Renal involvement in sarcoidosis

Lebacq, E; Verhaegen, H.; Desmet, VJ

doi:10.1136/pgmj.46.538.526

Cited by 80 publications

(49 citation statements)

References 9 publications

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“…[135][136][137] Activated macrophages in sarcoidal granulomas promote conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D. 17,130 Increased levels of 1,25-dihydroxyvitamin D increase intestinal absorption of calcium, bone resorption, and urinary calcium excretion. This impaired calcium regulation and hypercalciuria can result in nephrocalcinosis and nephrolithiasis.…”

Section: Systemic Manifestationsmentioning

confidence: 97%

Sarcoidosis

Sanchez

Haimovic

Prystowsky

2015

Dermatologic Clinics

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Sarcoidosis is a disease characterized by noncaseating granulomatous infiltration of 1 or more organs. In North America, after the lungs and thoracic lymph nodes, the skin is the next most commonly involved organ. Data from multiple studies indicate a coaction between genetic and environmental factors in immunologically susceptible hosts. The disease's many clinical manifestations and course vary greatly and are influenced by race, ethnicity, and gender. In the skin, the lesions of sarcoidosis are classified as specific when noncaseating granulomas are present, and nonspecific when there is an inflammatory reaction pattern devoid of granulomas.

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Section: Systemic Manifestationsmentioning

confidence: 97%

Sarcoidosis

Sanchez

Haimovic

Prystowsky

2015

Dermatologic Clinics

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“…Although this disorder mayinvolve the kidney in several ways (1), the precise prevalence of renal involvement is not known. However, more than 50%of patients with sarcoidosis have manifestations of renal dysfunction (2). Most commonly, derangements in vitamin D metabolism, such as hypercalcemia or nephrocalcinosis, are responsible for the renal manifestations of sarcoidosis.…”

Section: Introductionmentioning

confidence: 99%

A Patient with Sarcoidosis Presenting with Acute Renal Failure: Implication for Granulomatous Interstitial Nephritis and Hypercalcemia.

et al. 2002

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A womanwas admitted for acute renal failure and erythematous lesions. She was diagnosed with sarcoidosis after analysis of biopsy specimens revealed noncaseating epithelioid granulomas, elevated serum angiotensin-converting enzyme levels, and bilateral hilar lymphadenopathy. Serumconcentrations of ionized calcium and 1, 25-dihydroxyvitamin D3 [1, 25-(OH)2D3] were extremely high. Serumintact osteocalcin concentration and urinary deoxypyridinoline excretion were within reference ranges.Treatment with prednisolone induced a prompt improvement with normalization of serum concentrations of ionized calcium and 1, 25-(OH)2D3. Serum intact osteocalcin concentration was markedly suppressed and urinary deoxypyridinoline excretion increased. It is possible suppressed bone resorption may be associated with overproduction of 1, 25-(OH)2D3.

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“…(Yoshida and Okada, 1990) In course of chronic sarcoidosis, approximately 10-13.8% of patients have at least 1 asymptomatic stone. (Lebacq, 1970) Treatment of hypercalcuria involves minimization of dietary calcium and Vitamin D, avoidance of UV exposure, and dietary oxalate restriction. This is because an increase in intestinal calcium absorption caused by excess in 1, 25 dihydroxyvitamin D may result in an increase in urinary oxalate excretion especially if diet is low in calcium.…”

Section: Obstructive Nephropathymentioning

confidence: 99%