Renal failure during intermittent rifampicin therapy

Chan, Weng C.; O'mahoney, M. G.; Yu, D. Y. C.; Yu, Rongjie

doi:10.1016/0041-3879(75)90051-3

Cited by 21 publications

(7 citation statements)

References 6 publications

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“…These reactions cause two different pathologic changes in the kidneys. The deposition of immune complexes in the vessels causes vascular constriction and tubular ischemia, leading to acute tubular necrosis, whereas the deposition of immune complexes in the interstitial area leads to acute interstitial nephritis [22]. Renal biopsies performed in several studies with a total of 106 patients reveal that the most common pathologies are acute interstitial nephritis (54%) and acute tubular necrosis (38%) [4,11-13].…”

Section: Discussionmentioning

confidence: 99%

Acute kidney injury due to anti-tuberculosis drugs: a five-year experience in an aging population

Chang

Chen

et al. 2014

BMC Infect Dis

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BackgroundPatients on anti-tuberculosis treatment may develop acute kidney injury (AKI), but little is known about the renal outcome and prognostic factors, especially in an aging population. This study aimed to calculate the incidence of AKI due to anti-TB drugs and analyze the outcomes and predictors of renal recovery.MethodsFrom 2006 to 2010, patients on anti-TB treatment were identified and their medical records reviewed. Acute kidney injury was defined according to the criteria established by the AKI Network, while renal recovery was defined as a return of serum creatinine to baseline. Predictors of renal recovery were identified by Cox regression analysis.ResultsNinety-nine out of 1394 (7.1%) patients on anti-TB treatment had AKI. Their median age was 68 years and there was male predominance. Sixty (61%) developed AKI within two months of anti-TB treatment, including 11 (11%) with a prior history of rifampin exposure. Thirty (30%) had co-morbid chronic kidney disease or end-stage renal disease. The median time of renal recovery was 39.6 days (range, 1–180 days). Factors predicting renal recovery were the presence of fever, rash, and gastro-intestinal disturbance at the onset of AKI. Sixty-two of the 71 (87%) patients who recovered from AKI had successful re-introduction or continuation of rifampin.ConclusionsRenal function impairment is not a rare complication during anti-TB treatment in an elderly population. The presence of fever and rash may be associated with renal recovery. Rifampin can still be used in most patients who recover from AKI.

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Section: Discussionmentioning

confidence: 99%

Acute kidney injury due to anti-tuberculosis drugs: a five-year experience in an aging population

Chang

Chen

et al. 2014

BMC Infect Dis

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“…4,7 Most acute reactions occur during reintroduction of RIF during therapy though some reports have been during continuous RIF therapy. 6,20 RIFinduced ARF is characterized by tubular necrosis and tubulo-interstitial nephritis. It is known that INH and RIF cause liver toxicity and release of toxic metabolites.…”

Section: Discussionmentioning

confidence: 99%

“…The same has been confirmed in recent case reports from patients undergoing anti-tuberculosis therapy. 5 Chan et al 6 have also explained how renal tubular ischemia is caused by endothelial inflammation as a result of immune complex deposition in the blood vessels. This was confirmed in a recent study in Taiwan showed an incidence of 7.1% among patients undergoing anti-tuberculosis therapy.…”

Section: Introductionmentioning

confidence: 99%

Amelioration of anti-tuberculosis drug induced oxidative stress in kidneys bySpirulina fusiformisin a rat model

Martin

Sabina

2016

Renal Failure

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Nephrotoxicity is a rare complication caused by anti-tuberculosis therapy-induced oxidative stress. The Cyanobacterium Spirulina fusiformis Voronikhin belonging to Oscillatoriaceae family is used traditionally as a source of antioxidants against oxidative stress. We aimed to investigate the efficacy of S. fusiformis in modifying isoniazid (INH) Histological examination of kidneys supported these findings. Results of the in silico analyses showed that selected active components of S. fusiformis interact with LXR and FXR and could be a possible mechanism of action. S. fusiformis rendered protection against anti-tuberculosis drugsinduced oxidative stress in kidney tissues of rats. ARTICLE HISTORY

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“…Although no explanation is available, the fea tures of these cases would suggest that both primary and secondary immunologic responses could play a role in the intolerance reactions induced by rifampicin, and that the hematologic manifestations (thrombopenia and hemolysis) would be mediated by an IgM antibody [3,12,17], Pathological examination of the kidney has been re ported in a few cases. Light microscopy usually has re vealed a picture of non-specific acute tubular necrosis [10,11,18,22]. Fluorescence has usually been negative and only isolated cases with immunoglobulin deposits have been reported [5,18.19,21,22].…”

Section: Discussionmentioning

confidence: 99%

Antirifampicin Antibodies in Acute Rifampicin-Associated Renal Failure

Mauri¹,

Fort²,

Bartolomé³

et al. 1982

Nephron

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5 patients with acute renal failure (3 with thrombopenia and hemolysis) induced by the reintroduction of rifampicin are described. No correlation was found between the severity of clinical manifestations and the total dose taken by the patients. In all but 1 patient, antirifampicin antibodies were detected. Antibodies suggested to be of the IgM class were detected in all 3 patients with hematological disorders. The pattern of non-specific acute tubular necrosis found in the 2 biopsied patients, indistinguishable from that of ischemic origin, raised the possibility of a vascular-mediated damage. In 3 patients, the possibility of a triggering immunoallergic mechanism is discussed.

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Renal failure during intermittent rifampicin therapy

Cited by 21 publications

References 6 publications

Acute kidney injury due to anti-tuberculosis drugs: a five-year experience in an aging population

Acute kidney injury due to anti-tuberculosis drugs: a five-year experience in an aging population

Amelioration of anti-tuberculosis drug induced oxidative stress in kidneys bySpirulina fusiformisin a rat model

Antirifampicin Antibodies in Acute Rifampicin-Associated Renal Failure

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