Renal homotransplantation: the cytology of the urine sediment

Kline, Theresa; Craighead, John E.

doi:10.1097/00007890-196801000-00036

Cited by 5 publications

(6 citation statements)

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“…These lymphoid cells have a propensity to work their way between tubular cells into the tubular lumen where they accumulate in the urine together with tubular epithelial cells (Russell, 1968). The detection of these cells in the urine has attracted many investigators who have used either methylene blue (Kauffman, Clark, Magee, Rittenbury, Goldsmith, Prout, and Hume, 1964), or the Papanicolaou method (Kline and Craighead, 1967;Taft and Flax, 1966), or the May-Grunwald-Giemsa stain (Spencer and Petersen, 1967). We used the staining method of haematoxylin-eosin and had no difficulty in differentiating polymorphs from mononuclear cells.…”

Section: Discussionmentioning

confidence: 99%

“…Other investigators also suggested that the study of urinary sediment was a valuable guide to the fate of a transplanted kidney, especially when the urine was examined daily as a routine procedure (Calne, 1964 and Peart, 1965;Taft and Flax, 1966;Spencer and Petersen, 1967). Nevertheless, Kline and Craighead (1967) recently reported that cells diagnostic of immunological rejection of the homograft were not observed in their patients.…”

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confidence: 99%

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Clinical evaluation of the urinary sediment after renal allotransplantation

Papadimitriou¹,

Chisholm²,

Kulatilake³

et al. 1970

J Clin Pathol

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SYNOPSISThe detection of lymphoid cells by routine examination of the urine after renal allotransplantation has proved to be a useful early indication of rejection. In a study of 36 rejection episodes, 20 (56%) were associated with a significant number of lymphocytes in the urine. The incidence was much higher when rejection occurred during the first month after operation (76 %); lymphocytes were rarely found when rejection occurred after three months. The appearance of lymphocytes in the urine was of particular value for detecting rejection in patients with prolonged oliguria after transplantation.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Clinical evaluation of the urinary sediment after renal allotransplantation

Papadimitriou¹,

Chisholm²,

Kulatilake³

et al. 1970

J Clin Pathol

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“…Three studies [1,3,9] in which urine sediments were stained with methyl green showed lymphocyturia to be of diagnostic value. How ever, two other groups of investigators [10,11] using Papanicolaou staining, could not find a good correlation between lymphocyturia and transplant rejection. In the present study, we have attempted to clarify the role of lymphocyturia by using a simple staining technique on daily urine specimens.…”

Section: Discussionmentioning

confidence: 97%

Lymphocyturia: an Important Diagnostic and Prognostic Marker in Renal Allograft Rejection

Krishna¹,

Fellner²

1982

Am J Nephrol

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We examined the urine for lymphocytes in 60 renal allograft recipients in the immediate posttransplant period using a simple staining technique with methylene blue. 37 acute rejection episodes associated with deterioration in renal function were observed. Other causes of decreased renal function, such as acute tubular necrosis, vascular occlusion or urologic obstruction were carefully excluded. 34 (92%) of the 37 acute rejection episodes were accompanied by significant lymphocyturia. Lymphocyturia was recognized concomitantly with the rise in serum creatinine in 20 of the 34, whereas in 14 it preceded the rise in serum creatinine by a period of 3.5 ± 2.5 days. 24 (71 %) of the 34 acute rejection episodes were reversed by high dose steroid administration and only 2 of them showed persistent lymphocyturia following treatment. On the other hand, 9 of the 10 nonresponders to steroid therapy showed persistent lymphocyturia. All the nonresponders eventually required maintenance dialysis. Detection of lymphocyturia is not only of value in the diagnosis of acute allograft rejection, but is also useful in determining allograft survival in the immediate posttransplant period_.

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“…Fixed or unfixed urine has been obtained as fresh aliquots or as timed collections [30 -33, 48]. Slides have been prepared by direct smear [30,32,36,40], by filtration onto a membrane [31,34,35,39], and by cytocentrifugation [37,42,43]. Staining has been by the Papanicolaou method [31,32,34,35,37,39,40], WrightGiemsa [30], Prescott [49], or methyl green-pyronine [36].…”

Section: Preparation and Interpretation Of Specimensmentioning

confidence: 99%

Urine cytology: an underused method to diagnose acute renal allograft rejection

Corey

1997

Pediatric Nephrology

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In children, the early detection and accurate diagnosis of acute renal allograft rejection (AR) may be difficult. A delay in the diagnosis and treatment of AR might engender a poor outcome. Core needle biopsy is diagnostic but invasive. However, only a few less-invasive means to diagnose AR are sufficiently accurate to warrant their routine use. One such method is urine cytology. Investigators have demonstrated in more than 800 patients that urine cytology is simple and reliable for diagnosing graft failure. These observations may be important for children, for whom a non-invasive, accurate, and easily repeated indicator of AR may be particularly useful. While not a substitute for transplant biopsy, urine cytology may reduce diagnostic uncertainty and indicate the need for core needle sampling in a timely manner.

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Renal homotransplantation: the cytology of the urine sediment

Cited by 5 publications

References 0 publications

Clinical evaluation of the urinary sediment after renal allotransplantation

Clinical evaluation of the urinary sediment after renal allotransplantation

Lymphocyturia: an Important Diagnostic and Prognostic Marker in Renal Allograft Rejection

Urine cytology: an underused method to diagnose acute renal allograft rejection

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