Renal development in the fetus and premature infant

Rosenblum, Stacy D.; Pal, Abhijeet; Reidy, Kimberly

doi:10.1016/j.siny.2017.01.001

Cited by 89 publications

(45 citation statements)

References 160 publications

(160 reference statements)

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“…57 Fetal kidney development begins in the first trimester, with an exponential increase in nephrons occurring between 18 and 32 weeks of gestation. 58 Any policy that improves glycemic control during this period may potentially reduce genitourinary abnormalities. 4 Pre-gestational diabetes can remain undiagnosed, and screening among at-risk women early in pregnancy provides an opportunity to diagnose and improve glycemic condition in utero during development, leading to improved outcomes.…”

Section: Clinical Researchmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of Diabetes During Pregnancy and Congenital Genitourinary Abnormalities

Parimi

Nitsch

2020

Kidney International Reports

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Introduction: This study aimed to assess available epidemiological evidence of the relationship between diabetes during pregnancy and congenital abnormalities of the kidney and the urinary tract (CAKUT). Methods: POPLINE, MEDLINE, EMBASE, Global Health, CINAHL, and Cochrane Library were searched to retrieve 6962 articles of which 15 case-control and 11 cohort studies met the inclusion criteria. Randomeffects meta-analysis was performed to estimate the association between CAKUT and diabetes during pregnancy. Results: Offspring born to mothers with any form of diabetes in pregnancy had a 50% increased risk of CAKUT compared with offspring of mothers without diabetes (relative risk [RR], 1.51; 95% confidence interval [CI], 1.36-1.67). Compared with offspring with nondiabetic mothers, offspring of mothers with preexisting diabetes had an almost 2-fold rate of CAKUT (RR, 1.97; 95% CI, 1.52-2.54). Offspring of mothers with gestational diabetes had a 39% increased risk of CAKUT (RR, 1.39; 95% CI, 1.26-1.55) compared with offspring of mothers with no diabetes. The subset of studies that adjusted for body mass index (BMI) before pregnancy showed similar associations. Population attributable risks for gestational diabetes were estimated to be 3.7% of cases of CAKUT in the United States, 4% of CAKUT cases in the United Kingdom, with up to 14.4% CAKUT cases in the South Asian population in the United Kingdom. Conclusion: This study suggests that 2.0% to 3.7% of cases of CAKUT in the United States, and up to 14% of CAKUT in some populations could be eliminated if gestational diabetes was prevented or eliminated.

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Section: Clinical Researchmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of Diabetes During Pregnancy and Congenital Genitourinary Abnormalities

Parimi

Nitsch

2020

Kidney International Reports

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“…The kidney is an important organ in the urinary system. Although much endeavor has been made for the fetal kidney (Hochane et al, 2019;Wang et al, 2018;Young et al, 2018), the 19-20 weeks post-gestation, a key period when glomerular filtration started to significantly contribute to amniotic fluid (Rosenblum et al, 2017), was rarely covered. In the analysis of the data from the high-precision library preparation method, we were able to find 27 cell types in the kidney ( Figure S4A).…”

Section: Construction Of the Single-cell Transcriptome Landscape Formentioning

confidence: 99%

Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation Fetus

Tian

Zhou

et al. 2020

Preprint

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Highlights• Genomic Architecture of Cells in Tissues (GeACT) data for human mid-gestation fetus • Determining correlated gene modules (CGMs) in different cell types by MALBAC-DT • Measuring chromatin open regions in single cells with high detectability by METATAC • Integrating transcriptomics and chromatin accessibility to reveal key TFs for a CGM Summary By circumventing cellular heterogeneity, single cell omics have now been widely utilized for cell typing in human tissues, culminating with the undertaking of human cell atlas aimed at characterizing all human cell types. However, more important are the probing of gene regulatory networks, underlying chromatin architecture and critical transcription factors for each cell type. Here we report the Genomic Architecture of Cells in Tissues (GeACT), a comprehensive genomic data base that collectively address the above needs with the goal of understanding the functional genome in action. GeACT was made possible by our novel single-cell RNA-seq (MALBAC-DT) and ATAC-seq(METATAC) methods of high detectability and precision. We exemplified GeACT by first studying representative organs in human mid-gestation fetus. In particular, correlated gene modules (CGMs) are observed and found to be cell-type-dependent.We linked gene expression profiles to the underlying chromatin states, and found the key transcription factors for representative CGMs.

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“…Chronic kidney disease (CKD) was evident from childhood: at 9 years of age his serum creatinine was 1.04 mg/dL (92 μmol/L). The patient was an early-preterm baby (born at 30 weeks) with very low birth weight (910 g), both elements associated with an increased risk of developing several metabolic diseases including CKD [ 24 ].…”

Section: Case Presentationmentioning

confidence: 99%

Full normalization of severe hypertension after parathryoidectomy – a case report and systematic review

et al. 2018

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BackgroundAlthough the relationship between hyperparathyroidism and hypertension has been described for decades, the role of hyperparathyroidism in hypertension in dialysis is still unclear. Following the case of a severely hypertensive dialysis patient, in which parathyroidectomy (PTX) corrected the metabolic imbalance and normalized blood pressure (BP), we tried to contextualize our observation with a systematic review of the recent literature on the effect of PTX on BP.Case presentationA dialysis patient, aged 19 years at the time of this report, with chronic kidney disease (CKD) from childhood; he was an early-preterm baby with very low birth weight (910 g), and is affected by a so-far unidentified familial nephropathy. He started dialysis in emergency at the age of 17. Except for low-dose Bisoprolol, he refused all chronic medication; hypertension (165–200/90–130 mmHg) did not respond to attainment of dry weight (Kt/V > 1.7; BNP 70–200 pg/ml pre-dialysis). He underwent subtotal PTX 1 year after dialysis start; after PTX, his blood pressure stabilized in the 100–140/50–80 range, and is normal without treatment 5 months later.ConclusionOur patient has some peculiar features: he is young, has a non-immunologic disease, poor compliance to drug therapy, excellent dialysis efficiency. His lack of compliance allows observing the effect of PTX on BP without pharmacologic interference.The prompt, complete and long-lasting BP normalization led us to systematic review the current literature (Pubmed, Embase, Cochrane Collaboration 2000–2016) retrieving 8 case series (194 cases), and one case report (3 patients).The meta-analysis showed a significant, albeit moderate, improvement in BP after PTX (difference: systolic BP -8.49 (CI 2.21–14.58) mmHg; diastolic BP -4.14 (CI 1.45–6.84) mmHg); analysis is not fully conclusive due to lack of information on anti-hypertensive agents. The 3 cases reported displayed a sharp reduction in BP after PTX.In summary, PTX may have a positive influence on BP control, and may result in complete correction or even hypotension in some patients. The potential clinical relevance of this relationship warrants prospective large-scale studies.

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Renal development in the fetus and premature infant

Cited by 89 publications

References 160 publications

A Systematic Review and Meta-Analysis of Diabetes During Pregnancy and Congenital Genitourinary Abnormalities

A Systematic Review and Meta-Analysis of Diabetes During Pregnancy and Congenital Genitourinary Abnormalities

Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation Fetus

Full normalization of severe hypertension after parathryoidectomy – a case report and systematic review

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