Renal dysfunction is already evident within the first month of life in Australian Indigenous infants born preterm

Sutherland, Megan R.; Chatfield, Mark D.; Davison, Belinda; Vojisavljevic, Danica; Kent, Alison; Hoy, Wendy E.; Singh, Gurmeet; Black, Mary Jane

doi:10.1016/j.kint.2019.07.015

Cited by 7 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8,9 Previous studies have also highlighted that the antecedents of chronic kidney disease start early at birth or even antenatally in Aboriginal and Torres Strait Islander children and is likely contributed to by a complex interplay of maternal factors, low birth weight, reduced nephron mass, socioeconomic disadvantage, and lifestyle factors. 1,10,11 Our study confirms that increased incidence starts early in life. We recommend early preventative measures as a key aspect of reducing the CKD and ESKD burden.…”

Section: Discussionsupporting

confidence: 83%

Rising Incidence of End-Stage Kidney Disease and Poorer Access to Kidney Transplant Among Australian Aboriginal and Torres Strait Islander Children and Young Adults

Chaturvedi

Ullah

LePage

et al. 2021

Kidney International Reports

View full text Add to dashboard Cite

Introduction Details of the pediatric population with end-stage kidney disease (ESKD) in Australia and New Zealand have been published previously. There is, however, a paucity of studies exploring the trends in incidence, etiology, renal replacement therapy (RRT) modality, and transplant access among the Aboriginal and Torres Strait Islander children and young adults (ATCYAs) residing in Australia. Methods An observational study was undertaken and data on Australian patients who commenced RRT at ≤24 years of age between 1963 and 2017 were extracted from the Australian and New Zealand Dialysis and Transplant Registry (ANZDATA). The incidence and prevalence rates were restricted from 1997 to 2017 because of the unavailability of Aboriginal– and Torres Strait Islander status–specific census data before 1997. Results A total of 3629 children and young adults received RRT during the observation period, including 178 (4.9%) who identified as ATCYAs and 3451 (95.1%) other children and young adults (OCYAs). Compared with OCYAs, incident rates have risen among ATCYAs since 2000, with the biggest rise for young adults 20 to 24 years of age. Fewer ATCYAs received a kidney transplant compared with OCYAs (56.2% vs. 89.3%, P < 0.001). Pre-emptive kidney transplants were less common in ATCYAs compared with OCYAs (3.4% vs. 16.8%, P < 0.001). Living related donor transplants were less common among ATCYAs than OCYAs (10.7% vs. 35.9%, P < 0.001). Conclusions Our study shows rising incident rates and poorer access to kidney transplantation among ATCYAs in Australia. The reasons for this health care disparity and barriers to transplantation need to be explored further and must be addressed.

show abstract

Section: Discussionsupporting

confidence: 83%

Rising Incidence of End-Stage Kidney Disease and Poorer Access to Kidney Transplant Among Australian Aboriginal and Torres Strait Islander Children and Young Adults

Chaturvedi

Ullah

LePage

et al. 2021

Kidney International Reports

View full text Add to dashboard Cite

show abstract

“…A suboptimal intrauterine environment results in lower nephron endowment 27,28 and nephron development is impaired with prematurity, which commonly accompanies lower birthweights. [27][28][29][30][31][32] Moreover, reduced or frankly "impaired" postnatal kidney hypertrophy is widely documented in low birthweight infants and children. 33,34 In our dataset, the failure of eGFR in low birthweight persons to increase between the 2 examinations, despite increasing age and body mass increase, might reflect restriction of the kidney hypertrophy that usually accompanies advancement into adult life.…”

Section: Adult Weight Waistmentioning

confidence: 99%

Birthweight and the Prevalence, Progression, and Incidence of CKD in a Multideterminant Model in a High-Risk Australian Aboriginal Community

Hoy

Swanson

Mott

2021

Kidney International Reports

Self Cite

View full text Add to dashboard Cite

Introduction: We have previously showed that albuminuria was associated with low birthweight in young adults in a remote Australian Aboriginal community that has high rates of kidney disease. Here we describe the association of birthweight with incidence and progression of kidney disease over time.Methods: Among 695 members of an Aboriginal community with recorded birthweights, urine albumin creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were measured at ages 5 to 40 years, and follow-up values were measured or imputed again a median of 11.6 years later. Prevalence of markers on each occasion and change over time were evaluated in the context of birthweights and other potentially significant factors.Results: On the second screen, ACR was inversely and significantly correlated with birthweight and eGFR was directly correlated with birthweight. Increases in ACR and in proportions of persons who developed new-onset (incident) albuminuria between screens were higher in those of lower birthweights (<2.5 kg). Proportions of persons who lost $20% of their baseline eGFR were higher in the lower birthweight groups. Lower birthweights also amplified elevations of ACR associated with other risk factors, specifically higher body mass indexes (BMIs) and a prior history of poststreptococcal glomerulonephritis (PSGN). At both screens, progressively higher levels of ACR beyond the mid-microalbuminuria range were correlated with lower levels of eGFR.Conclusions: Lower birthweight contributes to an excess of kidney disease and its progression in this population. Because an excess of low birthweight and episodes of PSGN are eminently preventable, substantial containment of kidney disease is feasible.

show abstract

“…It is the leading cause of admission to the neonatal unit and perinatal mortality. [5][6][7] PTB is associated with frequent use of health services during child and adulthood 6 and is a key driver of ethnic disparities in the burdens of asthma, 8 renal dysfunction, 9 and sudden infant death syndrome. 10 First Nations children that were born preterm face delays with childhood immunization 11 and have higher rates of infant mortality after discharge from the neonatal unit, 12 suggesting discrepancies in access to, and provision of, care within the health system.…”

Section: Introductionmentioning

confidence: 99%

A better start to life: Risk factors for, and prevention of, preterm birth in Australian First Nations women – A narrative review

Brown

Langston-Cox

Unger

2021

Intl J Gynecology & Obste

View full text Add to dashboard Cite

The unacceptable discrepancies in health outcomes between First Nations and non‐Indigenous Australians begin at birth. Preterm birth (birth before 37 completed weeks of gestation) is a major contributor to adverse short‐ and long‐term health outcomes and mortality. Australian First Nations infants are more commonly born too early. No tangible reductions in preterm births have been made in First Nations communities. Factors contributing to high preterm birth rates in Australian First Nations infants are reviewed and interventions to reduce preterm birth in Australian First Nations women are discussed. More must be done to ensure Australian First Nations infants get a better start to life. This can only be achieved with ongoing and improved research in partnership with Australian First Nations peoples.

show abstract

Renal dysfunction is already evident within the first month of life in Australian Indigenous infants born preterm

Cited by 7 publications

References 27 publications

Rising Incidence of End-Stage Kidney Disease and Poorer Access to Kidney Transplant Among Australian Aboriginal and Torres Strait Islander Children and Young Adults

Rising Incidence of End-Stage Kidney Disease and Poorer Access to Kidney Transplant Among Australian Aboriginal and Torres Strait Islander Children and Young Adults

Birthweight and the Prevalence, Progression, and Incidence of CKD in a Multideterminant Model in a High-Risk Australian Aboriginal Community

A better start to life: Risk factors for, and prevention of, preterm birth in Australian First Nations women – A narrative review

Contact Info

Product

Resources

About