Renal contribution to thoracic duct lymph in dogs

O’Morchoe, C. C. C.; O'Morchoe, Patricia J.

doi:10.1113/jphysiol.1968.sp008409

Cited by 10 publications

(2 citation statements)

References 11 publications

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“…By the same method, unilateral renal lymph flow can be estimated from the values reported here at 0.5 to 0.6 ml/hour/kg body weight. This is in close agreement with the value of 0.56 ml/hour/kg obtained by a different method in a previous study (1). In both studies the intravenous infusion rates were comparable and renal lymph flow was found to be related to body weight.…”

Section: Figuresupporting

confidence: 92%

Renal Hilar Lymph

O’Morchoe

O'Morchoe

Heney

1970

Circulation Research

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Renal lymph was collected from single hilar lymphatics in 58 anesthetized dogs (1) to study the mechanism by which lymph production is affected during diuresis and (2) to determine whether a medullary contribution to renal lymph could be defined by changes in the electrolyte concentration of hilar lymph with concomitant alterations in the concentration gradient of the renal medulla. When diuresis was induced by a solute load (mannitol), lymph flow increased by 25 to 300%. On the other hand, when diuresis was induced without such a solute load, lymph flow was either unaffected (mersalyl) or slightly reduced (furosemide). It was concluded that the effect of mannitol on renal lymph flow was mediated primarily through its general eSect on extracellular fluid rather than through any specific intrarenal consequence of the diuresis itself.Control hilar lymph-to-plasma concentration ratios for Na + (1.057 ± 0.040), Ch (1.129 ± 0.040) and Ca 2+ (0.770 ± 0.046) but not K+ (0.986 ± 0.086) were found to be significantly different from 1.0. Failure of mannitol diuresis to alter significantly the lymph-plasma ratios of Na + and Ch~ provided evidence that the high electrolyte concentrations of the inner medulla were not reflected in hilar lymph. The finding that furosemide abolished the lymph-plasma concentration difference for Na + and significantly reduced that for Ch was taken as evidence that the outer medulla was a significant source of renal hilar lymph. Received October 9, 1969. Accepted for publication February 3, 1970. from the decrease in thoracic duct lymph which followed cessation of renal lymph production (1, 2). This method is not, however, suitable for comparison of flow under differing conditions in the same animal, nor does it provide information on changes in the composition of renal lymph. To obtain such information in the present study, renal lymph was collected by cannulating single hilar lymphatics in dogs. ADDITIONALWhile there is evidence that the flow of renal lymph is augmented during the administration of certain diuretics (2-5), the mechanism by which this is brought about has not been studied. Since the infusion of a solute load itself can alter the general level of lymph formation throughout the body, it is apparent that the effect on lymph production by the kidney might not be a specific" consequence of

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Section: Figuresupporting

confidence: 92%

Renal Hilar Lymph

O’Morchoe

O'Morchoe

Heney

1970

Circulation Research

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“…Bull & Metaxas (1962) stripped the kidney from its surrounding tissue attachments and after placing the kidney in a basin they collected the fluid oozing from the cut lymphatics. O'Morchoe & O'Morchoe (1968) calculated renal lymph flow rates in the dog by measuring the rate of thoracic duct flow before and after ligating the renal artery. The fall in the thoracic duct flow that followed this procedure was considered to be the rate of renal lymph production.…”

Section: Introductionmentioning

confidence: 99%

The lymphatics of the kidney and the formation of renal lymph

McIntosh¹,

Morris²

1971

The Journal of Physiology

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SUMIARY1. The anatomy of the renal lymphatics and the flow and composition of renal lymph have been investigated in sheep. Lymphatic capillaries were demonstrated in the cortex and cortico-medullary areas of the sheep's kidney but not within the medulla. The lymph formed in the sheep's kidney drains from the hilum through several small lymphatics; there is no lymphatic drainage from the renal capsule.2. Lymph flow from the sheep's kidney varied from 05 to 3 0 ml./hr. The concentrations of electrolytes and urea in renal lymph were found to be similar to lymph from other regions of the body, but the concentration of endogenous creatinine was lower. The average concentration of protein in renal lymph was 43 % of the plasma levels; there was a significantly higher proportion of albumin in renal lymph than in plasma. When labelled albumin was injected intravenously, the specific activities of the plasma and renal lymph albumin equilibrated in about 2 hr. [1251]hippuran the ratio was 034. It was considered that the concentration of these substances in renal lymph was similar to the concentration in renal vein plasma.4. The concentration of renin enzyme was on the average about 8 times higher in renal lymph than in jugular vein or renal vein plasma or in lymph from the hind limbs.5. Renal lymph appeared to be formed principally, if not entirely, in the renal cortex and appeared to be a modified filtrate derived from post-

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Kidney Lymphatics

Russell

Itkin

Windsor

et al. 2023

Comprehensive Physiology

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Following significant advances in lymphatic biology, the important role of kidney lymphatics in kidney function and dysfunction is now being more fully appreciated. Kidney lymphatics begin in the cortex as blind-ended lymphatic capillaries and then coalesce into larger lymphatics that follow the main blood vessels out through the kidney hilum. Their function in draining interstitial fluid, macromolecules, and cells underpins their important role in kidney fluid and immune homeostasis. This article provides a comprehensive overview of recent and more established research findings on kidney lymphatics and the implications of these findings for kidney function and disease. The use of lymphatic molecular markers has greatly expanded our knowledge of the development, anatomy, and pathophysiology of kidney lymphatics. Significant recent discoveries include the diverse embryological source of kidney lymphatics, the hybrid nature of the ascending vasa recta, and the effects of lymphangiogenesis on kidney diseases such as acute kidney injury and renal fibrosis. On the basis of these recent advances, there is now an opportunity to link information from across multiple research disciplines to drive a new era of lymphatic-targeted therapies for kidney disease.

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Renal contribution to thoracic duct lymph in dogs

Cited by 10 publications

References 11 publications

Renal Hilar Lymph

Renal Hilar Lymph

The lymphatics of the kidney and the formation of renal lymph

Kidney Lymphatics

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