Renal function in high-altitude natives and in natives with chronic mountain sickness

Lozano, R.; Monge, Carlos

doi:10.1152/jappl.1965.20.5.1026

Cited by 29 publications

(19 citation statements)

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“…This study confirms previous results showing that renal hemo dynamics at high altitude is different from that at sea level [2,9]. The glomerular filtration rate is slightly reduced, the effective renal plasma flow is markedly depressed, and therefore, the filtration fraction is increased.…”

Section: Discussionsupporting

confidence: 91%

Effect of Angiotensin on the Kidney of the High Altitude Native

Torres¹,

Lozano²,

Whittembury³

et al. 1970

Nephron

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Renal hemodynamics, sodium and water excretion were studied in six sea level residents and eight high altitude (4,500 m) natives before, during and after the infusion of small amounts of angiotensin (0.32 µg/min). In basal conditions the high altitude group showed a mild reduction in the glomerular filtration rate, with a higher reduction in the renal plasma flow and a normal or slightly increased renal blood flow. During angiotensin infusion, both sea level and high altitude groups responded with a marked reduction in urine flow and sodium excretion. The glomerular filtration rate and renal plasma flow diminished with a greater fall in the latter. This changes were slighter in the high altitude group, except in the sodium to inulin clearance ratio, which was similar in both groups. Despite a high filtration fraction, the kidney of the high altitude native responds to angiotensin like the sea level kidney. These results are discussed in relation to the paradoxical renal response to angiotensin observed in the hypertensive patient.

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Section: Discussionsupporting

confidence: 91%

Effect of Angiotensin on the Kidney of the High Altitude Native

Torres¹,

Lozano²,

Whittembury³

et al. 1970

Nephron

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“…Despite a reduction in RPF, GFR is maintained and fi ltration fraction (GFR/RPF) rises proportionally to the RPF drop; renal O 2 delivery, a-v O 2 content gradients, and renal O 2 consumption are equal to sea level residents [ 16 ]. However, with greater hypoxia, RBF ultimately falls by about 30 % in healthy subjects newly residing at 6,000 m [ 17 ] and by roughly the same magnitude in chronic mountain sickness [ 18 ].…”

Section: Renal Hemodynamicsmentioning

confidence: 99%

Renal Function and Fluid Homeostasis

Swenson

Olsen

2013

High Altitude

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Hypoxia can directly affect the kidneys, but more importantly, its effects on systemic acid-base balance, ventilation, neuroendocrine refl exes, and hemodynamics all play a far greater part in altering renal function and fl uid balance. Acute and chronic effects of hypoxia and their magnitude may differ and these will be highlighted. These changes will be related to the common diseases of high altitude and to their impact on patients with chronic renal disease. Other features of high altitude separate from hypoxia, either alone or in combination, including hypobaria, exercise, and cold may also signifi cantly perturb renal function.

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“…Because the filtration fraction increases by 39%, however, GFR falls by only 12%. 14,15 In addition, whole organ oxygen delivery, arteriovenous content gradients, and consumption are also maintained at levels equal to sea-level values. 16 Similar findings are present in chronically hypoxic rats.…”

Section: Normal Kidney Physiology At High Altitudementioning

confidence: 99%