Renal dysfunction in acute stroke: an independent predictor of long-term all combined vascular events and overall mortality

Tsagalis, George; Akrivos, Theodore; Alevizaki, Maria; Manios, Efstathios; Stamatellopoulos, Kimon; Laggouranis, A.; Vemmos, Konstantinos

doi:10.1093/ndt/gfn471

Cited by 168 publications

(165 citation statements)

References 31 publications

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“…Similar results were found by Hoshino and colleagues 19 in their study among stroke patients with mild to moderate renal dysfunction. Tsagalis et al, 20 observed a similar rates (28%) of renal dysfunction in acute stroke patients suggesting a significant prevalence of CKD in stroke sufferers .…”

mentioning

confidence: 78%

Baseline Renal Dysfunction in Acute Ischemic Stroke Patients: Prevalence and Impact on Early Mortality.

Mahmoud.¹,

Badawy.²,

Shehta³

et al. 2017

IJAR

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confidence: 78%

Baseline Renal Dysfunction in Acute Ischemic Stroke Patients: Prevalence and Impact on Early Mortality.

Mahmoud.¹,

Badawy.²,

Shehta³

et al. 2017

IJAR

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“…46 This study showed that although estimated GFR was associated with increased risk, the risk was lower than that observed for cystatin C. 46 Possible reasons for the stronger association between serum cystatin C and mortality compared to creatinine and estimated GFR are not completely clear, but are likely due, at least in part, to non-GFR determinants of serum cystatin C. 47 In previous studies, it was documented that renal dysfunction is independent predictor of short-and long-term mortality in patients with stroke. [9][10][11][12][13][14] In most studies, creatinine or estimated GFR based on creatinine were used to define renal dysfunction. The predictive value of cystatin C has not been fully established in patients suffering from ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8] In several studies, higher prevalence of renal dysfunction in patients with ischemic stroke was reported. 9,10 Furthermore, renal dysfunction was also an independent predictor of mortality in patients with stroke. 9,[11][12][13] Patients with renal dysfunction are also at greater risk of future ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

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Cystatin C, creatinine, estimated glomerular filtration, and long-term mortality in stroke patients

2013

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Renal dysfunction is associated with mortality in patients after ischemic stroke. Cystatin C is a potentially superior marker of renal function compared to creatinine and estimated glomerular filtration rate (GFR). In our observational cohort study, 390 Caucasian patients suffered from acute ischemic stroke (mean age 70.9 years; 183 women and 207 men) were included and prospectively followed up to maximal 56 months. Serum creatinine and cystatin C were measured at admission to the hospital; GFR was estimated according to CKD-EPI creatinine and CKD-EPI creatinine/cystatin equations. According to values of serum creatinine, estimated GFR and serum cystatin C patients were divided into quintiles. In the follow-up period, 191 (49%) patients died. For serum cystatin C and estimated GFR based on creatinine and cystatin C, the mortality and the hazard ratios for long-term mortality increased from the first to the fifth quintile nearly linearly. The associations of serum creatinine and estimated GFR categories based on creatinine with long-term mortality were J-shaped. As compared with lowest quintile of serum cystatin C, the fifth quintile was associated with long-term mortality significantly also after multivariate adjustment (age, gender, initial stroke severity, known risk factors for stroke mortality). In contrast, in adjusted analysis serum creatinine and estimated GFR (CKD-EPI creatinine and CKD-EPI creatinine/cystatin) were not associated with long-term mortality. In summary, serum cystatin C was independently and better associated with the risk of long-term mortality in patients suffering from ischemic stroke than were creatinine and estimated GFR using both CKD-EPI equations.

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“…Nearly, one-third of acute stroke patients have renal dysfunction. 18 In this study, CKD was found 26.9% in acute ischemic stroke patients.…”

Section: Discussionmentioning

confidence: 49%

CKD is associated with recurrent ischemia but not with hemorrhagic transformation in acute ischemic stroke patients

Micozkadıoğlu¹,

Özelsancak²,

Gıray

et al. 2013

Renal Failure

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Background: We investigated the associations of Recurrent Ischemic Stroke (RIS) and Hemorrhagic Transformation (HT) with CKD in acute ischemic stroke patients. Method: The subjects were 160 patients, divided into two groups: with eGFR 560 mL/min/1.73 m 2 (CKD), with eGFR !60 mL/min/1.73 m 2 (without CKD). Results: Subjects having DM (p ¼ 0.018), CKD (p ¼ 0.025) and treated with ACEI/ARB (p ¼ 0.039) revealed association with RIS. Regression analysis disclosed only CKD (p ¼ 0.04). Carotid artery stenosis (p ¼ 0.030) and serum calcium levels (p ¼ 0.013) showed significant association with HT. Conclusion: Our results disclosed that CKD could be a risk factor for RIS. There is no relation between CKD and HT.

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Renal dysfunction in acute stroke: an independent predictor of long-term all combined vascular events and overall mortality

Abstract: Renal function on admission appears to be a significant independent prognostic factor for long term mortality and new cardiovascular morbidity over a 10-year period.

Cited by 168 publications

References 31 publications

Baseline Renal Dysfunction in Acute Ischemic Stroke Patients: Prevalence and Impact on Early Mortality.

Baseline Renal Dysfunction in Acute Ischemic Stroke Patients: Prevalence and Impact on Early Mortality.

Cystatin C, creatinine, estimated glomerular filtration, and long-term mortality in stroke patients

CKD is associated with recurrent ischemia but not with hemorrhagic transformation in acute ischemic stroke patients

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