Renal failure, comorbidity and mortality in preterm infants

Csaicsich, Dagmar; Russo-Schlaff, Nina; Messerschmidt, Agnes; Weninger, M.; Pollak, Arnold; Aufricht, Christoph

doi:10.1007/s00508-008-0941-5

Cited by 35 publications

(48 citation statements)

References 21 publications

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“…The reported incidence of AKI in newborn infants admitted to NICUs has been reported to vary between 3.4 and 24%, which is consistent with our findings [4][5][6]. In a study of 359 premature infants born at <37 weeks of GA, Csaicsich et al found that the incidence of AKI was 4.5% among all premature infants and 6.4% among ELBW infants (n=156) [6].…”

Section: Discussionsupporting

confidence: 94%

“…In a study of 359 premature infants born at <37 weeks of GA, Csaicsich et al found that the incidence of AKI was 4.5% among all premature infants and 6.4% among ELBW infants (n=156) [6]. In our study, the incidence of AKI was 12.5% among our 472 ELBW infants.…”

Section: Discussionmentioning

confidence: 61%

“…AKI affects 3.4-24% of all infants who are admitted to the neonatal intensive care units (NICU) [4][5][6]. Several potential risk factors for the development of AKI in neonates have been identified [4,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Risk factors associated with acute kidney injury in extremely low birth weight (ELBW) infants

et al. 2011

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The aim of this study was to determine the incidence, risk factors, and outcome of acute kidney injury (AKI) in extremely low birth weight (ELBW) infants. In a case-control study, medical records of all ELBW infants who were admitted to our Neonatal Intensive Care Unit (NICU) between 1 January 2000 and 31 January 2008 were reviewed. During the study period, 12.5% (59/472) of all ELBW infants developed AKI. Forty-six infants with available medical records were matched to 46 controls. The mean gestational age and birth weight of infants with AKI and their controls were 24.7 ± 1.8 vs. 24.9 ± 1.9 weeks (p = 0.61) and 614 ± 128 vs. 616 ± 127 g (p = 0.93), respectively. Infants with AKI had a higher mean airway pressure, a lower mean arterial blood pressure, and higher exposure to cefotaxime than their controls. Infants with AKI also had an increased mortality in comparison to their controls [33/46 (70%) vs. 10/46 (22%), respectively; p < 0.0001), and oliguric patients had a higher mortality than nonoliguric patients [31/38 (81%) vs. 2/8 (25%), respectively, p = 0.003]. Based on our results, we conclude that a high mean airway pressure, low blood pressure, and the use of cefotaxime are associated with renal failure in ELBW infants. AKI in ELBW infants is also associated with an increased mortality, especially in the presence of oliguria.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 61%

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Risk factors associated with acute kidney injury in extremely low birth weight (ELBW) infants

et al. 2011

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“…It occurs in 44% -78% of patients with neonatal septicemia, and the risk is 2 -3 times higher in these patients, compared to those without AKI (3,14). In the present study, about 15% of patients died and 85% were discharged.…”

Section: Serum Phmentioning

confidence: 67%

“…However, intrinsic and postrenal failure have been reported in 11% -52% and 3% of patients, respectively (5,9,14). 4 Arch Pediatr Infect Dis.…”

Section: Serum Phmentioning

confidence: 99%

Predictive Factors for Acute Renal Failure in Neonates with Septicemia

Nickavar

Khosravi

Mazouri

2017

Arch Pediatr Infect Dis

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Objectives: Septicemia is an important cause of acute kidney injury (AKI) in neonates admitted to neonatal intensive care units. The aim of this study was to identify the predictive factors for AKI in neonates with culture-proven septicemia.Methods: Medical records of 138 newborns with septicemia were evaluated in 2 groups with (n, 65) and without (n, 73) AKI. Results:The mean age at diagnosis of AKI was 11.31 ± 9.92 days. AKI was more common in neonates with lower gestational age, birth weight, age, blood pressure, platelet count, and serum pH at admission. Moreover, AKI was associated with an increased incidence of intubation at birth, inotrope treatment, shock, disseminated intravascular coagulation (DIC), mechanical ventilation, and morality. Gestational age, initial serum pH, and DIC were the only independent predictors of AKI in the multivariate analysis. In addition, serum pH at admission was the most accurate laboratory marker for the prediction of AKI with 83% sensitivity and 60% specificity. Conclusions:Monitoring of renal function is highly recommended in low-birth-weight infants with severe septicemia.

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