Renal Disease Following Prophylactic Inoculation

Abstract

An acute immune disease is described in a 53-year-old man following preventive TAB inoculation. Very florid involvement of the renal vascular tree was associated with renal failure. Involvement of the vessels of the pulmonary tree and spleen also occurred. A retrospective review of 420 patients with glomerulonephritis seen during the last 10 years disclosed eight patients with histories strongly suggestive of renal involvement related in time to preventive inoculation. The possibility that occult renal involvement related to preventive inoculation may cause ‘latent’ glomerulonephritis in some patients is raised.

Vaccination and Autoimmunity—‘vaccinosis’: A Dangerous Liaison?

“…A number of patients were described [78] who developed systemic symptoms (gastrointestinal, dermatological, respiratory) with involvement of the kidneys and evidence of glomerulonephritis (GN). On renal biopsy immunofluorescence studies were positivemainly with anti-C3 and anti-IgG conjugates.…”

“…On renal biopsy immunofluorescence studies were positivemainly with anti-C3 and anti-IgG conjugates. The disease in these patients developed after receiving a variety of vaccines [79][80][81] (Table 3) and their outcomes differed significantly: two patients died of renal failure, five patients recovered completely, and one patient remained with persistent glomerular changes [78].…”

“…The immunization may also imply the appearance of, or increase in immune complexes [51] which can in turn cause the vasculitis noted in several cases, or the exacerbation of existing autoimmune symptoms (such as worsening of renal function [78]). …”

Oral immunization using live attenuated Salmonella spp. as carriers of foreign antigens

“…In addition, parenteral administration of large numbers of killed organisms frequently results in adverse reactions such as local discomfort, redness, swelling, fever, headache, myalgia, and general malaise (1,21,73,145). More severe systemic manifestations such as anaphylactic shock, acute renal disease, appendicitis, and erythema nodosum, although rare, have also been observed (13,75,80,101). Oral killed vaccines against typhoid fever do not generally produce side effects but have been shown to induce only low levels of circulating and secretory antibodies and insignificant levels of protection against challenge (59).…”

Oral immunization using live attenuated Salmonella spp. as carriers of foreign antigens.

“…In addition, parenteral administration of large numbers of killed organisms frequently results in adverse reactions such as local discomfort, redness, swelling, fever, headache, myalgia, and general malaise (1,21,73,145). More severe systemic manifestations such as anaphylactic shock, acute renal disease, appendicitis, and erythema nodosum, although rare, have also been observed (13, 75,80,101). Oral killed vaccines against typhoid fever do not generally produce side effects but have been shown to induce only low levels of circulating and secretory antibodies and insignificant levels of protection against challenge (59).…”