Renal failure in patients with cirrhosis of the liver

Shear, Leroy; Hall, Phillip M.; Gabuzda, George J.

doi:10.1016/0002-9343(65)90042-2

Cited by 85 publications

(17 citation statements)

References 31 publications

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“…Also, higher incidence of renal failure was seen in patients with decompensated cirrhosis. Similar observations were made by Baldus et al, Shear et al [33][34] No statistically significant correlation could be found between renal failure and glomerular or tubular changes. Immunofluorescence: Direct IF with FITC labelled antisera was done in all thirty cases.…”

Section: Focal Segmental Glomerulosclerosis (Fsgs)supporting

confidence: 90%

The spectrum of renal changes in patients with liver diseases: an immunofluorescent and light microscopic study

2016

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Section: Focal Segmental Glomerulosclerosis (Fsgs)supporting

confidence: 90%

The spectrum of renal changes in patients with liver diseases: an immunofluorescent and light microscopic study

2016

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“…The relationship between the hemodynamic abnormalities demonstrated in these patients and their renal failure must remain speculative. Renal vasoconstriction and systemic hypotension may lead to enhanced tubular reabsorption of filtrate, and the reduction of urine flow could contribute to tubular damage (30,31). The failure of urine output always to increase, despite restoration of apparently normal total renal blood flow, could be explained either by the transient nature of the circulatory response to volume expansion or by the possibility that functional tubular damage had already developed in these patients.…”

Section: Clinical Observationsmentioning

confidence: 99%

Systemic and Renal Hemodynamics in Oliguric Hepatic Failure: Effect of Volume Expansion*

Tristani¹,

Cohn²

1967

J. Clin. Invest.

171

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“…Enhanced renal tubular sodium reabsorption, impaired renal concentrating ability, and abnormal water diuresis have been reported in patients with cirrhosis of the liver (4)(5)(6)(7)(8), and liver failure may be associated with renal failure as in the hepatorenal syndrome (9,10). The exact mechanisms of these renal abnormalities in patients with liver disease are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chronic Bile Duct Obstruction on Renal Handling of Salt and Water

Better¹,

Massry²

1972

J. Clin. Invest.

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A B S T R A C T Renal sodium reabsorption and the concentrating and diluting abilities of the kidney were evaluated in the same trained mongrel dogs before and after chronic common bile duct ligation (BDL). Glomerular filtration rate (GFR) and CPAH were not altered by BDL. The natriuretic response to a standardized infusion of 0.45% solution of NaCl was markedly blunted by BDL (P < 0.01); calculated distal sodium delivery was significantly less in experiments after BDL than in control studies. Furthermore, the fractional reabsorption of sodium at the diluting segment for any given rate of distal delivery was enhanced by BDL. Similarly, CH2o/ 100 ml GFR for a given sodium delivery was higher after BDL than control values. Maximal urinary concentration (Uosm-max) was lower after BDL, and the mean Uosm-max for the whole group of animals was 60% of the control value (P<0.001). Mean maximal TCH-o/100 ml GFR after BDL was not different from control values; however, TCH2o/100 ml GFR for a given Cosm/100 ml GFR was lower after BDL in three dogs only. The sodium content of the inner part of renal medulla after BDL was significantly lower than the values obtained in control animals. The excretion of an oral water load in the conscious state was impaired after BDL; although all animals excreted hypotonic urine, urinary osmolality was usually higher after BDL than in control studies. Maximal urinary concentration and the excretion of an oral water load were not affected by sham operation.These studies demonstrate that chronic, common bile duct ligation is associated with (a) enhanced sodium Dr.

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Renal failure in patients with cirrhosis of the liver

Cited by 85 publications

References 31 publications

The spectrum of renal changes in patients with liver diseases: an immunofluorescent and light microscopic study

The spectrum of renal changes in patients with liver diseases: an immunofluorescent and light microscopic study

Systemic and Renal Hemodynamics in Oliguric Hepatic Failure: Effect of Volume Expansion*

Effect of Chronic Bile Duct Obstruction on Renal Handling of Salt and Water

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