Atherosclerosis

2017

DOI: 10.1016/j.atherosclerosis.2017.02.015

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Renal glucosuria is not associated with atherosclerotic cardiovascular disease outcome in a general Japanese community

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Masa‐aki Kawashiri

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et al.

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Cited by 9 publications

(7 citation statements)

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“…10,11 For proper diagnosis of familial renal glycosuria; diabetes mellitus, Fanconi syndrome (amino aciduria, phosphaturia, bicarbonaturia, cystinuria, proteinuria), pregnancy, drug history and acute tubular necrosis should be searched in differential diagnosis. 9 In our case, diagnostic work out revealed isolated renal glycosuria in the absence of other abnormalities listed above. With this case we aim to remind clinicians a very rare cause of glycosuria.…”

Section: Discussionsupporting

confidence: 46%

“…Renal glycosuria was also reported not to be associated with atherosclerotic cardiovascular diseases. 9 However, episodic dehydration and ketosis during pregnancy and starvation, polyuria, enuresis and an increased incidence of urinary tract infections were reported with this situation in the literature. 10,11 For proper diagnosis of familial renal glycosuria; diabetes mellitus, Fanconi syndrome (amino aciduria, phosphaturia, bicarbonaturia, cystinuria, proteinuria), pregnancy, drug history and acute tubular necrosis should be searched in differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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A Case with Renal Glycosuria

et al. 2018

Turkiye Klinikleri J Case Rep

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nder normal conditions, kidneys assist glucose homeostasis by synthesizing glucose via gluconeogenesis and preventing urinary glucose loss via tubulary glucose reabsorption. 1 Reabsorption of glucose which is freely filtered in the glomeruli almost completely occur in proximal tubules only. This glucose reabsorption is mostly (90%) carried out by sodium-glucose cotransporters type 2 (SGLT-2) and glucose transporters 2 (GLUT2). So in patients with normal kidney function, significant glycosuria does not generally occur until the plasma glucose concentration exceeds 180 mg/dL (10 mmol/L). 2 Glycosuria may be due to either the inability of the kidney to reabsorb filtered glucose in the proximal tubule despite normal plasma glucose concentration, or to an overflow scenario related to high plasma glucose concentrations overwhelming the capacity of the renal tubules to reabsorb glucose. The commonest cause of glycosuria is uncontrolled diabetes mellitus. Abnormally elevated levels of glucose in the blood result in high amount of filtered glucose waiting to be reabsorbed through overactive SGLT2 which execute reabsorption eventually. When glycosuria occurs with a normal plasma glucose, a primary defect of proximal tubule reabsorption (renal glycosuria) needs to be considered. 1,2 Renal glycosuria is a rare and long

“…10,11 For proper diagnosis of familial renal glycosuria; diabetes mellitus, Fanconi syndrome (amino aciduria, phosphaturia, bicarbonaturia, cystinuria, proteinuria), pregnancy, drug history and acute tubular necrosis should be searched in differential diagnosis. 9 In our case, diagnostic work out revealed isolated renal glycosuria in the absence of other abnormalities listed above. With this case we aim to remind clinicians a very rare cause of glycosuria.…”

Section: Discussionsupporting

confidence: 46%

“…Renal glycosuria was also reported not to be associated with atherosclerotic cardiovascular diseases. 9 However, episodic dehydration and ketosis during pregnancy and starvation, polyuria, enuresis and an increased incidence of urinary tract infections were reported with this situation in the literature. 10,11 For proper diagnosis of familial renal glycosuria; diabetes mellitus, Fanconi syndrome (amino aciduria, phosphaturia, bicarbonaturia, cystinuria, proteinuria), pregnancy, drug history and acute tubular necrosis should be searched in differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

