Renal damage in the metabolic syndrome (MetSx): Disorders implicated

Trujillo, Joyce; Chirino, Yolanda I.; Martínez-Tagüeña, Natalia; Pedraza-Chaverri, José

doi:10.1016/j.ejphar.2017.11.032

Cited by 24 publications

(17 citation statements)

References 146 publications

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“…This finding is relevant considering that in recent studies it has been shown that the metabolic alterations present in MetS are associated with renal damage in the microstructure by various mechanisms, including OxS. In this sense, it has been reported that the administration of flavonoids of a natural origin has mitigated OxS, so we can suggest that the active substances present in S. edule are acting synergistically, and that they have a renal-protective effect of clinical importance and could be an alternative in the prevention of kidney damage [36,37,38].…”

Section: Discussionmentioning

confidence: 98%

Effect of Sechium edule var. nigrum spinosum (Chayote) on Oxidative Stress and Pro-Inflammatory Markers in Older Adults with Metabolic Syndrome: An Exploratory Study

et al. 2019

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Metabolic syndrome (MetS) is a risk factor for cognitive deterioration and frailty in older adults. In this regard it has been shown that oxidative stress (OxS) and chronic inflammation are involved in the pathophysiology of these alterations. Harmless antioxidant and anti-inflammatory therapeutic alternatives have been proposed, such as the consumption of Sechium edule (chayote), but the evidence is inconclusive. For this reason, an exploratory study of a single group chosen by convenience sampling, including 12 older adults, with an average age of 71 ± 6 years (10 women and 2 men) with a diagnosis of MetS according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III) criteria. This exploratory study aimed to determine the effect of the consumption of the dried fruit powder supplement of Sechium edule var. nigrum spinosum (500 mg, 3 times per day) for six weeks on the markers of OxS in elderly adults with MetS. All participants’ OxS markers were measured before and after treatment. There was a statistically significant decrease in the concentration of lipoperoxides (baseline, 0.289 ± 0.04 vs. post-treatment, 0.234 ± 0.06 μmol/L, p < 0.05), together with a significant increase in total antioxidant status (baseline, 0.97 ± 0.18 vs. post-treatment, 1.2 ± 0.12 mmol/L, p < 0.05). In this sense, the oxidative stress index showed a statistically significant decrease (baseline, 1.7 ± 0.78 vs. post-treatment, 0.75 ± 0.87, p < 0.05). A statistically significant decrease in the concentration of TNF-α after treatment was also found (baseline, 5.3 ± 1.4 vs. post-treatment, 3.5 ± 1.3, p < 0.05).Our findings suggest that the consumption of the dry fruit of Sechium edule has an antioxidant and anti-inflammatory effect in older adults with metabolic syndrome.

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Section: Discussionmentioning

confidence: 98%

Effect of Sechium edule var. nigrum spinosum (Chayote) on Oxidative Stress and Pro-Inflammatory Markers in Older Adults with Metabolic Syndrome: An Exploratory Study

et al. 2019

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“…It is well documented that MetS has become a key factor in the risk of developing chronic kidney disease. These effects can be associated with insulin resistance, hypertension, dyslipidemia, inflammation, and OxS [38]. One study suggested a protective effect of Sechium edule leaves against nephrotoxicity in animal models, showing a reduction in serum markers of renal damage such as urea, creatinine, and uric acid [39].…”

Section: Discussionmentioning

confidence: 99%

Effect of Sechium edule var. nigrum spinosum (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

et al. 2020

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Patients with metabolic syndrome (MetS) have a redox imbalance, due to a decay in antioxidant capacity. Oxidative stress (OxS) is considered an important modulator of telomere shortening and telomerase activity. One of the fruits that has been associated with an antioxidant effect is Sechium edule and although its properties are well established, there is only one exploratory study evaluating its effectiveness in patients with MetS. The present investigation is a much more robust and controlled study, including a placebo group. Hence, we determined the effect of consumption of the dried fruit powder (500 mg, three times per day) for three months. We measured effects on telomerase levels, antioxidant capacity, and markers for OxS. The study was performed in a sample of 75 older adults: placebo group (n = 30) and experimental group (n = 45) with the diagnosis of MetS according to the National Adult Treatment Panel of the National Cholesterol Program III (NCEP/ATP III) criteria. All markers were measured before and after three months of treatment. There was a statistically significant decrease in lipoperoxides and protein carbonylation with an increased superoxide dismutase (SOD), as well as sustained levels of telomerase in patients who consumed Sechium edule. Our findings suggest that consumption of this fruit has a hypoglycemic, hypotensive, and antioxidant effect, without altering telomerase levels, which could suggest better protection against telomere shortening.

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“…Kidney injury is associated with developing metabolic syndrome (MetS). The number of patients with MetS is increasing and has become a risk factor for the development of kidney injury, therefore, predicting the development of CKD patients [6,7]. It is estimated that the MetS affects at least a quarter of the adult population worldwide [8].…”

Section: Introductionmentioning

confidence: 99%

Plasma triglyceride levels and central obesity predict the development of kidney injury in Chinese community older adults

Cao

Sun²,

et al. 2019

Renal Failure

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Objective: Despite the achievement of blood glucose, blood pressure targets, the risk for kidney injury remains high among older adults. This observational retrospective study investigated whether high TG or high WC contribute to this high residual risk for kidney injury. Methods: A total of 843 elderly from Dongli Community, Tianjin, China, we selected 666 individuals with a baseline estimated glomerular filtration rate (eGFR) 60 mL/min/1.73 m 2 and negative microalbuminuria completing a 3-year follow-up. At baseline, subjects were grouped according to the levels of TG and WC. The primary outcome was the incidence of kidney injury, defined as low eGFR (eGFR <60 mL/min/1.73 m 2) or reduced eGFR (eGFR reduced >25%) or UACR 30 mg/g. Results: Overall, 6.01% developed low eGFR, 11.11% reduced eGFR, 25.98% UACR 30 mg/g, and 3.45% low eGFR and UACR 30mg/g after 3-year follow-up. TG 1.7 mmol/L increased the risk of eGFR <60 mL/min/1.73 m 2 by 1.44-fold, of UACR 30 mg/g by 32%, and of developing both abnormality by 1.41-fold in model 1; further adjustment for potential confounders factors, the association is slightly weakened in model 2 and 3; WC (90 cm in men and 85 cm in women) were associated with a 1.68-fold higher risk of eGFR <60 mL/min/1.73 m 2 and a 1.43fold risk of UACR 30 mg/g and a 1.89-fold risk of developing both abnormality in model 1. Further adjustment for potential confounders factors, the association is slightly weakened in model 2 and 3. Conclusions: In a population of Chinese community-dwelling older adults, high TG and central obesity were risk factors for the development of kidney injury over 3 years.

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Renal damage in the metabolic syndrome (MetSx): Disorders implicated

Cited by 24 publications

References 146 publications

Effect of Sechium edule var. nigrum spinosum (Chayote) on Oxidative Stress and Pro-Inflammatory Markers in Older Adults with Metabolic Syndrome: An Exploratory Study

Effect of Sechium edule var. nigrum spinosum (Chayote) on Oxidative Stress and Pro-Inflammatory Markers in Older Adults with Metabolic Syndrome: An Exploratory Study

Effect of Sechium edule var. nigrum spinosum (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

Plasma triglyceride levels and central obesity predict the development of kidney injury in Chinese community older adults

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