Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy

Huang, Jionghua; Huang, He; Pan, Wei; Ou, Dejin; Dai, Wenjun; Lin, Yani; Wu, Jinlei; Xie, Wenjie; Chen, Ximing

doi:10.3892/mmr.2017.6790

Cited by 1 publication

(2 citation statements)

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“…The different effects of RDN on autophagy in various disease models have been previously studied. Huang et al have reported that RDN plays a cardioprotective role via reduction of autophagic responses in spontaneously hypertensive rats, while Liu et al have shown that RDN ameliorates cardiac dysfunction by enhancing autophagy in rats with diabetes. In the present study, we found that RDN indeed regulated autophagic flux after pressure overload.…”

Section: Discussionmentioning

confidence: 99%

“…Our group also has found that RDN promotes cardiac angiogenesis in a rat model of transverse aortic constriction (TAC)‐induced cardiac hypertrophy . A more recent study performed on spontaneously hypertensive rats revealed a potential association between cardiac protection of RDN and autophagy . However, whether and how RDN affects autophagic activity in cardiac remodelling and heart failure induced by TAC is not known.…”

Section: Introductionmentioning

confidence: 98%

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Renal denervation attenuates pressure overload‐induced cardiac remodelling in rats with biphasic regulation of autophagy

et al. 2019

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Aim This study aimed to investigate effects of renal denervation (RDN) on pressure overload‐induced cardiac remodelling in rats and the related mechanisms. Methods Adult male Sprague‐Dawley rats underwent transverse aortic constriction (TAC) to generate cardiac remodelling. RDN was performed 1 week after TAC. The animals were divided into four groups: control group, TAC group, TAC+RDN group and control+RDN group. Rats in all groups were studied at 3 and 10 weeks after TAC respectively. Echocardiography and histology were used to evaluate cardiac function and pathological changes. TUNEL staining and western blotting were used to assess apoptosis. Western blotting and transmission electron microscopy (TEM) were used to evaluate autophagy. Results Three weeks after TAC, the TAC rats exhibited cardiac hypertrophy with normal cardiac function and no myocardial interstitial fibrosis or apoptosis, accompanied by a lower LC3 II level and fewer autophagic vacuoles in the left ventricles, both in the presence and absence of chloroquine (CQ), indicating suppressed autophagy at this stage. RDN ameliorated these pathological changes and attenuated the decrease in autophagy. Ten weeks after TAC, the TAC rats had decreased cardiac function, obvious cardiac interstitial fibrosis and apoptosis, with increased autophagy. RDN prevented these pathological changes, coincident with attenuation of increased autophagy. Conclusion Autophagy was suppressed at the early stage but activated at the late stage of TAC‐induced cardiac remodelling. RDN attenuated the pathological changes of TAC rats, accompanied by attenuation of the changes in autophagy. Thus, RDN ameliorated TAC‐induced cardiac remodelling partially associated with biphasic modulation of autophagy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%