Renal Growth and Progression of Reflux Nephropathy in Children with Vesicoureteral Reflux

Shimada, Kenji; Matsui, Takayuki; Ogino, Toshihiro; Arima, Masaaki; Mori, Yoshinori; Ikoma, Fumihiko

doi:10.1016/s0022-5347(17)41970-7

Cited by 25 publications

(13 citation statements)

References 18 publications

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“…16.4% were defined as 'small', presenting an SDS of < -2.0. Nearly the same percentages (15.5-17%) of small kidneys associated with VUR were found in other studies by measurement of kidney length [19][20][21], Of the small kidneys, 59% showed renal scars. In these kidneys, diminished kidney size most likely was due to renal damage rather than primary dysplasia or hypoplasia.…”

Section: Discussionsupporting

confidence: 83%

“…However, it is difficult to draw any conclu sions about the pathogenesis of severe renal damage from radiological studies alone. Shimada et al [19] showed that in about half of the small kidneys the size was due to scarred atrophy and in 40% it was due to congenital hypoplasia. They admitted that it was not always easy to distinguish between these two entities.…”

Section: Discussionmentioning

confidence: 99%

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Long-Term Follow-Up of Children with Surgically Treated Vesicorenal Reflux: Renal Growth

Beetz

Hohenfellner²,

Schofer³

et al. 1991

Eur Urol

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Long-Term Follow-Up of Children with Surgically Treated Vesicorenal Reflux: Renal Growth

Beetz

Hohenfellner²,

Schofer³

et al. 1991

Eur Urol

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“…Shimada et al [7] have shown that affected kidneys could not catch up with normal kidneys after successful reimplant, but they can grow at a rate parallel to the expected growth curve. Hence, it is important to reimplant to prevent kidney damage or further damage.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Post-Ureteric Reimplantation Urinary Tract Infection in Primary Vesicoureteral Reflux

Mariyappa

Maruthayanar

Samnakay

et al. 2016

World J Nephrol Urol

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Background: The goal of treatment in vesicoureteral reflux (VUR) is to reduce the risk of reflux-associated pyelonephritis. Medical versus surgical treatment for VUR is still controversial, with surgery successful in majority of cases. There are not enough data available in literature on long-term incidence of urinary tract infection (UTI) after reimplantation. The aim of the study was to determine the long-term outcome after reimplantation with respect to UTI, renal scarring and potential risk factors for post-reimplant UTI.

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“…Follow up results for children with VUR have been discussed in many articles. New scar development was reported to be 3-30% 12,[19][20][21][22] in children with primary VUR and up to 86% 21,22 in children with secondary VUR. Compared to these previous data, our results showed quite a low rate of new scar development.…”

Section: Discussionmentioning

confidence: 99%

Reappraisal of Tc-99m DMSA scintigraphy for follow up in children with vesicoureteral reflux

et al. 1999

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We reviewed Tc-99m DMSA scintigraphy in children with vesicoureteral reflux (VUR) in order to assess whether repeated Tc-99m DMSA scans are necessary for the follow up of these patients. Ninety-seven children who were followed up for more than one year (1-7.4 years, average 2.8 years) after the first DMSA scan were included in the study. Fifty-one patients had been diagnosed as primary VUR and 46 as secondary VUR. Age at the first examination ranged from 0 to 14 years (average 5.1 years). Planar images were taken 2 hours after injection. The % renal uptake per injected dose (%RU) was calculated from posterior images. Kidneys in 11 patients (11.3%) changed morphologically during the follow up. Of these, new photon deficient areas (PD) were detected in only 4 patients (4.1%). All of these 4 patients had neurogenic bladder and were managed with self-catheterization. Of the remaining 7 patients, cortical thinning progressed in 5 patients (5.2%) and PDs resolved in 3 patients (3.1%). In one of these 7 patients, PD resolved in one kidney and cortical thinning progressed in the contralateral kidney. Of 97 patients reviewed, % RU decreased more than 20% during the follow up in 6 patients (6.2%). All were diagnosed as secondary VUR due to neurogenic bladder. %RU decreased only in the contracted kidneys at the initial scan. Two of them underwent renal transplantation because of severe renal failure. In conclusion, new PD rarely developed and % RU decreased in only a few patients during the follow up of children with VUR. Repeated Tc-99m DMSA scintigraphy therefore seems to have little benefit in the follow up of children with VUR. It should be performed in selected patients with high risk of urinary tract infection or renal failure.

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Renal Growth and Progression of Reflux Nephropathy in Children with Vesicoureteral Reflux

Cited by 25 publications

References 18 publications

Long-Term Follow-Up of Children with Surgically Treated Vesicorenal Reflux: Renal Growth

Long-Term Follow-Up of Children with Surgically Treated Vesicorenal Reflux: Renal Growth

Incidence of Post-Ureteric Reimplantation Urinary Tract Infection in Primary Vesicoureteral Reflux

Reappraisal of Tc-99m DMSA scintigraphy for follow up in children with vesicoureteral reflux

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