Renal Histopathology of Leptospirosis Caused by Leptospira grippotyphosa in Farm Animals in Kenya

Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection

“…Recent data implicate strong cellular immune responses in protecting cattle against serovar Hardjo (Naiman et al, 2001(Naiman et al, , 2002Brown et al, 2003). Multinucleate giant cells have been reported in the kidneys of naturally infected cattle (Hadlow and Stoenner, 1955;Burdin, 1963;Amatredjo et al, 1976;Yener and Keles, 2001). Although some authors have implicated a foreign body reaction against degenerative tubules or their content, the recent observation of leptospiral antigen in those giant cells favours the interpretation that these ¢ndings re£ect a true response to persistent colonization (Yener and Keles, 2001).…”

Immunoperoxidase and Histopathological Examinations of Leptospiral Nephritis in Cattle

“…Syncytial and foreign body giant cells (Amatredjo et al., 1976), and syncytial and giant cells of Langhans’ type (Hadlow and Stoenner, 1955; Burdin, 1963) were reported in a kidney with focal non‐purulent interstitial nephritis in an animal with leptospirosis, diagnosed by culturing. Hadlow and Stoenner (1955) have suggested that these syncytial and multinucleated giant cells are derived from degenerative tubules.…”

“…According to cultural and/or serological evidence, the lesions of focal interstitial nephritis in adult cattle have been attributed to infections with L. interrogans (Hadlow and Stoenner, 1955; Burdin, 1963; Amatredjo et al., 1976; Prescott et al., 1987). In addition, Prescott et al.…”

“…In such cases, the disease is characterized by scattered, macroscopic greyish‐white foci (white‐spotted kidneys) in slaughtered cattle (Monaghan and Hannan, 1983; Skilbeck et al., 1988). The lesions of focal interstitial nephritis in adult cattle have been attributed to infections with Leptospira interrogans (Hadlow and Stoenner, 1955; Burdin, 1963; Amatredjo et al., 1976) based on cultural and/or serological evidence.…”

“…According to cultural and/or serological evidence, the lesions of focal interstitial nephritis in adult cattle have been attributed to infections with L. interrogans (Hadlow and Stoenner, 1955;Burdin, 1963;Amatredjo et al, 1976;Prescott et al, 1987). In addition, Prescott et al (1987) stated that leptospira could be isolated from kidneys with multiple gross lesions of nephritis, but there was no correlation between the presence of scant kidney lesions and isolations of leptospira.…”