Renal handling of nitrate in women and men with elevated blood pressure

Sundqvist, Michaela L.; Lundberg, Jon O.; Weitzberg, Eddie; Carlström, Mattias

doi:10.1111/apha.13637

Cited by 10 publications

(11 citation statements)

References 44 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with HV, acute intake of nitrate was associated with significantly higher maximal plasma concentrations for nitrate and nitrite in HD patients as well as higher AUCs of these anions. Circulating nitrate (and nitrite) is mainly eliminated via the kidneys [41,42]. Therefore, the increased plasma concentrations of these two anions observed in our HD patients is most likely due to their full loss of residual renal function.…”

Section: Discussionmentioning

confidence: 82%

Plasma Nitrate and Nitrite Kinetics after Single Intake of Beetroot Juice in Adult Patients on Chronic Hemodialysis and in Healthy Volunteers: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study

et al. 2022

Self Cite

View full text Add to dashboard Cite

Nitric oxide (NO) contributes to maintaining normal cardiovascular and renal function. NO is generally formed enzymatically by NO synthase in the vascular endothelium. NO bioactivity can also be attributed to dietary intake of inorganic nitrate, which is abundant in our diet, especially in green leafy vegetables and beets. Ingested nitrate is reduced to nitrite by oral commensal bacteria and further to NO systemically. Previous studies have shown that dialysis, by means of removing nitrate and nitrite from the body, can reduce NO bioactivity. Hence, dietary intervention approaches aimed to boost the nitrate–nitrite–NO pathway may be of benefit in dialysis patients. The purpose of this study was to examine the kinetics of plasma nitrate and nitrite after a single intake of nitrate-rich concentrated beetroot juice (BJ) in adult hemodialysis (HD) patients and in healthy volunteers (HV). Eight HD patients and seven HV participated in this single center, randomized, single-blind, placebo-controlled, crossover study. Each participant received a sequential single administration of active BJ (70 mL 400 mg nitrate) and placebo BJ (70 mL 0 mg nitrate) in a random order separated by a washout period of seven days. For the kinetic analysis, blood samples were collected at different time-points before and up to 44 h after BJ intake. Compared with placebo, active BJ significantly increased plasma nitrate and nitrite levels both in HD patients and HV. The area under the curve and the maximal concentration of plasma nitrate, but not of nitrite, were significantly higher in HD patients as compared with HV. In both groups, active BJ ingestion did not affect blood pressure or plasma potassium levels. Both BJs were well tolerated in all participants with no adverse events reported. Our data provide useful information in planning dietary nitrate supplementation efficacy studies in patients with reduced NO bioactivity.

show abstract

Section: Discussionmentioning

confidence: 82%

Plasma Nitrate and Nitrite Kinetics after Single Intake of Beetroot Juice in Adult Patients on Chronic Hemodialysis and in Healthy Volunteers: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Co-administration of L-NAME and L-Arg showed no inflammatory effects, which may be due to the inhibitory effect of L-NAME on NO production from L-Arg so it can be concluded that L-NAME and similar compounds can be used to reduce NO-induced tissue damage. This feature has been used in various studies to reduce the pathological complications of NO [9].…”

Section: Discussionmentioning

confidence: 99%

Morphological evaluation of rat cerebellum following administration of nitrogen monoxide precursor and inhibitor

Chegini

Gholamzad

et al. 2022

Preprint

View full text Add to dashboard Cite

In this study, the quantitative and qualitative effects of nitrogen monoxide on cerebellar histo-pathology, by increasing or decreasing in vivo production of this substance, were investigated. In this study, forty Wistar female rats (RAT) with a weight of about 200 to 250 grams and an av-erage age of eight weeks were used. Rats were divided into five groups of eight, including control groups, normal saline, L-NAME, L-Arginine, L-NAME + L-Arginine. On the third, fourth and fifth days, the injection was performed intraperitoneally and on the eighteenth day, after anesthesia with ether and then craniotomy, the brain and cerebellum of the animals were removed and After quantitative measurements including weight and volume, organs were fixed in 10% formalin and after tissue preparation steps, to prepare the slide, sections with a thickness of 5 to 6 microns were prepared from the samples and by general method such as Hematoxylin-eosin and special techniques like Mason trichrome and toluidine blue were stained and evaluated. The results of this study show that in the case of cerebellum, there is no significant difference in the quantitative weight parameter between the control groups, normal saline, L-Arg, L-NAME and L-NAME + L-Arg groups. Regarding the volume parameter, a significant increase (P <0.01) was observed in L-Arg group compared to L-NAME, L-Arg + L-NAME and normal saline groups. In microscopic qualitative parameters, the most changes in the L-Arg group were seen as follows: The granular and molecular layers of the cerebellum became slightly thickened, some of the nuclei in the granular and molecular layers became severely hyperchromatized, and Purkinje cell accumulation was seen with lymphocytic invasion. In the other groups, there were no significant changes. It is inferred from this study that L-Arginine can cause histopathological changes in cerebellar tissue by increasing NO levels in cerebellum. However, in this study, unlike other similar studies, L-NAME injection did not cause significant histopathological change.

show abstract

“…It was concluded that there is evidence for a substantial nitrate sparing capacity of the kidneys, which is higher in women compared to men. 1 The study did not give any explanation about the underlying mechanisms which need to be resolved in future work.…”

mentioning

confidence: 87%

“…Nitric oxide (NO) is still regarded to be an important signaling molecule in blood pressure regulation and many aspects of its regulation are still unknown. The inorganic anions nitrate and nitrite are oxidation products of NO that have often been used as an index of NO generation 1 . The aim of a study by Sundqvist et al, was to explore potential sex differences in renal nitrate handling during low and high dietary nitrate intake.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in kidney research

Mrowka

2022

Acta Physiologica

View full text Add to dashboard Cite

Renal handling of nitrate in women and men with elevated blood pressure

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 10 publications

References 44 publications

Plasma Nitrate and Nitrite Kinetics after Single Intake of Beetroot Juice in Adult Patients on Chronic Hemodialysis and in Healthy Volunteers: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study

Plasma Nitrate and Nitrite Kinetics after Single Intake of Beetroot Juice in Adult Patients on Chronic Hemodialysis and in Healthy Volunteers: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study

Morphological evaluation of rat cerebellum following administration of nitrogen monoxide precursor and inhibitor

Recent advances in kidney research

Contact Info

Product

Resources

About