Renal Effects of Exposure to Metals

Barregård, Lars; Elinder, Carl‐Gustaf

doi:10.1016/b978-0-444-59453-2.00017-2

Cited by 9 publications

(6 citation statements)

References 163 publications

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“…In terms of age, smoking and hypertension, the high risk ratios were observed in women, indicating that the present information for cardiovascular disease did not contradict the common knowledge for these risk factors. Recent studies of an American cohort (Tellez-Plaza et al, 2012;Tellez-Plaza et al, 2013), Swedish cohort (Barregard & Elinder, 2015) and Japanese cohort (Li et al, 2011) In terms of parity, a recent meta-analysis indicated that participants with no parity had a higher risk of all-cause mortality compared with participants with parity (Zeng et al, 2016). Therefore, to evaluate the effect of parity on the significant relationship between R-Cd and mortality, we re-analyzed risk ratios by using a new statistical model added for parity.…”

Section: Resultsmentioning

confidence: 99%

“…In terms of age, smoking and hypertension, the high risk ratios were observed in women, indicating that the present information for cardiovascular disease did not contradict the common knowledge for these risk factors. Recent studies of an American cohort (Tellez-Plaza et al, 2012;Tellez-Plaza et al, 2013), Swedish cohort (Barregard & Elinder, 2015) and Japanese cohort (Li et al, 2011) have indicated that blood Cd or U-Cd increased the mortality risk for cardiovascular disease. On the other hand, it was reported that a higher U-Cd was significantly related to lower mortality risk for coronary heart disease (Menke, Muntner, Silbergeld, Platz, & Guallar, 2009).…”

Section: Resultsmentioning

confidence: 99%

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Relationship between mortality and rice cadmium concentration in inhabitants of the polluted Jinzu River basin, Toyama, Japan: A 26 year follow‐up

Nogawa

Suwazono

Nishijo

et al. 2018

J of Applied Toxicology

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The aim of this study was to investigate the relationship between mortality and rice cadmium (Cd) concentration in inhabitants of a polluted area in Japan. The target subjects were inhabitants of the Jinzu River basin who participated in health examinations for screening of renal dysfunction from 1979 to 1984. The mean rice Cd concentration in each hamlet was used as an index of the Cd exposure. We conducted a 26 year follow-up survey in 3281 inhabitants (1544 men and 1737 women) whose data regarding the rice Cd concentration were available. Mortality risk ratios for all and specific causes were estimated after adjustments for age at baseline, smoking status and history of hypertension using a Cox hazard model or Fine and Gray competing risks regression model. The mortality risk ratios of rice Cd concentration (+0.1 ppm) for all causes in women were significantly increased (risk ratio: 1.04). Furthermore, the relative risks of rice Cd concentration for kidney and urinary tract disease, renal diseases, renal failure and toxic effects of cadmium were significantly increased in both sexes. These findings indicated that increased rice Cd concentration decreased the prognosis for life over a long-term observation in women. This result provides important information for determining the worldwide standard for allowable rice Cd concentration.

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Section: Resultsmentioning

confidence: 99%

“…In terms of age, smoking and hypertension, the high risk ratios were observed in women, indicating that the present information for cardiovascular disease did not contradict the common knowledge for these risk factors. Recent studies of an American cohort (Tellez-Plaza et al, 2012;Tellez-Plaza et al, 2013), Swedish cohort (Barregard & Elinder, 2015) and Japanese cohort (Li et al, 2011) have indicated that blood Cd or U-Cd increased the mortality risk for cardiovascular disease. On the other hand, it was reported that a higher U-Cd was significantly related to lower mortality risk for coronary heart disease (Menke, Muntner, Silbergeld, Platz, & Guallar, 2009).…”

Section: Resultsmentioning

confidence: 99%

Relationship between mortality and rice cadmium concentration in inhabitants of the polluted Jinzu River basin, Toyama, Japan: A 26 year follow‐up

Nogawa

Suwazono

Nishijo

et al. 2018

J of Applied Toxicology

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“…It was suggested that arsenic exposure from contaminated agrochemical formulations might be involved in the pathogenesis of CKDu. However, albeit inorganic arsenic is severely toxic and may cause several types of systemic toxicity, kidney toxicity, in particular in the form of lowered eGFR, has rarely been reported [44]. Furthermore monitoring of exposure to the toxic form of arsenic (i.e.…”

Section: Alternative Hypothesismentioning

confidence: 99%

Mesoamerican Nephropathy (MeN): A ‘New’ Chronic Kidney Disease related to Occupational Heat Exposure with Repeated Deprivation of Salts and Water

Elinder¹

2015

Int J Nephrol Kidney Failure

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“…Ni, Co, Mn, and Cr can irritate the respiratory tract and impair lung function [3][4][5]. As, Hg, Pb, Cd, and Mn are nephrotoxic metals [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“Assessing exposure of printing factory workers in thailand to selected heavy metals using urine and hair as non-invasive matrices”

et al. 2023

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Background There are few thorough studies on the extent and inter-element relationships of heavy metal contamination in printing factory workers, especially in developing countries. The objective of this study was to determine the levels of eight heavy metals, including arsenic (As), cadmium (Cd), chromium (Cr), nickel (Ni), cobalt (Co), lead (Pb), mercury (Hg), and manganese (Mn), in urine and scalp hair of printing industry workers, and assess inter-element correlations. Methods We examined a total of 85 urine samples and 85 scalp hair samples (3 cm hair segments taken from near the scalp) in 85 printing workers from a printing house in Bangkok, Thailand. We used an interviewer-administered questionnaire about participants’ printing techniques, work characteristics, and work environment. Urine and scalp hair samples were analyzed for levels of each element using the inductively coupled plasma optical emission spectrometry (ICP-OES) technique. Results As, Cd, Cr, Ni, Pb were detected in urine with the geometric mean concentration range of 0.0028–0.0209 mg/L, and Hg, Pb, Ni, Cd, Co, Mn, Cr were detected in hair samples (0.4453–7.165 mg/kg dry weight) of printing workers. The geometric mean Ni level was significantly higher in the urine of production line workers than back-office personnel (0.0218 mg/L vs. 0.0132 mg/L; p = 0.0124). The other elements did not differ significantly between production line and back-office workers in either urine or hair. There was also a strong, statistically significant positive correlation between Ni and Co levels in hair samples of workers (r = 0.944, p < 0.0001). Conclusions Average concentrations of most of the metals in urine and hair of printing workers were found to be above the upper reference values. The significantly higher concentrations of Ni in production line workers might be due to more exposure to printed materials. A strong inter-element correlation between Ni and Co in hair samples can increase stronger health effects and should be further investigated. This study reveals possible dependencies and impact interactions of heavy metal exposure in printing factory workers.

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Renal Effects of Exposure to Metals

Cited by 9 publications

References 163 publications

Relationship between mortality and rice cadmium concentration in inhabitants of the polluted Jinzu River basin, Toyama, Japan: A 26 year follow‐up

Relationship between mortality and rice cadmium concentration in inhabitants of the polluted Jinzu River basin, Toyama, Japan: A 26 year follow‐up

Mesoamerican Nephropathy (MeN): A ‘New’ Chronic Kidney Disease related to Occupational Heat Exposure with Repeated Deprivation of Salts and Water

“Assessing exposure of printing factory workers in thailand to selected heavy metals using urine and hair as non-invasive matrices”

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