Renal hemosiderosis

Reoperation after mitral valve repair in viewpoints of kidney injury as well as hemolytic anemia

“…In our case, elevated NAG and b2m levels indicate proximal tubular cell injury, and CT revealed that the hyperdensity of the renal cortex, liver, and spleen increased more than that before hemolysis. Magnetic resonance imaging (MRI) shows hypointensity of the renal cortex that is consistent with iron deposition due to MV repair compared with the renal medulla on both T1 and T2-weighted images [26], and hypointensity on both T1 and T2-weighted MR images and hyperdensity on CT images of liver are indicative of iron overload [27]. Thus, this finding of CT suggests continuous iron deposition in the renal cortex, liver, and spleen throughout the (Fig.…”

Practical Management of Iron Overload Disorder (IOD) in Black Rhinoceros (BR; Diceros bicornis)

“…Iron also plays an important catalytic role in free radical pathology and oxidative damage that is observed in almost all major iron loaded and non-iron loaded diseases such as cardiovascular, neurodegenerative, hepatic, and renal diseases, as well as in cancer and aging [52]. With chronicity in humans, iron deposition (hemosiderosis or secondary iron overload) will occur in the heart, brain, kidney, liver, joints, skin, and endocrine system [49,[53][54][55][56][57][58][59]. This chronic iron deposition in 60 BR necropsied was in the liver, spleen, bone marrow, and lungs, with some found in the small and large intestine, lymph nodes, and endocrine glands [2].…”

Normal black kidney

“…13 In another case, a 68-yearold non-diabetic male, with a history of metastatic colon cancer, was evaluated for a rising serum creatinine level after clinical evaluations and imaging; in this case, the renal hemosiderosis was considered the cause of the renal failure. 9 Lipofuscinoses occur due to abnormal accumulation of this pigment. 14,15 Pathologic lipofuscin can lead to blue kidney, 4 macular degeneration and other diseases.…”

“…This disorder is a disease, like sickle cell anemia and thalassemia, in which chronic blood loss requires frequent blood transfusions (though beta minor thalassemia has been associated with hemosiderin deposits in the liver in patients with non-alcoholic fatty liver disease independent of any transfusions). 7,8 Also, renal hemosiderosis is a complication of chronic intravascular hemolytic states, such as hemolytic anemia, paroxysmal nocturnal hemoglobinuria (PNH) and mechanical hemolysis after inserting a prosthetic cardiac valve 9,10 or black-water fever as well. 3 Renal hemosiderosis (blue kidney) is the anatomic indicator of severe intravascular hemolysis.…”