Renal disease in rheumatoid arthritis.

Dieppe, Paul; Doyle, D V; Burry, H. C.; Tucker, Susan

doi:10.1136/bmj.1.6010.611

Cited by 37 publications

(7 citation statements)

References 12 publications

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“…Our study confirms the presence of pathological albuminuria in many RA patients without a history of renal dysfunction, hypertension, or diabetes mellitus. Our findings are consistent with earlier reports concerning subclinical renal dysfunction in RA [16,17].…”

Section: Discussionsupporting

confidence: 94%

Microalbuminuria in Rheumatoid Arthritis Patients: Clinical and Biochemical Correlates

Saif¹

2015

Rheumatology (Sunnyvale)

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Background: Microalbuminuria is associated with increased risk for renal and cardiovascular mortality and morbidity in diabetes mellitus, hypertension and patients with acute myocardial infarction but the significance of microalbuminuria in rheumatoid arthritis and its correlation with clinical and biochemical parameters of disease activity is not well studied. The present study is therefore aimed to determine the presence of microalbuminuria in rheumatoid arthritis patients and to correlate it with indicators of disease activity. Materials and methods: Hundred confirmed cases of rheumatoid arthritis (2010 ACREULAR criteria) were taken. Those suffering from hypertension, diabetes mellitus and renal disease were excluded. Microalbumin was assessed by immunoturbidimetric method on Delta nephelometer. Disease activity was assessed by CRP and ESR. Results: Out of 100 RA, 30 (30%) were males and 70 (70%) females with a mean age of patients 43(17 ± 11.16 years). 28(28%) cases had microalbuminuria. Duration of morning stiffness was significantly longer in patients with microalbuminuria. Out of 28 patients positive for microalbuminuria, 12 patients had morning stiffness lasting >60 min. Mean no. of joints involved was 18.96 ± 6.01 in microalbuminuria positive group (P<0.001).14 of the 28 patients with microalbuminuria had evidence of erosions on xray (P value of <0.001). Mean ESR in microalbuminuria positive patients was 87.93 ± 26.02 mm in 1st hour (P value of <0.001). Mean CRP in microalbuminuria positive patients was 48.78 ± 16.06 mg/l (P value of <0.001). Mean value of RA in microalbuminuria positive patients was 211.89 ± 97.39 IU/dl (P value of <0.001).An independent association was found between levels of RA Factor (β=0.540, P <0.001) and level of microalbuminuria. Conclusion: RA patients having microalbuminuria have significant clinical and biochemical correlation with severe disease activity.Immunological methods for detecting microalbuminuria should routinely be used in all rheumatoid arthritis patients to detect renal involvement in an incipient stage so as to minimize disease morbidity.

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Section: Discussionsupporting

confidence: 94%

Microalbuminuria in Rheumatoid Arthritis Patients: Clinical and Biochemical Correlates

Saif¹

2015

Rheumatology (Sunnyvale)

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“…This is consistent with the earlier reports regarding subclinical renal dysfunction in RA. 18 The reversible subclinical stage of renal disease may stay unnoticed for a long duration, and it's necessary to detect it at the earliest. The usual measures used for measuring kidney function like urine total protein assays, urine dipstick testing, urine cytology and serum creatinine may not identify mild to moderate damages to the kidneys.…”

Section: Discussionmentioning

confidence: 99%

A Correlative Study of Micro Albuminuria in Rheumatoid Arthritis and Its Association With Disease Activity in Thanjavur Medical College, Southern Region

Ganesan¹,

V.P²,

Paranthakan³

2017

jebmh

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BACKGROUND This study was done to assess the subclinical renal involvement in Rheumatoid Arthritis (RA). To study (1) The prevalence of micro albuminuria in patients having rheumatoid arthritis. (2) The relationship between micro albuminuria and disease activity in rheumatoid arthritis as assessed by DAS28, ESR, CRP, RA factor, disease duration and constitutional symptoms. MATERIALS AND METHODS Descriptive type of cross-sectional study involving 60 patients attending Thanjavur Medical College, Thanjavur, and Rheumatology outpatient department, Thanjavur Medical College, Thanjavur diagnosed with RA by modified ACR criteria (1987). All the patients were tested for micro albuminuria by immunoassay method. RESULTS The mean age at diagnosis was 44.55 years (SD 13.767), females diagnosed at an earlier age than males (43.767 years (SD-14.128) vs. 46.529 years (SD-13.005)). 71.7% were females and 28.3% were males. MA was found in 19 patients (31.7%), of them, 16 patients had morning stiffness lasting for more than one hour, 18 patients had constitutional symptoms, and 10 patients were on treatment with NSAIDs or DMARDs. The mean duration of symptoms was 24.68 ± 12.06 months in MA positive group when compared with MA negative group with a mean value of 14.732 ± 8.093 (p-0.0004). The mean number of swollen joints in MA positive group was 15.89 ± 5.64 as compared to MA negative Group with a mean of 11.76 ± 6.31 (p-0.018). The mean number of tender joints involved in MA positive group was 14.32 ± 6.64 as against 9.76 ± 6.25 in MA negative group (p-0.0125).

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“…The disease affects 0.5–1% of the population at any age (mainly at the age of 50 years) with a female to male ratio of 2:1 (van der Woude & van der Helm‐van Mil, ). RA may also be accompanied by a variety of diseases, such as cardiovascular and cerebrovascular disease (Wolfe, Freundlich, & Straus, ), lung disease (Nannini, Ryu, & Matteson, ), and renal disease (Dieppe, Doyle, Burry, & Tucker, ). The pathogenesis of RA is inadequately understood.…”

Section: Introductionmentioning

confidence: 99%

Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

Zhang

2019

Phytotherapy Research

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Rheumatoid arthritis (RA) is a systemic disease characterized by autoimmunity, joint inflammation, and cartilage destruction, which affects 0.5–1% of the population. Many compounds from herbal medicines show the potentials to treat RA. On this basis, the compounds with good pharmacokinetic behaviors and drug‐likeness properties will be further studied and developed. Therefore, the herbal compounds with anti‐RA activities were reviewed in this paper, and the cheminformatics tools were used to predict their drug‐likeness properties and pharmacokinetic parameters. A total of 90 herbal compounds were analyzed, which were reported to be effective on RA models through anti‐inflammation, chondroprotection, immunoregulation, antiangiogenesis, and antioxidation. Most of the herbal compounds have good drug‐likeness properties. Most of the compounds can be an alternative and valuable source for anti‐RA drug discovery.

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Renal disease in rheumatoid arthritis.

Cited by 37 publications

References 12 publications

Microalbuminuria in Rheumatoid Arthritis Patients: Clinical and Biochemical Correlates

Microalbuminuria in Rheumatoid Arthritis Patients: Clinical and Biochemical Correlates

A Correlative Study of Micro Albuminuria in Rheumatoid Arthritis and Its Association With Disease Activity in Thanjavur Medical College, Southern Region

Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

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