Renal involvement in canine leishmaniasis: a morphological and immunohistochemical study

Soares, Maurílio J.; Moraes, Julieta Rodini Engrácia de; Moraes, Flávio Ruas de

doi:10.1590/s0102-09352009000400004

Cited by 9 publications

(9 citation statements)

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“…Regarding renal function, it is important to determine the degree of injury and the prognosis of dogs with leishmaniasis by assessing the levels of creatinine and urea 6 . The renal damage may also be attributed to deposits associated with the specific IgM and IgG antibodies 27 .…”

Section: Conflict Of Interest Financial Support Referencesmentioning

confidence: 99%

Clinical and laboratory alterations in dogs naturally infected by Leishmania chagasi

Freitas

Nunes-Pinheiro

Neto

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: Canine visceral leishmaniasis (CVL) is a zoonotic disease with different clinical manifestations. Parasitism often occurs in bone marrow, but changes have been observed in peripheral blood and serum biochemical parameters. The aim of this study was to evaluate the hematological and biochemical parameters in dogs naturally infected by Leishmania chagasi. Methods: Eighty-five adult dogs of both sexes and various weights and ages from the Zoonosis Control Center of Fortaleza (CCZ) were used, selected by immunofluorescence assay (IFA) and considered positive with IFA titers greater than 1:40 and by visualizing amastigotes of Leishmania chagasi in smears obtained by bone marrow aspiration. The dogs (n = 85) were grouped according to clinical signs: negative (CN = 7), subclinical (CS = 10), and clinical (CC = 68). Blood samples were collected for determination of hematological and biochemical serum values. The experimental protocol was approved by the CEUA/UECE. Results: The most frequent clinical signs were cachexia (77.9%), keratitis (61.8%), and lymphadenopathy (55.9%), and 86.8% of the animals showed more than one clinical sign characteristic of CVL. In CC were observed reductions in red blood cells (63%), hematocrit (72%), and hemoglobin (62%), as well as leukocytosis (33%), neutropenia (28%), thrombocytopenia (50%), uremia (45%), hyperproteinemia (53%, p<0.05), hypergammaglobulinemia (62%, p<0.01), and hypoalbuminemia (58%). Conclusions: Animals with the clinical form of the disease demonstrate hematological and biochemical changes consistent with anemia, uremia, hyperproteinemia, and hyperglobulinemia, which present themselves as strong clinical markers of visceral leishmaniasis associated with the signs previously reported. Keywords: Dogs. Canine visceral leishmanisis. Biomarkers. Anemia. Uremia. Hyperglobulinemia. RESUMO Introdução:A leishmaniose visceral canina (LVC) é uma zoonose com diferentes manifestações clínicas. O parasitismo ocorre frequentemente na medula óssea e têm sido relatadas alterações hematológicas e bioquímicas. Objetivou-se avaliar os parâmetros clínicos, hematológicos e bioquímicos de cães naturalmente infectados por Leishmania chagasi. Métodos: Utilizaram-se 85 cães adultos, ambos os sexos, peso e idade variados, oriundos do Centro de Controle de Zoonoses de Fortaleza, selecionados pela reação de imunofluorescência indireta (RIFI), sendo considerados positivos os animais com títulos de RIFI ≥ 1:40 e pelo exame parasitológico das formas amastigotas de Leishmania chagasi em esfregaços de medula óssea. Os cães foram agrupados conforme os sinais clínicos associados à doença: negativos (CN=7); subclínicos (CS=10) e clínicos (CC=68). Amostras de sangue foram coletadas para determinação dos parâmetros hematológicos e bioquímicos séricos. O protocolo experimental foi aprovado pelo CEUA/UECE, protocolo n° 08622833-1. Resultados: Os sinais clínicos mais frequentes foram caquexia (77,9%), ceratoconjuntivite (61,8%) e linfadenopatia (55,9%), sendo que 86, 8% dos animais aprese...

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Section: Conflict Of Interest Financial Support Referencesmentioning

confidence: 99%

Clinical and laboratory alterations in dogs naturally infected by Leishmania chagasi

Freitas

Nunes-Pinheiro

Neto

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…Immunoreactants may also be found within the glomeruli of clinically normal dogs without renal disease and this has been the case when control dogs were compared with dogs with leishmaniosis in some studies (Soares et al . 2009, Costa et al . 2010).…”

Section: What We Know About the Pathophysiology And Immunology Of Kidmentioning

confidence: 99%

Canine leishmaniosis and kidney disease: Q&A for an overall management in clinical practice

