Renal function in Ankylosing Spondylitis

Saigal, Renu; Agrawal, Arun K.; Goyal, Laxmikant; Agrawal, Abhishek; Gupta, Naveen

doi:10.4103/injr.injr_93_16

Cited by 4 publications

(3 citation statements)

References 1 publication

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“…However, this study was insu cient to explain the safety of kidney function in patients with AS requiring long-term treatment with NSAIDs. One age-and sex-matched study of AS reported that the group that used NSAIDs for more than 48 months had a lower rate of kidney dysfunction than those who took NSAIDs for less than 48 months [24]. The authors suggested that these results may be due to AS itself and not to NSAIDs induced nephropathy.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Long-term use of Nonsteroidal Anti-inflammatory Drugs and Kidney Function in Patients with Ankylosing Spondylitis

Koo

Hwang

Park

et al. 2023

Preprint

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Background Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for ankylosing spondylitis (AS), their effect on kidney function remains unclear. This longitudinal study investigated the correlation between long-term NSAID use and kidney function in patients with AS using electronic medical records. Methods The electronic medical records of 1,280 patients with AS collected from a single center between January 2001 and December 2018 were reviewed. The Assessment of Spondyloarthritis International Society (ASAS) NSAID Intake Score was used to determine the cumulative dose of all NSAIDs prescribed for a different time intervals. Each ASAS NSAID Intake Score was obtained for intervals of 6 months, 1 year, 2 years, 3 years, 5 years, and 10 years. The correlation between the ASAS NSAID Intake Score and final estimated glomerular filtration rate (eGFR) for each interval was investigated. Results The mean ASAS Intake Scores for 6-month, 1-year, 2-year, 3-year, 5-year, and 10-year intervals were 55.30, 49.28, 44.84, 44.14, 44.61, and 41.17, respectively. At each interval, the pearson correlation coefficients were − 0.018 (95% CI: -0.031 ‒ -0.006, p = 0.004), -0.021 (95% CI: -0.039 ‒ -0.004, p = 0.018), -0.045 (95% CI: -0.071 ‒ -0.019, p = 0.001), -0.069 (95% CI: -0.102 ‒ -0.037, p < 0.001), -0.070 (95% CI: -0.114 ‒ -0.026, p = 0.002), -0.019 (95% CI: -0.099 ‒ 0.062, p = 0.645), respectively. There was a very weak negative relationship between ASAS Intake Score and eGFR at each interval. Conclusion Long-term NSAID use did not correlate with kidney function based on real-world data in patients with AS.

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Section: Discussionmentioning

confidence: 99%

The Relationship between Long-term use of Nonsteroidal Anti-inflammatory Drugs and Kidney Function in Patients with Ankylosing Spondylitis

Koo

Hwang

Park

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…However, this study was insufficient to explain the safety of kidney function in patients with AS requiring longterm treatment with NSAIDs. One age-and sex-matched study of AS reported that the group that used NSAIDs for more than 48 months had a lower rate of kidney dysfunction than those who took NSAIDs for less than 48 months [24]. The authors suggested that these results may be due to AS itself and not to NSAIDs induced nephropathy.…”

Section: Discussionmentioning

confidence: 99%

The relationship between long-term use of nonsteroidal anti-inflammatory drugs and kidney function in patients with ankylosing spondylitis

et al. 2023

View full text Add to dashboard Cite

Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for ankylosing spondylitis (AS), their effect on kidney function remains unclear. This longitudinal study investigated the correlation between long-term NSAID use and kidney function in patients with AS using electronic medical records. Methods: The electronic medical records of 1,280 patients with AS collected from a single center between January 2001 and December 2018 were reviewed. The Assessment of Spondyloarthritis International Society (ASAS) NSAID Intake Score was used to determine the cumulative dose of all NSAIDs prescribed for a different time intervals. Each ASAS NSAID Intake Score was obtained for intervals of 6 months, 1 year, 2 years, 3 years, 5 years, and 10 years. The correlation between the ASAS NSAID Intake Score and final estimated glomerular filtration rate (eGFR) for each interval was investigated.

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“…In a Chinese retrospective study, Wu, et al defined decreased renal function as an eGFR level lower than 60 ml/min/1.73 m 2 with a prevalence of 0.1% (Wu et al, 2018). In contrast, an eGFR level lower than 90 ml/min/1.73 m 2 was regarded as a reduced eGFR in a hospital-based Indian study, and the prevalence, 37.5%, was much higher (Saigal et al, 2017). The lower prevalence of a decreased eGFR (0.3%) in our study might be due to the relatively strict definition used.…”

Section: Discussionmentioning

confidence: 99%

Spondyloarthritis Patients Suffer Increased Risk of Renal Complications Compared With General Population: A Retrospective Observational Study

Xiao

et al. 2019

Front. Pharmacol.

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The objective of this study was to identify the prevalence and risk factors of renal complications of spondyloarthritis (SpA) patients, and to assess increased risks compared to general people. We conducted a retrospective study enrolled with consecutive SpA patients from an inpatient department and age, sex-matched general population (GP). The renal disorders investigated in this study contained decreased estimated glomerular filtration rate (eGFR), hematuria, proteinuria and nephrolithiasis. A total of 350 admitted SpA patients with complete medical records and 323 age and sex-matched GP were enrolled. Most SpA patients were male (n = 283, 80.9%) and the mean age was 31.61 ± 10.73 years old. Among 350 SpA patients, 29 (8.8%) suffered from hematuria, six (1.8%) suffered from proteinuria, one (0.3%) had decreased eGFR, and 27 (13.0%) presented with nephrolithiasis. The relative risk (RR) of nephrolithiasis in SpA compared to the GP was 2.24 (95% CI, 1.00-4.98), and the RR of renal insufficiency was 2.04 (95% CI, 1.11-3.77). In a univariate analysis, nephrolithiasis was significantly associated with age, age of onset, smoking, extra-articular manifestation and a bamboo spine. Renal insufficiency was significantly associated with age, peripheral manifestation, serum albumin, C-reactive protein and erythrocyte sedimentation rate. In a multivariable analysis, only extra-articular manifestation (OR = 8.43, 95% CI, 1.65-43.06, p = 0.010) and bamboo spine (OR = 3.47, 95% CI, 1.01-12.06, p = 0.049) remained significantly associated with nephrolithiasis. However, no variable was recognized as an independent risk factor for renal insufficiency. Renal complications are more common in SpA patients, with more than two-fold increased risk compared with GP. Extra-articular manifestation and bamboo spine are independent risk factors of renal disease in SpA patients.

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Renal function in Ankylosing Spondylitis

Cited by 4 publications

References 1 publication

The Relationship between Long-term use of Nonsteroidal Anti-inflammatory Drugs and Kidney Function in Patients with Ankylosing Spondylitis

The Relationship between Long-term use of Nonsteroidal Anti-inflammatory Drugs and Kidney Function in Patients with Ankylosing Spondylitis

The relationship between long-term use of nonsteroidal anti-inflammatory drugs and kidney function in patients with ankylosing spondylitis

Spondyloarthritis Patients Suffer Increased Risk of Renal Complications Compared With General Population: A Retrospective Observational Study

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