Renal function in Sudanese school children withSchistosoma mansoni infection

Abstract

Renal function was investigated in 218 school children with Schistosoma mansoni infection in the Providence of Gezira in central Sudan and in 65 Sudanese and 65 German age-matched controls. Serum creatinine was normal in all children. A pathological urinary protein-creatinine ratio was found in 3% of S. mansoni-infected children and in 5% of Sudanese controls but in none of the European children. Characterization of pathological proteinuria using albumin nephelometry, alpha-1 microglobulin immunodiffusion and SDS-polyacrylamide gel electrophoresis in these children showed glomerular, tubular or mixed glomerulotubular patterns. One, 4 and 6 months following treatment of schistosomiasis with praziquantel, stools were re-examined; 57% of patients were cured, 16% were found to be reinfected and 27% had persistent egg excretion. Six months after therapy, pathological urinary protein-creatinine ratios were encountered in 3% of S. mansoni patients and in none of the 34 reinvestigated controls. Proteinuria was similar in patients with persistent S. mansoni egg excretion and in children cured of schistosomiasis infection. It is concluded that there was no evidence for S. mansoni associated glomerulonephritis in this group of Sudanese children. The high rate of pathological proteinuria in S. mansoni-infected and non-infected Sudanese children may be due to other causes.

The Influence of HIV and Schistosomiasis on Renal Function: A Cross-sectional Study among Children at a Hospital in Tanzania

“…The prevalence of proteinuria among adult subjects infected with S. mansoni has been reported to be as high as 20% in Egypt [ 38 , 39 ] and 15% in Brazil [ 40 , 41 ], and the severity and irreversibility of the disease has been demonstrated in several clinicopathologic and experimental studies [ 42 – 44 ]. The association between markers of kidney disease and S. mansoni in children, by contrast, has only been investigated in two small studies in SSA [ 45 , 46 ] which did not find an association between S. mansoni and overt proteinuria, but neither one of them investigated both eGFR and albuminuria as we have done. If further studies confirm the relationship between S. mansoni infection and kidney disease among children, schistosomiasis may become an important target for prevention of kidney disease in our population.…”

Malaria-induced renal damage: facts and myths

“…The literature on NS in Sudan is scarce. Studies on renal function in 218 Sudanese school children and 58 adults failed to detect a significant number of patients with schistosomal glomerulopathy [96], and adults with advanced hepatosplenic schistosomiasis did not develop renal changes suggesting schistosomiasis induced GN [97]. Concerning East Africa, John Kibukamusoke and Michael Hutt were the pioneers of studying nephrotic syndrome in Uganda in the 1960s.…”

Profile of T and B lymphocytes in individuals resistant to Schistosoma mansoni infection

“…Classification of T lymphocytes as the expression of CD25 in TCD4 and TCD8 (E, F) and B lymphocytes as to the expression of CD5 (G). Histogram representative of the expression of molecules associated with the regulatory profile in TCD4 (H), TCD8 (I), and BCD19 (J) ◂ cause the development of glomerulopathies (Elsheikh et al 1989;Gryschek and Chieffi 2008). No laboratory evidence of severe forms of schistosomiasis disease was observed in this study.…”