A Case with Renal Glycosuria

et al. 2018

Turkiye Klinikleri J Case Rep

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nder normal conditions, kidneys assist glucose homeostasis by synthesizing glucose via gluconeogenesis and preventing urinary glucose loss via tubulary glucose reabsorption. 1 Reabsorption of glucose which is freely filtered in the glomeruli almost completely occur in proximal tubules only. This glucose reabsorption is mostly (90%) carried out by sodium-glucose cotransporters type 2 (SGLT-2) and glucose transporters 2 (GLUT2). So in patients with normal kidney function, significant glycosuria does not generally occur until the plasma glucose concentration exceeds 180 mg/dL (10 mmol/L). 2 Glycosuria may be due to either the inability of the kidney to reabsorb filtered glucose in the proximal tubule despite normal plasma glucose concentration, or to an overflow scenario related to high plasma glucose concentrations overwhelming the capacity of the renal tubules to reabsorb glucose. The commonest cause of glycosuria is uncontrolled diabetes mellitus. Abnormally elevated levels of glucose in the blood result in high amount of filtered glucose waiting to be reabsorbed through overactive SGLT2 which execute reabsorption eventually. When glycosuria occurs with a normal plasma glucose, a primary defect of proximal tubule reabsorption (renal glycosuria) needs to be considered. 1,2 Renal glycosuria is a rare and long

“…All those data were collected and anonymized by the Kanazawa Medical Association. Details of this health checkups are described in elsewhere [ [9] , [10] , [11] ].…”

Section: Methodsmentioning

confidence: 99%

Prevalence, self-awareness, and LDL cholesterol levels among patients highly suspected as familial hypercholesterolemia in a Japanese community

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et al. 2020

Practical Laboratory Medicine

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Backgrounds The prevalence of familial hypercholesterolemia (FH) among Japanese populations is still unclear. In addition, no prior data exist regarding the self-awareness. Accordingly, we aimed to investigate the prevalence, self-awareness, and LDL-C of patients with highly suspected as FH using data obtained in a community-based medical checkups. Methods This study included 52,276 subjects (18,588 men, 35.6%) aged ≥40 years who underwent the Japanese specific health checkup in Kanazawa City during 2018. We assessed the self-awareness of dyslipidemia (and the age) as well as the prevalence of patients with highly suspected as FH whose naïve LDL-C levels were ≥250 mg/dl. Naïve LDL-C levels were estimated by the adjustment (LDL-C/0.7) for those on lipid-lowering medication. We divided subjects into 3 groups based on their naïve LDL cholesterol level (≥250 mg/dl, 140–249, and ≤139 mg/dl). Results We identified 262 (0.5%) individuals highly suspected as FH whose naïve LDL-C levels were ≥250 mg/dl. Most of them (234 among 262, 89%) were under lipid-lowering medication; however, the self-awareness as dyslipidemia was not quite high (200 among 262, 76%), and their mean LDL-C level under lipid-lowering medication was 203 ± 35 mg/dl. Interestingly, the age of acknowledgement of dyslipidemia among the patients with highly suspected as FH was significantly younger than those in other categories (58 vs. 60/62 yrs, respectively, p < 0.05 for both). Conclusions The prevalence of patients highly suspected as FH was around 1 in 200, and their self-awareness as well as control were not still good enough among Japanese general populations.

“…Details of the National Japanese-specific health checkups were reported previously. [14][15][16] Briefly, the national healthcare campaign was launched by the Japanese government in 2008 to strategically focus on early screening, diagnosis, and treatment of the metabolic syndrome. All unemployed or retired residents in Japan aged 40 years or older are eligible for these health checkups, which are not mandatory, and individuals can voluntarily choose whether or not to participate.…”

Section: Study Populationmentioning

confidence: 99%

Association of Lower Urinary Tract Symptoms Based on the International Prostate Symptom Score and Cardiovascular Disease

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et al. 2021

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Background: Because it is unclear whether lower urinary tract symptoms (LUTS) are associated with cardiovascular disease (CVD) in the Japanese population, we explored the association in general Japanese men aged 55-75 years. Methods and Results:The cross-sectional study included male participants who had both national health checkup data and the International Prostate Symptom Score (IPSS) in the same calendar year between 2009 and 2017. LUTS severity was evaluated by IPSS. A robust Poisson regression model was used to assess the association between LUTS severity and the composite CVD outcome [coronary artery disease (CAD), stroke, or atrial fibrillation (AF)] and each component of the composite outcome. Prevalence ratio (PR) was adjusted for conventional cardiovascular risk factors. Of 16,781 male participants (mean age, 67±5 years), mild LUTS were observed in 9

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