Roura

Cortadellas

Day

et al. 2020

J of Small Animal Practice

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“…Estas lesiones irreversibles dañan la nefrona y a medida que avanza la enfermedad, se disminuye la filtración glomerular, lo que resulta en insuficiencia renal y azotemia. De todos los mecanismos que cursan con glomerulopatías progresivas, las inmunomediadas son las más importantes, aunque en los casos de leishmaniasis aún no está totalmente definida su fisiopatología (16). Los animales infectados por el parásito muestran una serie de manifestaciones clínicas compatibles con diversas enfermedades lo cual hace aún más difícil que el Médico Veterinario sospeche en un primer momento de una infección por Leishmania.…”

Section: Presentación Clínica De La Leishmaniosis Caninaunclassified

“…These irreversible injuries cause damage to the nephrone and as the disease progresses, the glomerular filtration decreases, resulting in kidney failure and azotemia. Of all the mechanisms that cause progressive glomerulopathies, the immune-mediated are the most important; although in some cases of leishmaniasis, the pathophysiology has not been completely defined (16). Animals infected with the parasite show a series of clinical manifestations compatible with various diseases that make it more difficult for the Veterinary Doctor to suspect infection from Leishmania in a first instance.…”

Section: Presentación Clínica De La Leishmaniosis Caninamentioning

confidence: 99%

Canine Leishmaniosis: tools for diagnosis in veterinary practice in Colombia

B²,

B³

et al. 2015

Rev MVZ Córdoba

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The objective of this article is to perform a critical analysis and guide veterinarians in the management of canine Leishmaniosis. A systematic literature review was performed between 2005 and 2014 including scientific papers which take into account experiences and reports of: pathogenesis, diagnosis, clinical presentation, treatment, vaccination, prevention and control strategies. We discuss the different aspects of VL management and aspects that should be taken into account depending on the country, after a patient is suspected or confirmed as positive, including the possibility of euthanasia. We describe the different clinical manifestations of the disease, diagnosis, signs and treatment of canine leishmaniosis. Canine leishmaniosis is present in different parts of the country, therefore it must be considered as a possible differential diagnosis in the veterinary clinic, in patients with dermatological and systemic signs that are compatible with various diseases. In Colombia, the patients diagnosed with cutaneous leishmaniasis could be treated and have a favorable prognosis, whereas in canines with diagnosis of visceral leishmaniasis euthanasia should be considered because of the public health implications.Key words: Diagnosis differential, leishmania, reservoirs, zoonoses (Source: DeSC). RESUMENSe realiza un análisis crítico con el fin de orientar a los médicos veterinarios en el tema de Leishmaniosis canina. Se realizó una revisión de literatura a partir del año 2005 de manera sistemática considerando artículos científicos donde se tuvieran en cuenta experiencias y reportes de la patogenia, diagnóstico, presentación clínica de la enfermedad, tratamiento, la vacunación, el abordaje de los casos, estrategias de prevención y control y las consideraciones que se deben tener, según el país, ante la sospecha o confirmación de un paciente positivo, entre estos aspectos, la eutanasia. Se presentan las diferentes manifestaciones clínicas de la enfermedad, el diagnóstico, los signos y tratamiento de un paciente sospechoso para leishmaniosis canina, a manera de orientación para el profesional de la clínica veterinaria. La leishmaniosis canina se encuentra presente en diferentes partes del país, por lo que debe considerarse como posible diagnóstico diferencial en la clínica veterinaria, en pacientes con signos dermatológicos y sistémicos que son compatibles con diversas enfermedades. En Colombia, los pacientes diagnosticados con leishmaniosis cutánea podrían ser tratados y tener un pronóstico favorable, mientras que en los caninos con diagnóstico de leishmaniosis visceral debe considerarse la eutanasia por las implicaciones en salud pública.Palabras clave: Diagnóstico diferencial, leishmania, reservorios, zoonosis (Fuentes: DeSc). REVISIÓN DE LITERATURARev.MVZ Córdoba 20(3):4822-4842, 2015. ISSN: 0122-0268 4823 INTRODUCCIÓNLa Leishmaniosis es una enfermedad transmitida por vectores a los seres humanos y animales. Es causada por parásitos protozoarios del género Leishmania. Los caninos son susceptibles de adquir...

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Renal involvement in canine leishmaniasis: a morphological and immunohistochemical study

Cited by 9 publications

References 8 publications

Clinical and laboratory alterations in dogs naturally infected by Leishmania chagasi

Clinical and laboratory alterations in dogs naturally infected by Leishmania chagasi

Canine leishmaniosis and kidney disease: Q&A for an overall management in clinical practice

Canine Leishmaniosis: tools for diagnosis in veterinary practice in Colombia

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