Renal dysfunction in STEMI-patients undergoing primary angioplasty: higher prevalence but equal prognostic impact in female patients; an observational cohort study from the Belgian STEMI registry

Gevaert, Sofie; Bacquer, Dirk De; Evrard, Patrick; Renard, Marc; Beauloye, Christophe; Coussement, Patrick; Raedt, Herbert De; Sinnaeve, Peter; Claeys, Marc J.

doi:10.1186/1471-2369-14-62

Cited by 24 publications

(14 citation statements)

References 24 publications

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“…Additionally, mortality due to MI was more prevalent among females, which was consistent with the results of the studies by Valente and De Luca (21,22). However, some studies have come to controversial results (23,24) mainly because of women's clinical and profile risk factors.…”

Section: Discussionsupporting

confidence: 81%

The Relationship between Serum Hemoglobin and Creatinine Levels and Intra-Hospital Mortality and Morbidity in Acute Myocardial Infarction

Fazlinezhad¹,

Hami²,

Shakeri³

et al. 2015

Int Cardiovasc Res J

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A B S T R A C T Background: Studies have shown that Glomerular Filtration Rate (GFR) and Hemoglobin (Hb) concentrations are two predictive values for ST-elevation Myocardial Infarction (MI) mortality.Objectives: This study aimed to investigate the relationship between GFR and Hb concentrations and intra-hospital mortality and electrocardiographic (ECG) and echocardiographic abnormalities in ST-elevation MI patients admitted to a highly equipped hospital in Mashhad. The results will help define some factors to manage these patients more efficiently. Patients and Methods:This descriptive study aimed to assess the relationship between Hb and GFR concentrations and mortality and morbidity among 294 randomly selected patients with ST-elevation MI. Echocardiography, ECG, and routine laboratory tests, including Hb and creatinine, were performed for all the patients. Then, the data were entered into the SPSS statistical software, version 16 and were analyzed using chi-square, t-test, and ANOVA. P < 0.05 was considered as statistically significant. Results: Intra-hospital mortality rate was 10.5%. Besides, the results showed higher levels of serum blood sugar (P < 0.001), higher levels of creatinine (P < 0.001), lower levels of GFR (P < 0.001), lower ejection fraction (P < 0.001), higher grades of left ventricular diastolic dysfunction (P = 0.002), and lower mean Hb concentration (P = 0.022) in the dead compared to the alive cases. Besides, the patients with mechanical complications had lower Hb levels (P = 0.008). The results showed no significant relationship between creatinine level and mechanical and electrical complications (P = 0.430 and P = 0.095, respectively). However, ejection fraction was significantly associated with GFR (P = 0.016). Conclusions: According to the results, low levels of Hb and GFR could predict mortality caused by ST-elevation MI and ECG abnormalities could notify intra-hospital death. Moreover, lower Hb levels were associated with mechanical complications and could be used as a parameter for diagnosis of high-risk patients.

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Section: Discussionsupporting

confidence: 81%

The Relationship between Serum Hemoglobin and Creatinine Levels and Intra-Hospital Mortality and Morbidity in Acute Myocardial Infarction

Fazlinezhad¹,

Hami²,

Shakeri³

et al. 2015

Int Cardiovasc Res J

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“…These data are supported by previous reports. Both Gevaert et al and Sederholm Lawesson et al showed that female gender was independently associated with renal dysfunction at admission in PCI‐treated patients. Furthermore, Sciagra et al showed that among 460 patients with acute myocardial infarction, there was a significant gender‐related difference with left ventricular ejection fraction decreasing more sharply in females than in males.…”

Section: Discussionmentioning

confidence: 98%

Gender‐Related Mortality and In‐Hospital Complications Following ST‐Segment Elevation Myocardial Infarction: Data From a Primary Percutaneous Coronary Intervention Cohort

Laufer‐Perl

Shacham

Letourneau-Shesaf

et al. 2015

Clinical Cardiology

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Background:The increased mortality related to female gender in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PPCI) has been reported from various patient cohorts and treatment strategies with controversial results. In the present work, we evaluated the impact of female gender on mortality and in-hospital complications among a specific subset of consecutive STEMI patients managed solely by PPCI. Hypothesis: Female gender is not an independent predicor for mortality among STEMI patients. Methods: We performed a retrospective, single-center observational study that included 1346 consecutive STEMI patients undergoing PPCI, of which 1075 (80%) were male. Patient's records were evaluated for 30-day mortality, in-hospital complications, and long-term mortality over a mean period of 2.7 ± 1.6 years. Results: Compared with males, females were older (69 ± 13 vs 60 ± 13 years, P < 0.001), had a significantly higher rate of baseline risk factors, and had prolonged symptom duration (460 ± 815 minutes vs 367 ± 596 minutes, P = 0.03). Females suffered from more in-hospital complications and had higher 30-day mortality (5% vs 2%, P = 0.008) as well as higher overall mortality (12.5% vs 6%, P < 0.001). In spite of the significant mortality risk in unadjusted models, a multivariate adjusted Cox regression model did not demonstrate that female gender was an independent predictor for mortality among STEMI patients. Conclusions: Among patients with STEMI treated by PPCI, female gender is associated with a higher 30-day mortality and complications rates compared to males. Following multivariate analysis, female gender was not a significant predictor of long-term death following STEMI.

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“…Our finding has some potential clinical implications. We speculate that early nephroprotective strategies for contrast‐induced renal injury, such as low volume of contrast, crystalloid infusions, radial approach to prevent bleeding and other complications, measures for optimal hemodynamics, and discontinuation of nephrotoxic drugs, might provide a significant long‐term benefit . The possibility of early identification of the patients who will probably develop DRF is clinically important.…”

Section: Discussionmentioning

confidence: 99%

Influence of minor deterioration of renal function after PCI on outcome in patients with ST‐elevation myocardial infarction

Kanic

Suran

Vollrath

et al. 2017

J Interven Cardiology

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Renal dysfunction in STEMI-patients undergoing primary angioplasty: higher prevalence but equal prognostic impact in female patients; an observational cohort study from the Belgian STEMI registry

Cited by 24 publications

References 24 publications

The Relationship between Serum Hemoglobin and Creatinine Levels and Intra-Hospital Mortality and Morbidity in Acute Myocardial Infarction

The Relationship between Serum Hemoglobin and Creatinine Levels and Intra-Hospital Mortality and Morbidity in Acute Myocardial Infarction

Gender‐Related Mortality and In‐Hospital Complications Following ST‐Segment Elevation Myocardial Infarction: Data From a Primary Percutaneous Coronary Intervention Cohort

Influence of minor deterioration of renal function after PCI on outcome in patients with ST‐elevation myocardial infarction

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