Renal functional reserve in patients with Type 1 diabetes mellitus

Zaletel, Jelka; Černe, Darko; Lenart, Katarina; Zitta, Sabine; Jürgens, Günther; Estelberger, Willibald; Kocijancic, A

doi:10.1007/bf03041055

Cited by 6 publications

(6 citation statements)

References 45 publications

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“…The mechanisms behind exercise-induced ADMA reduction cannot be directly determined from our results. It is not likely that changes in renal function, which is also related to endothelial function [32], account for the altered ADMA plasma levels, because creatinine levels remained in the normal range and did not change during the observation period. There is evidence that training may influence the antioxidant status through increased expression of the potent radical scavenger superoxide dismutase [33].…”

Section: Discussionmentioning

confidence: 84%

Regelmäßiges körperliches Training normalisiert erhöhte Konzentrationen von asymmetrischem Dimethylarginin bei Patienten mit Typ-1-Diabetes

Mittermayer

Pleiner

Krzyżanowska

et al. 2005

Wien Klin Wochenschr

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Section: Discussionmentioning

confidence: 84%

Regelmäßiges körperliches Training normalisiert erhöhte Konzentrationen von asymmetrischem Dimethylarginin bei Patienten mit Typ-1-Diabetes

Mittermayer

Pleiner

Krzyżanowska

et al. 2005

Wien Klin Wochenschr

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“…Both the decrease in NAG excretion and the increase in DIR, which roughly corresponds to the renal functional reserve, may also reflect the beneficial effect of sulodexide on the renal-vascular function by limiting the tubulo-interstitial compartment dysfunction [31]. However, some data suggest that the permanent decrease in the renal functional reserve can only be detected in diabetic patients whose baseline kidney function is still normal [32]. At present we have no data on DIR in the control group, and our conclusions are speculative.…”

Section: Discussionmentioning

confidence: 99%

Effect of Sulodexide on Albuminuria, NAG Excretion and Glomerular Filtration Response to Dopamine in Diabetic Patients

Sulikowska

Olejniczak²,

Muszyńska³

et al. 2006

Am J Nephrol

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Background: Albuminuria is the best and most readily available marker for glomerular damage and progressive renal function loss in patients with diabetic nephropathy. Recently, administration of the oral glycosaminoglycan sulodexide (a mixture of 80% fast-moving heparin and 20% dermatan sulphate) was shown to effectively decrease albumin excretion rate in diabetics with nephropathy. Aims: To evaluate whether the hypoalbuminuric effect of sulodexide is associated with improvement of the renal vascular or tubule function. Methods: Forty-five type 1 diabetic patients, affected by diabetic nephropathy with albuminuria for at least 5 years, were randomly allocated to sulodexide or untreated. Those allocated to sulodexide were given 100 mg of sulodexide daily for 120 days. Renal vascular function (DIR) and N-acetyl-β-D-glucosaminidase (NAG) excretion were estimated before and at the end of the study, the former in thesulodexide group only. DIR was measured as two Cr_cl lasting 120 min (before and during 2 µg/kg b.w. i.v. dopamine). Results: The analysis of trends during the study demonstrated a marked reduction of albuminuria in the sulodexide group (from 126.1 ± 15.41 to 93.6 ± 13.7 mg/day). DIR rose from 13.2 ± 2.1% to 15.44 ± 1.9% (relative increase: +16.9%), and NAG excretion showed a decreasing trend decreased in the sulodexide group only (from 5.1 ± 0.62 to 4.7 ± 0.40 U/g_creat). Conclusion: The findings presented in this study indicate for the first time that orally available sulodexide may favorably affect the renal vascular function in type 1 diabetic patients with nephropathy and microalbuminuria. The effect of sulodexide on NAG is strongly influenced by the baseline NAG values, with a significant NAG reduction in the patients with the highest baseline NAG values.

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“…It is not likely that changes in renal function, which is also related to endothelial function, account for the altered plasma ADMA levels, because inulin and creatinine clearances remained within the normal range in transplant patients and did not differ at the end of the observation period. There is evidence that training may affect the antioxidant status through increased expression of the potent radical scavenger superoxide dismutase [24,25,26]. …”

Section: Discussionmentioning

confidence: 99%

Early Exercise Training After Renal Transplantation and Asymmetric Dimethylarginine: The Effect of Obesity

Teplan

Mahrová²,

Piťha³

et al. 2014

Kidney Blood Press Res

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Background/Aims: To assess, in a prospective cohort study of 238 renal transplant patients, our hypothesis that elevated ADMA levels may be influenced by physical exercise and obesity. Methods: Blood samples before and after six months were obtained from 116 transplant patients participating in an aerobic exercise (Group I). A control group consisted of 122 matched transplant patients who did not exercise regularly (Group II). Results: There were no significant differences in ADMA levels between both groups before the training program (Group I_B vs Group II_B). After six months of exercise, ADMA levels in Group I decreased (Group I_B vs Group I_A : 3.50 ± 0.45 vs 2.11 ± 0.35μmol/L; p< 0.01) and were lower compared to those in Group II (Group I_A vs Group II_A : 2 11 ± 0 23 vs 3 25 ± 0 34μmol/L; p< 0 01) Analysis of our results in obese renal transplant recipients (BMI B 30 kg/m²) confirmed a smaller effect of exercise training (Group I_BO vs Group I_AO : 3 75 ± 0 52 vs 3 45 ± 0 45; p< 0 05 and Group I_AO vs Group II_AO : 3.45 ± 0.45 vs 3.74 ± 0.62; p<0.05). Blood lipids, HbA_1C, insulin, and systolic BP were also affected by the training program. Conclusion: Elevated ADMA levels were significantly decreased by early exercise after renal transplantation. The effect of exercise was smaller in obese patients.

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Renal functional reserve in patients with Type 1 diabetes mellitus

Cited by 6 publications

References 45 publications

Regelmäßiges körperliches Training normalisiert erhöhte Konzentrationen von asymmetrischem Dimethylarginin bei Patienten mit Typ-1-Diabetes

Regelmäßiges körperliches Training normalisiert erhöhte Konzentrationen von asymmetrischem Dimethylarginin bei Patienten mit Typ-1-Diabetes

Effect of Sulodexide on Albuminuria, NAG Excretion and Glomerular Filtration Response to Dopamine in Diabetic Patients

Early Exercise Training After Renal Transplantation and Asymmetric Dimethylarginine: The Effect of Obesity

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