Renal denervation may attenuate the severity of MRI-signs of vascular wall damage in diabetic patients with resistant hypertension due to the anti-inflammatory effect

Фальковская, А. Ю.; Mordovin, V.; Рюмшина, Н. И.; Пекарский, С. Е.; Ripp, T.; Манукян, М. А.; Зюбанова, И. В.; Lichikaki, V.; Sitkova, E.; Суслова, Т. Е.; Гусакова, А. М.; Kurlov, I. O.; Baev, A.

doi:10.18705/1607-419x-2020-26-5-552-563

Cited by 7 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Нами впервые установлено, что снижение ММЛЖ ассоциировалось с уменьшением содержания в крови уровней ММП-9 и ММП-2, что подтверждает вовлеченность коллагенообразования в процессы ГЛЖ. А поскольку подавление коллагенообразования после РДН происходит не только в миокарде, но и в сосудистой стенке [11], улучшение ее механических характеристик может положительно влиять на левожелудочково-артериальное взаимодействие, уменьшать пульсатильную нагрузку на ЛЖ и дополнительно способствовать регрессу ГЛЖ.…”

Section: Discussionunclassified

Regression of left ventricular hypertrophy in patients with resistant hypertension after renal denervation: the role of hemodynamic and antifibrotic effects

Solonskaya,

Mochula,

Mordovin

et al. 2024

Russ J Cardiol

Self Cite

View full text Add to dashboard Cite

Aim. To study the features of regression of left ventricular hypertrophy and magnetic resonance changes of cardiac fibrosis in patients with resistant hypertension (RH) 1 year after renal denervation (RDN) in relation to changes in blood pressure (BP), the level of high-sensitivity C-reactive protein (hsCRP), matrix metalloproteinases 2, 9 (MMP-2, MMP-9), tissue inhibitor of metalloproteinase type 1 (TIMP-1).Material and methods. The study included 42 patients with true RH. The mean age of the patients was 59 (51; 62) years, while half were men. All patients took 3 or more antihypertensive drugs. At baseline and after 12 months, creatinine, hsCRP, MMP-2, MMP-9, TIMP-1 were determined, as well as 24-hour blood pressure monitoring, assessment of left ventricular mass (LVM) and contrast agent accumulation according to cardiac MRI. RDN was performed using Symplicity Fleх (n=18) and Symplicity Spyral (n=24) catheters in accordance with the manufacturer's instructions.Results. A year after RDN, a significant antihypertensive effect and a decrease in heart rate were noted. Sixteen patients (38,1%) reached the target office BP level. After 1 year, a significant decrease in the levels of hsCRP from 2,05 (1,04; 3,28) to 1,64 (0,96; 2,25) mg/l (p=0,045) and MMP-2 from 278,2 (240,9; 353,4) to 265,2 (221,2; 293,2) ng/ml (p=0,018) was detected. There was a trend towards an increase in TIMP-1 and a decrease in MMP-9. According to MRI 1 year after RDN, there was a tendency to increase the contrast agent volume, and there was a pronounced LVM decrease from 228 (180; 295,2) to 204 (169,8; 277) g (p=0,029). Correlation analysis revealed a direct connection between a decrease in LVM and a decrease in SBP and DBP levels, MMP-2 and MMP-9 levels. There was a relationship between a decrease in the contrast agent volume and an increase in TIMP-1 level (r=-0,64; p=0,04).Conclusion. A year after RDN, patients with RH show regression of left ventricular hypertrophy with a pronounced antihypertensive effect and a decrease in collagen production, which could also be significant for suppressing the myocardial fibrosis.

show abstract

Section: Discussionunclassified

Regression of left ventricular hypertrophy in patients with resistant hypertension after renal denervation: the role of hemodynamic and antifibrotic effects

Solonskaya,

Mochula,

Mordovin

et al. 2024

Russ J Cardiol

Self Cite

View full text Add to dashboard Cite

show abstract

Immunoinflammatory Processes in the Pathogenesis of Atherosclerosis

Mordovin,

Zyubanova,

Manukyan

et al. 2023

Kompleks. probl. serdečno-sosud. zabol.

View full text Add to dashboard Cite

HighlightsThe article describes the main pathogenetic aspects of atherogenesis and focuses on the role of low-intensity inflammation in this process. Moreover, the article presents data on the possibilities of predicting cardiovascular outcomes in patients using a number of pro-inflammatory markers, and on the effectiveness of anti-inflammatory therapy in this cohort of patients. AbstractChronic low-intensity inflammation is currently considered one of the most significant risk factors for cardiovascular disease. The initiation and progression of atherosclerosis are associated with an inflammatory response to endothelial damage, accompanied by an increase in number of pro-inflammatory markers blood circulation. The atherogenic effect of the main risk factors for atherosclerosis, such as hypertension, smoking, increased dietary fat intake, physical inactivity and obesity, as well as psychological and emotional factors and sleep disturbance, is mostly carried out through these mechanisms. In addition, proinflammatory cytokines blood levels increase is associated with sympathetic tone level increase under these risk factors influence.The article describes the relevant atherogenesis mechanisms and the results of large clinical trials studying the relationship between inflammatory activity, assessed by the levels of various pro-inflammatory markers, and the risk of cardiovascular complications. Data regarding the use of anti-inflammatory drugs such as canakinumab, anakinra, tocilizumab, colchicine to treat patients with coronary artery disease are given. The efficacy of nano-immunotherapy, when powerful anti-inflammatory agents are target delivered to atherosclerotic plaques using nanoparticles, is considered, as well as the anti-inflammatory effect of renal denervation due to the sympatholytic activity of this procedure.

show abstract

Hypertension and diabetes mellitus: Clinical and pathogenetic features and state-of-the-art high-tech treatment capabilities (Review)

Falkovskaya

Zyubanova

Manukyan

et al. 2021

SJCEM

View full text Add to dashboard Cite

This paper discusses the clinical and pathogenetic aspects of hypertension comorbid with type 2 diabetes mellitus. The role of sympathetic hyperactivation in the mechanisms of this comorbidity and the damage to target organ are reviewed. Authors analyze the capabilities of endovascular renal artery denervation and discuss the mechanisms of therapeutic effect of this procedure. The article is intended for cardiologists, therapists, endocrinologists, and endovascular surgeons.

show abstract

Renal denervation may attenuate the severity of MRI-signs of vascular wall damage in diabetic patients with resistant hypertension due to the anti-inflammatory effect

Cited by 7 publications

References 27 publications

Regression of left ventricular hypertrophy in patients with resistant hypertension after renal denervation: the role of hemodynamic and antifibrotic effects

Regression of left ventricular hypertrophy in patients with resistant hypertension after renal denervation: the role of hemodynamic and antifibrotic effects

Immunoinflammatory Processes in the Pathogenesis of Atherosclerosis

Hypertension and diabetes mellitus: Clinical and pathogenetic features and state-of-the-art high-tech treatment capabilities (Review)

Contact Info

Product

Resources

About