Renal hemodynamics in uranyl acetate-induced acute renal failure of rabbits

Sudo, Mutsuo; Nishio, Hisahide; Hishida, Akira; Nagase, Mitsumasa

doi:10.1038/ki.1977.5

Cited by 26 publications

(8 citation statements)

References 24 publications

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“…[18] have failed to prevent the fall in glomerular filtration and the ultimate development of severe functional dis turbances in the dog, despite well-maintained renal blood flow during the initial stage of nephrotoxic renal failure. Also, Hsu et al [16] demonstrated that the renal cortical blood flow of rats with myohemoglobinuric renal failure is essentially normal, and well-maintained renal blood flow has been found in other renal failure models [4,7,10,22,25]. The previous studies [20,25] from this laboratory suggested a minor role of renal hemodynamic alterations in the maintenance of oliguria in rabbits with acute renal failure, caused by either brief renal artery clamping or the intravenous injection of uranyl acetate.…”

Section: Introductionmentioning

confidence: 88%

“…Each cortical tissue slice was weighed and its radio activity was counted in a well scintillation counter. More than 96% of (he microspheres which entered the kidney were trapped in glom erular capillaries, with the remainder in the medulla and renal venous blood [25], The study of McNay and Abe [19] suggests that axial migration of microspheres docs not occur in the interlobular arteries. Therefore, the quantity of the nuclides per unit tissue weight in each cortical zone is a function of regional glomerular capillary flow.…”

Section: Clearance and Hemodynamic Studiesmentioning

confidence: 99%

“…Oliguric and nonoliguric acute renal failures were induced by the intravenous injections of2.0and 0.9 mg/kg body weight of uranyl acetate, respectively. Since renal functional disturbance and morphological damage were most remarkable 5 days after the injec tion [25], renal hemodynamic and clearance studies, histological examinations and retrograde ureteral '^C-inulin infusion experiments were performed at that time, and renal failure animals and normal controls were compared. Also, renal hemodynamic and inulin clear ance studies were made at the initial stage of oliguric renal failure, to examine the correlation of glomerular filtration change to renal hemodynamic alterations.…”

Section: Methodsmentioning

confidence: 99%

“…Regional blood flow in the different areas of the renal cortex was estimated by the s5Sr-labelled microsphere technique described by Me Nay and Abe [19], as previously reported [25]. A bolus of approxi mately 20 jjtCi of the microspheres (3M Co.. St Paul.…”

Section: Clearance and Hemodynamic Studiesmentioning

confidence: 99%

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Renal Hemodynamics in Oliguric and Nonoliguric Acute Renal Failure of Rabbits

Sudo¹,

Honda²,

Hishida³

et al. 1980

Nephron

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The role of renal hemodynamic alterations in the curtailment of renal functions was studied in uranyl acetate-induced oliguric (ORF) and nonoliguric (NORF) renal failures of rabbits. 5 days after drug injection, renal functional and morphological changes were most remarkable. A depression of C_in and elevation of serum creatinine concentration were more marked in ORF than in NORF. Renal blood flow was high as compared to controls. Cortical blood flow redistributed to the inner cortex. There was no significant difference in renal blood flow or cortical flow distribution between renal failure models. The findings suggest the minor roles of renal blood flow and cortical flow distribution in maintaining renal failure in these nephrotoxic models. Prominent tubular necrosis was found in ORF but not in NORF. Arterial inulin concentration during retrograde ureteral infusion of ¹⁴C-inulin solution was significantly high in ORF as compared to controls and NORF. However, this inulin leakage was too small to explain severely curtailed inulin clearance.

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Section: Introductionmentioning

confidence: 88%

Section: Clearance and Hemodynamic Studiesmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Clearance and Hemodynamic Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Renal Hemodynamics in Oliguric and Nonoliguric Acute Renal Failure of Rabbits

Sudo¹,

Honda²,

Hishida³

et al. 1980

Nephron

Self Cite

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“…We used the nephrotoxic agent uranyl nitrate (UN) [39, 40, 41, 42, 43]as a second variant for inducing renal damage. UN caused a specific damage of proximal tubular cells and the deposition of extracellular matrix (ECM).…”

Section: Introductionmentioning

confidence: 99%

Fibronectin Splice Variants – Prognostic Markers for the Stage of Renal Interstitial Fibrosis in the Rat

Eismann¹,

Sommer²,

Kosmehl

et al. 2002

Nephron

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Background/Aims: Renal interstitial fibrosis (RIF) is the main cause for progressive renal failure, but its pathogenic factors are not well known. In animal models of renal fibrogenesisdone thus far an increase of total fibronectin (FN) mRNA has been proved. Recent studies have pointed to a key role of the splice variant EIIIA⁺-FN and EIIIB⁺-FN for the development of organ fibrosis. However, a broader knowledge of the distribution of these different FN mRNA isoforms is still lacking. Our aim was to study the particular expression of the EIIIA⁺-FN and EIIIB⁺-FN during the process of fibrogenesis in two rat models and to evaluate the FN isoforms as diagnostic/prognostic marker for the stage of interstitial damage in rat kidneys. Methods: Kidneys of unilateral ureteral obstruction (UUO) and control rats were removed in intervals of 5, 14 or 21 days after surgery. For the investigation of kidney damage due to uranyl nitrate (UN), rats obtained a single i.p. dose of 5 mg/kg body weight UN and were killed 2, 10 and 20 weeks thereafter. The quantitative RT-PCR method was used to estimate the total FN, EIIIA⁺-FN and EIIIB⁺-FN transcription rate. Results: In the UUO model, a significant augmentation of both isoforms was obtained in the kidneys in the first 5-day interval, which was more pronounced at the 21-day interval. In the UN-treated kidneys there appeared only a continuous increase of EIIIA⁺-FN and the splice variant EIIIB⁺-FN failed to show a shift in these animals as compared to the controls. Conclusion: Both animal models generated fibrogenic damages of the tubulointerstitium, whereas only the UUO resulted in progressive fibrosis. Absence of EIIIB⁺-FN seems to enhance the progression of fibrogenesis.

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Renal Blood Flow

Hura

Stein

1992

Comprehensive Physiology

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The sections in this article are: Measurement of Renal Blood Flow Total Renal Blood Flow Regional Cortical Blood Flow Medullary Blood Flow Renal Microcirculation Control of Renal Circulation Intrinsic Factors Extrinsic Control Renovascular Resistance Changes in Selected Pathophysiological States Extracellular Volume Expansion Hemorrhagic Hypotension Acute Renal Failure

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Renal hemodynamics in uranyl acetate-induced acute renal failure of rabbits

Cited by 26 publications

References 24 publications

Renal Hemodynamics in Oliguric and Nonoliguric Acute Renal Failure of Rabbits

Renal Hemodynamics in Oliguric and Nonoliguric Acute Renal Failure of Rabbits

Fibronectin Splice Variants – Prognostic Markers for the Stage of Renal Interstitial Fibrosis in the Rat

Renal Blood Flow

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