Renal function trajectories in hepatitis C infection: differences between renal healthy and chronic kidney disease individuals

Abstract

Associations between hepatitis C virus (HCV) and chronic kidney disease (CKD) have been reported; however, differences of renal progression between general and CKD population remain to be elucidated in prospective studies. A total of 1179 participants, who have tested for anti-HCV antibody, were enrolled and prospectively followed for 3 years. The risks associated with HCV infection, in terms of incidence of CKD, annual estimated glomerular filtration rate (eGFR) changes and 50% decline of eGFR at 3-year from baseline, were compared between normal renal function subjects and CKD patients. Overall, 111 of 233 (47.6%) CKD patients and 167 of 946 (17.7%) non-CKD subjects had HCV infection. The crude incidence rates of CKD were 226.9 per 1000 person-years and 14.8 per 1000 person-years in in HCV and non-HCV infected patients, respectively. The adjusted hazard ratio of HCV infection for incident CKD was 7.9 (95% CI 5–12.7). The HCV-infected normal renal function subjects were independently associated with increased risks of eGFR decline in the 1-year, 2-year and 3-year, respectively. The risk associations remained significant in 50% decline of eGFR at 3 years models and in different subgroup analyses. The increases of risks of eGFR decline were also notorious among overall HCV-infected CKD patients. However, the risk associations were less prominent in subgroup analyses (elderly, women and diabetic patients). The findings highlighted the importance of viral diagnosis with not only prognostic but also public health implications for preserving kidney function.

Mitochondrial DNA copy number is associated with incident chronic kidney disease and proteinuria in the AIDS linked to the intravenous experience cohort

“…The higher drug burden on kidneys, as well as adverse drug-drug interactions 33 increase susceptibility for adverse kidney related outcomes compared to other PWH. A meta-analysis showed that sharing syringes and drug preparation materials is associated with a ~ 2 fold increase in risk of HCV seroconversion 34 , which can contribute to kidney function decline via accumulation of viral antigen–antibody complexes and viral effects 35 , 36 . This study also reported population attributable risk ranging between 25 and 43%, implying the percent by which HCV seroconversion can reduce upon elimination of these behaviors in the PWID population.…”

Pan-genotypic direct-acting antivirals for patients with hepatitis C virus infection and chronic kidney disease stage 4 or 5

“…Several global surveys have shown a higher prevalence rate of HCV infection among patients on hemodialysis than among patients on peritoneal dialysis [ 11 – 14 ]. Apart from the mechanistic relationship, many epidemiologic studies have confirmed a strong link between HCV and CKD [ 15 – 20 ].…”

Association of hepatitis C virus infection status and genotype with kidney disease risk: A population-based cross-sectional study

“…Hepatitis C virus (HCV) infection had been shown to associate with chronic kidney disease (CKD) [1]. When compared with HCV seronegative individuals, those with HCV seropositivity were more likely to have dipstick proteinuria and long-term risk of incident CKD [2,3]. Additionally, among United States (U.S.) veterans with baseline estimated glomerular filtration rate (eGFR) � 60 mL/min/1.73 m 2 , those with anti-HCV antibodies or detectable HCV ribonucleic acid (RNA) were associated with higher risk of incident CKD and rapid decline in eGFR as opposed to seronegative individuals [4].…”

“…Additionally, among United States (U.S.) veterans with baseline estimated glomerular filtration rate (eGFR) � 60 mL/min/1.73 m 2 , those with anti-HCV antibodies or detectable HCV ribonucleic acid (RNA) were associated with higher risk of incident CKD and rapid decline in eGFR as opposed to seronegative individuals [4]. Furthermore, CKD patients with HCV seropositivity or HCV viremia had higher risk of kidney disease progression when compared with individuals without HCV infection [3,5,6].…”