Renal granular cell tumour (Abrikossoff tumour): case report and review of the literature

Abstract

A 52-year-old female was referred to our institute for an incidental renal mass. A homogenously enhancing mass was detected on multidetector CT (MDCT) imaging. Histologically, the tumour was consistent with granular cell tumour (GCT). GCT is a benign tumour that often involves the skin and subcutaneous tissue. Rarely has it been reported to involve the genitourinary system. Here we present the first reported case of GCT with renal involvement along with its MDCT imaging features. The authors also present a review of the literature along with a review of typical MDCT imaging features of enhancing renal masses with emphasis given to renal cell carcinoma and its varying subtypes.

Granular cell tumor of the breast: Molecular pathology and clinical management

“…In 3 cases, sentinel lymph node biopsy was also performed, and histopathology was negative for metastasis in all cases. Mean diameter at pathologic section was 11.4 mm (range: [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Tumor local relapse was reported in only one case (8.3%) and underwent second surgical excision, without any impact on long-term survival.…”

“…GCT is ubiquitous and can affect all soft tissues, in particular oral cavity . Much less frequently the gastrointestinal tract, tracheobronchial tree, skin, and other organs (parotids, thyroids, kidney, eye orbit) are affected …”

“…8 Much less frequently the gastrointestinal tract, tracheobronchial tree, skin, and other organs (parotids, thyroids, kidney, eye orbit) are affected. 9 Although GCT of the breast is a very rare condition, it appears as a misleading lesion, usually indistinguishable from the classic breast carcinoma. 10 Misdiagnosis of malignancy can lead to inappropriate radical treatment; the correct management of primary GCT of the breast is necessary because tumor recurrences have been reported in cases after 8 years.…”

Epidemiology of malignant cutaneous granular cell tumors: A US population-based cohort analysis using the Surveillance, Epidemiology, and End Results (SEER) database

“…Clinically, this finding is important in counseling patients on future risks and has implications for post-diagnosis screening and monitoring. Combined, less than ten renal 23 and pancreatic 24–30 granular cell tumors and have been reported in the literature. Though these cases may contribute to the increased incidence of renal and pancreatic cancers observed in patients with malignant cutaneous granular cell tumors, the biological underpinnings of any such relationship has not been explored.…”

Granular-cell tumor of the anterior abdominal wall

“…They can occur at almost any site, although most occur in the head and neck (with the tongue being the most commonly affected site [ 2 ]), and skin and subcutaneous tissues of the chest and upper extremities. There have also been case reports of GCTs arising in the breast ( 3 ), stomach ( 4 , 5 ), esophagus ( 6 ), pancreas ( 7 ), large bowel ( 1 , 8 , 9 , 10 , 11 ), thyroid ( 12 , 13 ), bronchus ( 14 ), abdominal wall ( 15 ), and kidney ( 16 ).…”