Renal Disease in the Pigtailed Macaque (Macaca nemestrina)

Abstract

Spontaneous renal disease in the pigtailed macaque was evaluated in a prospective study of 20 apparently healthy monkeys that were killed and a retrospective study of 674 monkeys that died of spontaneous disease. Many apparently normal pigtailed macaques have a mesangioproliferative glomerulonephritis of slight to moderate severity. Deposition of immunoglobulin, particularly IgM, was common in renal glomeruli and did not seem to correlate with renal disease. Glomerulonephritis was found in 14% of the adult monkeys that died of spontaneous disease; in 4.2% it was severe enough to have caused renal failure. Tubular nephrosis was the most common renal lesion (22.6% of adults) and was usually a nephrotoxicity resulting from treatment of diarrhea with nephrotoxic antibiotics. Other lesions found were incidental or were secondary to disease processes in other organs. Pigtailed macaques that have been in our colony at least six months have a higher incidence of renal disease than is reported elsewhere in Old World monkeys.

Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes

“…42, No. 4, 2014 IMMUNE COMPLEXES IN MONKEYS AND OTHER SPECIES randomly selected adults; 20 were aged 2 to 3 years, 12 were aged 7 to 8 years IgM deposits in mesagium or along glomerular basement membrane in 72% IgG, C1q, C4, and C3 granular deposits in 30% TEM-dense granular deposits along glomerular basement membrane and in subepithelial and mesangial locations Greatest increases in IgM deposits were in animals with decreased serum C3, igM, and IgA Persistent, nonprogressive disease over 3 to 11 months; no defined relationship to age No associated renal insufficiency with normal serum BUN, creatinine Poskitt et al (1974) Pigtailed macaques (Macaca nemestrina) " mesangial cells/matrix w/thickening of capillary walls IgM deposits in glomeruli common 14% of adults with spotaneous disease deaths had ''asymptomatic'' mesangioproliferative glomerular disease No clear relationship between IgM and mesangioproliferative disease Giddens et al (1981) Antigen-IgM ICs might contribute to pathogenesis of severe mesangioproliferative glomerular disease? Boyce, Giddens, and Seifert (1981) Rhesus macaques (Macaca mulatta)…”

Spontaneous glomerular mesangial lesions in common marmoset monkeys (Callithrix jacchus): a benign non‐progressive glomerulopathy

“…Spontaneous renal lesions have been reported in a range of Old World and New World primates , including the common marmoset monkey . The nature of these has not been fully characterized, but in some cases, they have been attributed as a significant cause or contributor to animal death.…”

“…The development of a marmoset model of solid organ (particularly kidney) transplantation may be utilized to test clinically relevant therapies. As a prerequisite for this work, our group and others have developed a broad range of techniques including the rapid genotyping of marmoset major histocompatibility complex class II genes [32,33], the propagation of dendritic cells from Spontaneous renal lesions have been reported in a range of Old World [15,18,39] and New World primates [3,17,31,39,41], including the common marmoset monkey [4-10, 19, 35, 37]. The nature of these has not been fully characterized, but in some cases, they have been attributed as a significant cause or contributor to animal death.…”

Spontaneous Mesangioproliferative Glomerulonephritis in Pigtailed Macaques (Macaca nemestrina)

“…The pigtailed macaque (Macaca nemesfrina) is an important primate in the research programs at the Regional Primate Research Center (RPRC) at the University of Washington. We have reported elsewhere in this Symposium [5] that glomerulonephritis is an important disease in this species. Because spontaneous glomerular disease could compromise the results of some studies and because the chronic catheterization used in many RPRC studies can induce immune-complex glomerulonephritis [7], it was necessary to evaluate the extent and nature of spontaneous glomerular disease found in our captive pigtail macaques.…”