Renal Effects of Preeclampsia

Jen, Kuang-Yu; Lászik, Zoltán

doi:10.5772/31014

Cited by 4 publications

(5 citation statements)

References 30 publications

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“…Differences between these results and our data suggest that the hypoxia-stressed animals we used were not completely accurate models of preeclampsia. Although calcium excretion in urine is not a traditional symptom of preeclampsia [3,54,55], there is some evidence showing calcium excretion [56,57]. Urinary calcium excretion and blood gas levels are also indicative of metabolic acidosis, as previously described [58].…”

Section: Discussionmentioning

confidence: 90%

Change of Genes in Calcium Transport Channels Caused by Hypoxic Stress in the Placenta, Duodenum, and Kidney of Pregnant Rats1

Yang

Choi

et al. 2013

Biology of Reproduction

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Preeclampsia is a pregnancy-specific disease characterized by concurrent development of hypertension, proteinuria, and oxidative stress in the placenta. In this study, we induced hypoxic stress in rats during pregnancy to reproduce physiological conditions associated with preeclampsia. The maternal weight of hypoxic pregnant rats was lower than that of normoxic animals. The level of calcium ions were also increased in urine collected from the hypoxic animals. In contrast, urinary concentrations of sodium, chloride, and potassium ions declined in hypoxic rats, and developed to proteinuria. The expression of genes known as two biomarkers, sFLT1 (for preeclampsia) and HIF-1alpha (for hypoxia), were highly induced in the placenta, duodenum, and kidney by hypoxic stress. The overexpression of sFLT1 and HIF-1alpha demonstrated that our experimental conditions closely mimicked ones that are associated with preeclampsia. In the present study, we measured the expression of calcium transporters (TRPV5, TRPV6, PMCA1, NCKX3, NCX1, and CaBP-9k) in the placenta, duodenum, and kidney under hypoxic conditions on Gestational Day 19.5 in rats. Placental TRPV5, TRPV6, and PMCA1 expression was up-regulated in the hypoxic rats, whereas the levels of NCX1 and CaBP-9k were unchanged. In addition, NCKX3 expression was increased in the placenta of hypoxic rats. Duodenal expression of CaBP-9k, TRPV5, TRPV 6, and PMCA1 was decreased in the hypoxic rats, whereas levels of NCXs were not altered. Renal expression of NCKX3 and TRPV6 was increased, whereas NCX1 was decreased in the hypoxic rats compared to the normoxic controls. Taken together, these results indicate that physiological changes observed in the hypoxic rats were similar to ones associated with preeclampsia. Expression of calcium transport genes in the placenta, duodenum, and kidney perturbed by hypoxic stress during pregnancy may cause calcium loss in the urine, and thereby induce calcium-deficient characteristics of preeclampsia.

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Section: Discussionmentioning

confidence: 90%

Change of Genes in Calcium Transport Channels Caused by Hypoxic Stress in the Placenta, Duodenum, and Kidney of Pregnant Rats1

Yang

Choi

et al. 2013

Biology of Reproduction

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“…However, edema, as was seen in our patient, is often associated with pre-eclampsia. The typical patient with pre-eclampsia will have mild proteinuria, but nephrotic-range proteinuria and mild hematuria can be seen in more severe cases of pre-eclampsia, and this may suggest a higher risk for complications [5]. …”

Section: Discussionmentioning

confidence: 99%

“…Immunofluorescence studies may show the deposition of fibrin and fibrinogen derivatives. Electron microscopy confirms endotheliosis and loss of the endothelial fenestrae, and there may be focal or widespread effacement of the foot processes of the podocytes [5, 6]. …”

Section: Discussionmentioning

confidence: 99%

When listening for hoofbeats, sometimes there are zebras—an interesting case of a teenager with edema and high blood pressure: Answers

Taasoobshirazi

Batisky

2014

Pediatr Nephrol

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“…HELLP (hemolysis, elevated liver enzymes, and low platelet) syndrome is a life-threatening form of preeclampsia and is seen in approximately 10–20% of severe preeclamptic pregnant women. High liver enzymes and thrombocytopenia were seen due to systemic end-organ damage and microangiopathic hemolysis in HELLP aids to diagnose as laboratory findings [ 9 ]. HT during pregnancy plays a vital role in cardiovascular diseases accompanied by maternal hemodynamic disorders [ 10 ].…”

Section: Highlight Key Pointsmentioning

confidence: 99%

The effect of thromboembolic prophylaxis after cesarean section in patients with hypertensive disorders

YILMAZ¹

2021

North Clin Istanbul

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OBJECTIVE This study aims to compare the effect of thromboembolic prophylaxis in patients diagnosed with hypertensive disorders of pregnancy undergoing cesarean section. METHODS Three hundred and eighty-six patients were included in the study. The patients were divided into groups according to the type of hypertensive disorders of pregnancy and whether thromboembolism prophylaxis was applied or not. The thromboembolic event incidence and other pregnancy outcomes were compared. RESULTS Nonadministration of thromboprophylaxis was recorded in 210 patients. Eleven patients had thromboembolic events (5%). Among 176 patients who received thromboprophylaxis, only two patients (1%) had a thromboembolic event (p<0.05). CONCLUSION There is an increased tendency to thromboembolism in pregnancy. The incidence increases in the presence of hypertension accompanying pregnancy. In our study, the importance of thromboembolism prophylaxis on peri-postnatal complications in patients with hypertensive disorders of pregnancy was emphasized.

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Renal Effects of Preeclampsia

Cited by 4 publications

References 30 publications

Change of Genes in Calcium Transport Channels Caused by Hypoxic Stress in the Placenta, Duodenum, and Kidney of Pregnant Rats1

Change of Genes in Calcium Transport Channels Caused by Hypoxic Stress in the Placenta, Duodenum, and Kidney of Pregnant Rats1

When listening for hoofbeats, sometimes there are zebras—an interesting case of a teenager with edema and high blood pressure: Answers

The effect of thromboembolic prophylaxis after cesarean section in patients with hypertensive disorders

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