Renal histamine increases in the streptozotocin-diabetic rat

Markle, Ronald A.; Hollis, Theodore M.; Cosgarea, Andrew J.

doi:10.1016/0014-4800(86)90030-4

Cited by 28 publications

(13 citation statements)

References 19 publications

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“…AQP2 abundance in the apical membrane is strictly involved in the mechanisms for regulation of water reabsorption and urine concentration [10]. The ability to concentrate urine is impaired in conditions such as diabetes insipidus, Histamine, whose levels have been reported to be increased in the kidney of diabetic animals [2], has been shown to increase salt and water excretion [8][9][10]. Consistent with the observation that histamine induces AQP4 internalization in human AQP4-expressing gastric cells [11], we could speculate that H 3 R may subserve an AQP2 trafficking role in renal duct cells.…”

Section: Discussionmentioning

confidence: 99%

“…In renal transplant patients the urinary and blood levels of histamine are elevated. In the kidney of diabetic rats, histamine was increased compared with controls [2]. Basically, histamine has been reported to regulate the renal microcirculation, to increase salt and water excretion [3][4][5], decrease the ultrafiltration coefficient by reducing the total filtration surface area [4], and increase renin release [6].…”

Section: Introductionmentioning

confidence: 98%

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H3 receptor renal expression in normal and diabetic rats

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

H3 receptor renal expression in normal and diabetic rats

et al. 2015

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“…Antibodies H 3 R and H 4 R were detected by using the anti-hH 3 R (349-358) and the anti-hH 4 R (374-390) antibodies produced and validated for detecting both human and rodent H 3 R and H 4 R in the School of Biological and Biomedical Sciences, Durham University [21][22][23][24][25][26][27]. Briefly, anti-hH 3 R antibody was generated coupling the peptide corresponding to the amino acids RLSRDRKVAK Cys of the human and rat H 3 R to thyroglobulin by m-maleimidobenzoic acid N-hydroxysuccinimide ester coupling method as described previously [6] and antibodies were raised in rabbits to the resultant conjugate. Anti-peptide antibody production was monitored by enzyme-linked immunosorbent assay with the peptide H 3 (349-358) as the antigen.…”

Section: Reagentsmentioning

confidence: 99%

“…Moreover, some evidence suggest that histamine may be involved in diabetesrelated kidney disease. Indeed, in the kidney of diabetic rats, histamine was increased compared with controls [6,7]. Independent studies indicate that histamine regulates the renal microcirculation, by increasing salt and water excretion [8][9][10], decreasing the ultrafiltration coefficient by reducing the total filtration surface area [10], and increasing renin release [11].…”

Section: Introductionmentioning

confidence: 99%

Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation

et al. 2015

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Objective and design The aim of this study is to evaluate the expression of the histamine receptors, particularly focusing on the H 4 R in human renal tubules. MaterialThe ex-vivo evaluation was carried on specimens from human renal cortex. Primary and immortalized tubular epithelial cells (TECs) and the HK-2 cell line were used as in vitro models.Treatment Cells were pretreated for 10 min with chlorfeniramine maleate 10 µM (H 1 R antagonist), ranitidine 10 µM (H 2 R antagonist), GSK189254 1 µM (H 3 R antagonist) or JNJ7777120 10 µM (H 4 R antagonist), and then exposed to histamine (3 pM -10 nM) for 30 min. MethodsThe ex-vivo evaluation on specimens from human renal cortex was performed by immunohistochemistry. The expression of histamine receptors on primary and immortalized TECs and the HK-2 cell line was evaluated at both gene (RT-PCR) and protein (immunocytofluorescence) levels. The pharmacological analysis was performed by TR-FRET measurements of second messenger (IP3 and cAMP) production induced by histamine with or without the selective antagonists.Results Our data revealed the presence of all histamine receptors in human tubules; however, only TECs expressed all the receptors. Indeed, histamine elicited a sigmoid dose-response curve for IP 3 production, shifted to the right by chlorpheniramine maleate, and elicited a double bell-shaped curve for cAMP production, partially suppressed by the selective H 2 R, H 3 R and H 4 R antagonists when each added alone, and completely ablated when combined together.Conclusions Herein, we report the identification of all four histamine receptors in human renal tubules.

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“…Studies performed in streptozotocin (STZ) diabetic rats have shown, consistently with a generalized effect of diabetes on inducing an increase in histamine, a greater content of histamine in the kidney of diabetic animals than that of controls [6,7]. This increase has been related to a significantly greater tissue HDC activity of diabetic rats than controls without a concomitant decrease in histaminase activity [8], an enzyme that catalyzes the inactivation of histamine.…”

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confidence: 99%

Overexpression of histamine H4 receptors in the kidney of diabetic rat

Rosa

Grange²,

Pini

et al. 2012

Inflamm. Res.

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Objective and design: The renal expression of H 1 and H 2 receptors was previously demonstrated, while that of the H 4 receptor has been poorly investigated, thus the aim of this research was to investigate the expression of the H 4 receptor in the kidney of diabetic rats.Material or subjects: 24 8-week-old male Wistar rats Treatment: Diabetes was induced in 12 rats by a single i.v. injection of streptozotocin, and animals were sacrificed 6 weeks later.Methods: Kidneys were collected and processed for quantitative PCR or immunohistochemical analyses. To ascertain the renal topology of the H 4 receptor, colocalization experiments were performed with a series of markers.Results: H 4 receptor is expressed in healthy rats, although at a very low level, and is profoundly upregulated in diabetic animals. Immunohistochemical analysis revealed the highest immune-positivity in the medulla. Colocalization experiments revealed a close overlap in expression topology of the H 4 receptor and both Tamm-Horsfall glycoprotein and aquaporin 1 was observed.Conclusions: The results demonstrate, for the first time, that the H 4 receptor is expressed in the kidney mainly by resident renal cells of the loop of Henlé and that this receptor is significantly overexpressed in diabetic animals, thus suggesting a possible role in the pathogenesis of diabetes-associated renal disease.

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Renal histamine increases in the streptozotocin-diabetic rat

Cited by 28 publications

References 19 publications

H3 receptor renal expression in normal and diabetic rats

H3 receptor renal expression in normal and diabetic rats

Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation

Overexpression of histamine H4 receptors in the kidney of diabetic rat

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