2021
DOI: 10.3390/medicina57121348
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Renal Impairment Detectors: IGFBP-7 and NGAL as Tubular Injury Markers in Multiple Myeloma Patients

Abstract: Background and Objectives: Urine insulin-like growth factor-binding protein 7 (IGFBP-7), tissue inhibitor of matrix metalloproteinase 2 (TIMP-2), and neutrophil gelatinase-associated lipocalin (NGAL) monomer are novel tubular kidney injury biomarkers. In multiple myeloma (MM), immunoglobulin free light chains (FLCs) play an integral role in renal impairment. This study aimed to investigate the correlation between new biomarkers and acclaimed parameters of renal failure, MM stage, and prognosis. Materials and M… Show more

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Cited by 6 publications
(6 citation statements)
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“…Renal insufficiency is considered reversible in about 50% of cases in some reports [ 8 , 9 ]. With the advent of novel drugs (e.g., proteasome inhibitors), prognosis for MM patients with renal insufficiency has remarkably improved [ 7 , 11 , 12 , 13 , 14 , 15 , 16 ].…”
Section: Introductionmentioning
confidence: 99%
“…Renal insufficiency is considered reversible in about 50% of cases in some reports [ 8 , 9 ]. With the advent of novel drugs (e.g., proteasome inhibitors), prognosis for MM patients with renal insufficiency has remarkably improved [ 7 , 11 , 12 , 13 , 14 , 15 , 16 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, although in our study serum iron concentrations were correlated with renal function (serum creatinine, eGFR, and urine NGAL), we observed no such correlations in the case of serum ferritin, sTfR, and hepcidin. It is well known that renal impairment in MM reflects poor prognosis and determines the response to chemotherapy [ 3 ]. The lack of hepcidin correlation with renal function supports the role of hepcidin as a marker of poor prognosis in MM that is independent of renal injury.…”
Section: Discussionmentioning
confidence: 99%
“…It is often described as a “real-time indicator of renal injury”. It also shows a relationship with inflammation and tumor burden [ 3 , 41 , 42 , 43 , 44 ].…”
Section: Discussionmentioning
confidence: 99%
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“…The most widely used RI markers have significant flaws, including delayed onset after renal injury, multiple interfering variables, and lower sensitivity to minor alterations in glomerular filtration. 1 The kidneys filter urea, a waste product of protein breakdown in the liver, from the bloodstream and into the urine. The urea test determines how effectively the kidneys are functioning.…”
Section: Introductionmentioning
confidence: 99%