Renal Disease in Multiple Myeloma: Current Perspectives

Iggo, Neil; Parsons, V.

doi:10.1159/000186145

Cited by 16 publications

(2 citation statements)

References 14 publications

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“…CAPD and haemodialysis appear equally effective in terms of patient outcome and choice should probably be decided as for non-myeloma patients (Iggo & Parsons 1990). This is despite, on the one hand, the theoretical advantages of CAPD in removing immunoglobulins (Iggo et a!.…”

Section: Discussionmentioning

confidence: 99%

Intensive treatment of renal failure in patients with myeloma

Innes

Cuthbert

Russell

et al. 2008

Clinical &Amp; Laboratory Haematology

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Summary. We have reviewed our experience in the management of myeloma patients who present with features of severe renal impairment, to examine the role of intensive treatment of the renal failure, and to assess the role of renal biopsy. Between March 1983 and August 1991, 16 patients, who were subsequently diagnosed as having myeloma, presented to the Department of Renal Medicine for investigation of renal failure; nine with symptoms of uraemia and seven with pneumonia, bone pain, emphysema, or ischaemic heart disease. Renal biopsy was performed on 14 patients. Eleven patients had myeloma cast nephropathy, two of whom had concurrent hypertensive nephropathy, two patients had light chain deposition disease, and one patient had interstitial nephritis. Renal function improved in six patients with aggressive rehydration, but three of them subsequently required dialysis. In all 11 patients required dialysis, two short‐term and nine long‐term. Seven patients were given conventional melphalan and prednisolone and nine patients received VAMP as induction cytotoxic chemotherapy. Five of the VAMP sub‐group received interferon α2b as maintenance therapy. The median renal survival was five months (range 0–36 months) and median overall survival was 20 months (range 1–54 months). We conclude that intensive treatment, including dialysis, in myeloma patients with renal failure may result in survival durations approaching those of unselected myeloma patients, and a significant proportion will enjoy a reasonable quality of life.

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Section: Discussionmentioning

confidence: 99%

Intensive treatment of renal failure in patients with myeloma

Innes

Cuthbert

Russell

et al. 2008

Clinical &Amp; Laboratory Haematology

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“…Renal involvement is a frequent complication of multiple myeloma and has been widely regarded as one of the major causes of death [1]. Eight major morphologically well-defined types of involvement may develop: (1) Bence Jones cast nephropathy, (2) light chain protein deposit disease, (3) amyloidosis, (4) Waldenstrom's macroglobu linémie glomerulonephropathy, (5) type I and 11 cryoglobu linémie glomerulonephropathy, (6) neoplastic infiltration, (7) nephrocalcinosis and (8) Fanconi's syndrome with crys talline inclusion bodies in the tubular epithelium [2][3][4][5][6][7], The first three were the most characteristic types of involvement in multiple myeloma [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Unusual Findings in a Myeloma kidney: A Light- and Electron-Microscopic Study

Lam

Chan²

1993

Nephron

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A case of IgD myeloma together with the existence of myelofibrosis is presented. More interesting is the concurrent presence of cast nephropathy, light chain deposition and amyloidosis in the kidney. Peculiar light-microscopic, immunohistochemical, immunofluorescence and ultrastructural findings were also noted. The possible mechanisms and implications for such findings were discussed. This case was analyzed together with a review of local pictures of renal involvement in multiple myeloma.

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Transplantation in Inherited, Systemic, and Metabolic Diseases

Lederer

1998

Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS

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Renal Disease in Multiple Myeloma: Current Perspectives

Cited by 16 publications

References 14 publications

Intensive treatment of renal failure in patients with myeloma

Intensive treatment of renal failure in patients with myeloma

Unusual Findings in a Myeloma kidney: A Light- and Electron-Microscopic Study

Transplantation in Inherited, Systemic, and Metabolic Diseases

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