Renal function and hyperfiltration capacity in lead smelter workers with high bone lead.

Abstract

Objective-The study was undertaken to assess whether the changes in urinary excretion of eicosanoids (a decrease of 6-keto-PGF,, and PGF, and an increase of thromboxane) previously found in lead (Pb) exposed workers may decrease the renal haemodynamic response to an acute oral protein load. Methods-The renal haemodynamic response was estimated by determining the capacity of the kidney to increase the glomerular filtration rate (in terms of creatinine clearance) after an acute consumption of cooked red meat (400 g). A cross sectional study was carried out in 76 male Pb workers (age range 30 to 60 years) and 68 controls matched for age, sex, socioeconomic state, general environment (residence), and workshift characteristics.

Characterizing Golden Eagle Risk to Lead and Anticoagulant Rodenticide Exposure: A Review

“…Lead levels in trabecular bone (in adults) correlate more highly with contemporary PbB than do levels of lead in cortical bone (Erkkila et al 1992;Hernandez-Avila et al 1996;Hu et al 1996bHu et al , 1998Watanabe et al 1994). Cortical bone lead measurements correlate well with time-integrated PbB measurements, which would be expected to be a better reflection of cumulative exposure than contemporary blood lead measurements (Borjesson et al 1997;Roels et al 1994). Bone lead levels tend to increase with age Kosnett et al 1994;Roy et al 1997), although the relationship between age and bone lead may be stronger after adolescence (Hoppin et al 1997).…”

“…Lead exposure has also been associated with increases in glomerular filtration rate (Hsiao et al 2001;Hu 1991b;Roels et al 1994). This may represent a benign outcome or a potentially adverse hyperfiltration, which may contribute to subsequent adverse renal effects.…”

Associations of Patella Lead and Other Lead Biomarkers With Renal Function in Lead Workers

“…In contrast, an association between higher tibia lead and higher 2-hour measured creatinine clearance was found in a combined group of 76 lead workers and 68 controls (mean blood lead ϭ 14.1 g/dL in the control group). 17 No significant associations between tibia lead and the other renal outcomes studied, including serum creatinine, NAG, and RBP, were observed. Blood lead was not associated with any of the renal outcomes.…”

“…The mean age of workers in our oldest tertile was 54.1 years and the mean age of the Normative Aging population was 67.0 years. 16 Thus, the inverse association between higher tibia lead and creatinine clearance noted by Roels and colleagues 17 was in a relatively younger population compared with the participants in our oldest tertile and in the Normative Aging Study in whom associations between higher lead measures and worse renal function were observed. Analyses of data from the first evaluation of this Ko- *The renal outcomes were each modeled separately, with one of the four lead measures included at a time (resulting in a total of 24 models).…”

“…This pattern of progression has been observed in rats with high lead exposure, 19 although less so with lower lead exposure. 20 The mean ages of the lead workers in the studies cited above were 43.6 17 and 37.4 years, 18 respectively. The mean age of workers in our oldest tertile was 54.1 years and the mean age of the Normative Aging population was 67.0 years.…”