Renal Disease and Pregnancy

Hnat, Michael; Sibai, Baha M.

doi:10.3843/glowm.10157

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Plasma kreatinine levels exceeding 0.80 (0.7-1.2) mg/dL are accepted as the sign of renal dysfunction. Proteinuria is accepted as nephrotic when 24-hour urinary protein levels exceed 3.5 grams [11]. All patients were under special antenatal care and perinatal surveillance program (genetic counselling, prenatal screening/diagnosis, ultrasonographic evaluation, Doppler velocimetry, nonstress test, as well as related maternal laboratory tests) and examined bi-weekly (more frequent when necessary) after 24 th gestational week until delivery.…”

Section: Methodsmentioning

confidence: 99%

“…Normal pregnancy is associated with increased renal plasma flow and GFR, together with decreased serum creatinine and hyperfiltration of amino acids, proteins, and water soluble vitamins [11]. All these shifts together with hemostatic and hormonal imbalances may aggravate NS occurrence in patients with PGDs but does not change the natural course of the disease [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Primary glomerular diseases and pregnancy

Beksaç¹,

Ertürk²,

Beksaç³

et al. 2018

Clin. Exp. Obstet. Gynecol.

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Backround: Primary glomerular diseases (PGD) may represent wide spectrum of clinical presentations and pathological findings depending on the histopathological type and the severity/stage of the disease. The severity of PGD-related nephrotic syndrome (NS) predicts pregnancy outcome. The aim of the study to assess whether PGD has any effect on pregnancy and fetal outcome, as well as the effect of pregnancy on PGD. Materials and Methods: Retrospectively, ten pregnant women (11 pregnancies) with PGDs at Hacettepe University were investigated in terms of their pregnancy outcomes. The histopathological diagnosis was focal segmental glomerulosclerosis (FSGS), FSGS superimposed on immunglobulin A ( IgA) nephropathy, membrano-proliferative glomerulonephritis (MPGN), and minimal change disease (MCD). Results: Nearly all pregnancies were complicated by nephrotic "signs and symptoms" and NS to a certain extend (mild-moderate to severe forms) and all cases were delivered by cesarean section. Eight cases (72.7 %) were complicated with IUGR, fetal distress and preterm delivery. Conclusion: In this case series, the authors have demonstrated that PGD has an adverse impact on perinatal outcome.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary glomerular diseases and pregnancy

Beksaç¹,

Ertürk²,

Beksaç³

et al. 2018

Clin. Exp. Obstet. Gynecol.

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“…Tests of renal functions in pregnancy must be interpreted in relation to the changes in plasma volume, glomerular filtration and tubular reabsorption that normally occur with advancing gestation, blood urea nitrogen and serum creatinine levels are crude indices of renal function, the blood urea nitrogen normally decrease from non pregnant levels of 12 mg/dl to 9 mg/dl and plasma creatinine levels decrease from non pregnant mean value of 0.07 mg/dl to 0.05 mg/dl, if serum creatinine exceed the 0.08 mg/dl or blood urea nitrogen exceed the 14 mg/dl at any stages of pregnancy, renal dysfunction should be suspected [10].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of renal functions tests among Sudanese healthy pregnant women attending antenatal care (ANC) at The National Ribat University Hospital in Khartoum State in 2019

2021

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Pregnancy involves remarkable physiological changes and the functional impact of pregnancy on the kidney physiology is widespread involving practically all aspects of kidney functions. The aim of this study was to evaluate the renal functions in Sudanese healthy pregnant ladies during different trimesters. A cross sectional study was carried out during July to October 2019 on Sudanese healthy pregnant ladies attending antenatal care at the National Ribat University Hospital in Khartoum State. The study covered 60 healthy pregnant ladies (20 for each trimester). The purpose of the study was explained to all participants and they were assessed after taking their consent. Blood pressure (BP) and body mass index (BMI) were measured by standard techniques. A sample of five ml venous blood was taken in a suitable blood container for measurement of urea and creatinine using a fully automated Mindray BS-300 Chemistry Analyzer (Mindray Bio-Medical Electronics Co., Ltd., Shenzhen, China). The data was analyzed using SPSS version 25 (IBM SPSS Inc.,Chicago, IL, USA), t-test was used to compare the statistical significant (p value ≤ 0.05 was considered statistical significant). The mean age of participants was 26.6±5.3 years with the range of 18-37 years. The mean BMI was 25.7±3.6 with the range of 18-31. The mean urea in the first, second and third trimester was 13.4, 13.9 and 13.2 mg/dl respectively with no statistically significant variation. The mean creatinine in the first, second and third trimester was 0.6, 0.6 and 0.5 mg/dl respectively with no statistically significant variation. To conclude, there was no significant variation of serum urea and creatinine during three trimesters of pregnancy in healthy pregnant women.

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A Critical Review of Recent Randomized Controlled Clinical Trials in the Treatment of Asymptomatic Bacteriuria of Pregnancy

Stothers

1995

Journal SOGC

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Renal Disease and Pregnancy

Cited by 6 publications

References 23 publications

Primary glomerular diseases and pregnancy

Primary glomerular diseases and pregnancy

Evaluation of renal functions tests among Sudanese healthy pregnant women attending antenatal care (ANC) at The National Ribat University Hospital in Khartoum State in 2019

A Critical Review of Recent Randomized Controlled Clinical Trials in the Treatment of Asymptomatic Bacteriuria of Pregnancy

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