Renal Interstitial Fibrosis and Vascular Changes

Svenson, Karin L. G.

doi:10.1001/archinte.1986.00360220169028

Cited by 47 publications

(2 citation statements)

References 13 publications

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“…Svenson et al 12 did not consider arteriolopathy to be a major pathogenic factor inducing interstitial fibrosis, because focal interstitial fibrosis was observed without apparent arteriolar hyalinosis. In our patient, arteriolar hyalinosis was mild, and arteriolosclerosis was not found, so the contribution of hemodynamic factors to focal fibrosis could be ruled out in this patient.…”

Section: Discussionmentioning

confidence: 99%

Cyclosporine A-Mediated renal lesion in a child with intractable proteinuria

Nagasawa

Ehara

Kanemura³

et al. 1999

Clinical and Experimental Nephrology

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The histopathological observation of an 8-year-old boy who received cyclosporine A (CyA) for the treatment of persistent proteinuria is presented. In the renal biopsy specimen, typical CyA cytotoxic changes, such as juxtaglomerular apparatus hyperplasia and arteriolar hyalinosis, were observed. Electron microscopically, tubular epithelial cells and arteriolar smooth muscle cells were observed to have enlarged lysosomes, fine vacuoles, and/or enlargement and intracristal swelling of mitochondria. In the area of focal interstitial fibrosis, fibroblast-like cells (myofibroblasts) contained similar cytoplasmic vacuoles with a membranous substance. Although most vacuoles may have been formed due to dilatation of the endoplasmic reticulum, some vacuoles seemed to have originated from mitochondria or autolysosomes in tubular epithelial cells, smooth muscle cells, and fibroblast-like cells. These degenerative changes of organella may take part in the process that resulted in hyalinosis and interstitial fibrosis.

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Section: Discussionmentioning

confidence: 99%

Cyclosporine A-Mediated renal lesion in a child with intractable proteinuria

Nagasawa

Ehara

Kanemura³

et al. 1999

Clinical and Experimental Nephrology

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“…Methotrexate is also administered as an adjunct therapy, more so for patients who can't tolerate the side effects of high dose steroid therapy [39,40]. Other adjunctive therapeutic medications used in conjunction with steroids are Azathioprine, cyclophosphamide, Cyclosporin A, antiCD4 monoclonal antibodies and dapsone [41][42][43][44][45][46][47].…”

Section: Treatmentmentioning

confidence: 99%

Larngeal Manifestations of Relapsing Polychondritis

Hamdan¹,

Sarieddine

2013

OJRA

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The incidence of Relapsing Polychondritis is estimated to be 3.5 cases per million with only 600 cases being reported in the world. It can affect any age ranging from 5 to 84 years with predominance in the fourth and fifth decade. Male to female ratio varies from 1:1 to 1:3. It is believed to be an immunologic reaction to collagen Type II which is predominantly presented in the cartilaginous structures of the body and in the eye. The diagnosis is based on the presence of three or more clinical signs, one clinical sign in addition to histological confirmation, or involvement of two or more sites with a favorable response to treatment based on Mc Adam diagnostic criteria. The otolaryngologic manifestations of RP span the ears, nose, larynx and tracheobronchial tree. The symptoms include change in voice quality, respiratory discomfort, stridor, dyspnea, cough, chocking, anterior neck tenderness mainly over the thyroid cartilage and cricoid cartilages, aspiration and difficulty in swallowing. The laryngeal manifestations should be evaluated using high resolution computerized tomography, Magnetic resonance imaging, pulmonary function testing, plain radiography and pulmonary function testing.

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Ocular Penetration of Cyclosporine A in the Rat Eye

BenEzra

Maftzir²

1990

Arch Ophthalmol

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Renal Interstitial Fibrosis and Vascular Changes

Cited by 47 publications

References 13 publications

Cyclosporine A-Mediated renal lesion in a child with intractable proteinuria

Cyclosporine A-Mediated renal lesion in a child with intractable proteinuria

Larngeal Manifestations of Relapsing Polychondritis

Ocular Penetration of Cyclosporine A in the Rat Eye

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