Renal Drug Delivery With Low-Molecular-Weight Proteins: The Effect of Charge Modifications on the Body Distribution of Drug-Lysozyme Conjugates

Kok, Robbert J.; Grijpstra, F.; Nederhoed, K. H.; Moolenaar, Frits; Zeeuw, Dick de; Meijer, Dirk K. F.

doi:10.1080/107175499267093

Cited by 8 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…112 Proteins such as CD47 (ref. 37) may confer the BLG-based vehicles with "stealth" properties, allowing it to release benecial compounds for a prolonged period in the circulation system. These "smart" delivery vehicles may be of great interest in contemporary food and pharmaceutical industries.…”

Section: Discussionmentioning

confidence: 99%

“…Other strategies such as modication with CD47 (an integrinassociated protein that acts as a marker of "self" in the blood), 36 modulation of mechanical properties, engineering particle morphology, and hitchhiking on red blood cells, have been developed to sustain the circulation as well. 37 The nal step for the delivery is the uptake by target cells. For bioactives that do not require site-specic delivery, their cellular uptake could be improved by carefully tuning the surface properties of the delivery vehicles.…”

Section: Key Factors For Designing Encapsulation and Delivery Systemsmentioning

confidence: 99%

See 1 more Smart Citation

Beta-lactoglobulin-based encapsulating systems as emerging bioavailability enhancers for nutraceuticals: a review

Teng

Wang

2015

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Key Factors For Designing Encapsulation and Delivery Systemsmentioning

confidence: 99%

Beta-lactoglobulin-based encapsulating systems as emerging bioavailability enhancers for nutraceuticals: a review

Teng

Wang

2015

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…The high kidney uptake could be explained by the presence of more positively charged residues. 46,47 Although high kidney uptake can lead to harmful doses, similar uptake has been observed with the commonly used PSMA ligand PSMA I&T, 48 which does not necessarily exclude [ 18 F]-[ nat Lu]Lu-(SiFA)SeFe-rhTATE3 from possible use for clinical imaging. Based on the kidney-to-liver ratio, renal excretion was clearly favored and the low bone uptake confirmed good in vivo stability.…”

Section: ■ Introductionmentioning

confidence: 96%

(SiFA)SeFe: A Hydrophilic Silicon-Based Fluoride Acceptor Enabling Versatile Peptidic Radiohybrid Tracers

Deiser,

Fenzl,

König

et al. 2024

J. Med. Chem.

View full text Add to dashboard Cite

The radiohybrid (rh) concept to design targeted (and chemically identical) radiotracers for imaging or radionuclide therapy of tumors has gained momentum. For this strategy, a new bifunctional Silicon-based Fluoride Acceptor (SiFA) moiety (SiFA)SeFe was synthesized, endowed with improved hydrophilicity and high versatility of integration into rh-compounds. Preliminary radiolabeling and stability studies under different conditions were conducted using model bioconjugate peptides. Further, three somatostatin receptor 2 (sstR2)-targeted rh-compounds ((SiFA)SeFe-rhTATE1–3, TATE = (Tyr3)-octreotate) were developed. Compound (SiFA)SeFe-rhTATE3, enables labeling with 18F for PET imaging or chelation of 177Lu for therapy. The rh-compounds possess comparable receptor binding affinity and in vitro performance as good as the clinically proven gold standards. SstR2-specificity was further shown for (SiFA)SeFe-rhTATE2 using the chicken chorioallantoic membrane (CAM) model. The biodistribution of two compounds in mice showed high accumulation in tumors and excretion via the kidneys, demonstrating the clinical applicability of the (SiFA)SeFe moiety.

show abstract

“…Bioconjugates generally aim at the exploitation of the properties of the biopolymeric material at which the drug is attached (Kok et al, 1999). The scientific literature is rich of examples of drug-polymer conjugates: some of them are represented by chitosan-drug conjugates, in which the highly biocompatible and biodegradable natural occurring polysaccharide bears therapeutic molecules, like methotrexate, through covalent linkage (Fattahi et al, 2015), or by dextran-catechin grafted conjugates (Vittorio et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of sericin-based conjugates by click chemistry: enhancement of sunitinib bioavailability and cell membrane permeation

et al. 2017

View full text Add to dashboard Cite

Sericin is a natural protein that has been used in biomedical and pharmaceutical fields as raw material for polypeptide-based drug delivery systems (DDSs). In this paper, it has been employed as pharmaceutical biopolymer for the production of sunitinib-polypeptide conjugate. The synthesis has been carried out by simple click reaction in water, using the redox couple L-ascorbic acid/hydrogen peroxide as a free radical grafting initiator. The bioconjugate molecular weight (50 kDa5Mw5 75 kDa) was obtained by SDS-PAGE, while the spectroscopic characteristics have been studied in order to reveal the presence of grafted sunitinib. In both FT-IR and UV/Vis spectra, signals corresponding to sunitinib functional groups have been identified. Since sunitinib is an anticancer drug characterized by low bioavailability and low permeability, the bioconjugation aimed at their enhancement. In vitro studies demonstrated that bioavailability has been increased to almost 74%, compared with commercial formulation. Also cell membrane permeability has been augmented in in vitro tests, in which membrane models have been used to determine the lipid membrane/physiological fluid partition coefficient (Kp). The log(Kp) value of the bioconjugate was increased to over 4. This effect resulted in a three-fold decrease of IC 50 value against MCF-7 cells.

show abstract

Renal Drug Delivery With Low-Molecular-Weight Proteins: The Effect of Charge Modifications on the Body Distribution of Drug-Lysozyme Conjugates

Cited by 8 publications

References 35 publications

Beta-lactoglobulin-based encapsulating systems as emerging bioavailability enhancers for nutraceuticals: a review

Beta-lactoglobulin-based encapsulating systems as emerging bioavailability enhancers for nutraceuticals: a review

(SiFA)SeFe: A Hydrophilic Silicon-Based Fluoride Acceptor Enabling Versatile Peptidic Radiohybrid Tracers

Synthesis of sericin-based conjugates by click chemistry: enhancement of sunitinib bioavailability and cell membrane permeation

Contact Info

Product

Resources

About