum, renin, sodium depletion and sodium loading, pressor response, clip-nephrectomy hypertension, bilateral nephrectomy.Most studies of the role of the renin-angiotensin system in hypertension depend upon circulating renin and angiotensin I1 levels, which do not necessarily represent the concentration of these substances at the vascular receptor site. Brunner, Chang, Wallach, Sealey & Laragh (1972) measured the amount of angiotensin I1 antibody required to block the blood pressure response to exogenous angiotensin I1 in the rat. Where the endogenous formation of renin and angiotensin I1 had been stimulated by a low salt diet, the pressor response to 50 ng doses of exogenous angiotensin I1 was blocked by very small doses of antiserum. Conversely, where the renin-angiotensin system had been suppressed by a high salt intake, large amounts of antiserum were required. To explain this anomaly, they suggest that vascular affinity for

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Section: Discussionsupporting

confidence: 49%

Generation of Angiotensin II at Peripheral Vascular Level: Studies Using Angiotensin II Antisera

Swales

Thurston

1973

Clinical Science

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“…Recent reports on the failure to affect experimentally induced renal hypertension in rab'bits by immunization against A-I1 (8,15) have raised the question whether A-I1 has any role in the development of renal hypertension. On the other hand many recent reports suggest several possible mechanisms whereby A-I1 and its congeners could affect the systemic blood pressure, e.g.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin Ii Plasma Levels in Hypertensive Patients

Fyhrquist

Kala

Standertskiöld‐Nordenstam

et al. 1972

Journal of Internal Medicine

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The response of peripheral venous plasma angiotensin II (A‐II) to upright posture combined with an injection of furosemide was higher in patients with hypertension and associated renal parenchymal disease, renal artery stenosis or malignant hypertension than in patients with essential hypertension and normotensive control patients. Very low responses to the same stimuli were observed in primary aldosteronism. Markedly increased A‐II levels were measured in the renal veins of the affected kidneys in hypertensive patients with associated unilateral renal parenchymal disease or renal artery stenosis, suggesting that human kidneys contain considerable converting enzyme activity. Plasma A‐II levels were normalized in three patients with primary aldosteronism after removal of an adrenal adenoma and in one patient with malignant hypertension after bilateral nephrectomy and renal transplantation.

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“…It was shown that prior immunization against angiotensin II in the rabbit does not prevent the development of renal-clip hypertension, and that immunization of rabbits already hypertensive does not lower blood pressure. A preliminary account of this work has been reported previously (15).…”

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confidence: 95%

Renal-Clip Hypertension in Rabbits Immunized Against Angiotensin II

Macdonald

Louis

Renzini

et al. 1970

Circulation Research

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The rabbit immunized against angiotensin II was shown to be a valid model for the study of renal-clip hypertension. In particular, there was a specific and complete blockade of the pressor effect of high doses of intravenous renin and angiotensin in vivo, even at angiotensin II production rates which far exceeded those associated with renal-clip hypertension. Despite this, four immunized rabbits developed hypertension after renal-artery clipping with contralateral nephrectomy, and in three of these the hypertension was severe. In four other rabbits, there was no evidence of modification of an established hypertension after immunization against angiotensin II. In both groups, the specific absence of pressor response to high doses of renin and angiotensin II after immunization was confirmed. These studies provide strong evidence that angiotensin is not the sole or even the major factor in either the initiation or maintenance of this form of hypertension. ADDITIONAL KEY WORDSrenin plasma angiotensin radioimmunoassay angiotensin II production rate noradrenal i ne metabolic clearance rate antibody-bound angiotensin II

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Renal-Clip Hypertension in Rabbits Immunised Against Angiotensin Ii

Cited by 32 publications

References 5 publications

Generation of Angiotensin II at Peripheral Vascular Level: Studies Using Angiotensin II Antisera

Generation of Angiotensin II at Peripheral Vascular Level: Studies Using Angiotensin II Antisera

Angiotensin Ii Plasma Levels in Hypertensive Patients

Renal-Clip Hypertension in Rabbits Immunized Against Angiotensin II

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