Renal lymph and its relationship to the countercurrent multiplier system of the kidney

Santos-Martinez, J.; Ee, Selkurt

doi:10.1152/ajplegacy.1969.216.6.1548

Cited by 5 publications

(2 citation statements)

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“…Bell et al (1968) have shown that medullary lymphatics probably do not exist in the dog kidney. However, since it has been suggested that medullary interstitial fluid is mixed with that coming from the cortex (Santos-Martinez & Selkurt, 1969), renal lymphatic obstruction may have increased medullary interstitial pressure by preventing the outflow of interstitial fluid from that area. If the effect of lymphatic obstruction is due to the increase in interstitial pressure around the tubules and is due to the change in the rate of bulkflow down the intercellular spaces (Nutbourne, 1968), it may have potentiated the effect of the diuretics in the ascending limb by suppressing the passive flow down the spaces of tubular fluid which had been released from the active reabsorption.…”

Section: E T H O D Smentioning

confidence: 99%

The Mechanism of Diuresis Caused by Renal Lymphatic Obstruction

et al. 1970

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1. The effect of renal lymphatic obstruction was studied by clearance methods with special reference to the renal response to the change in extra-cellular fluid (ECF) volume.2. When the left renal lymphatics of anaesthetized dogs were obstructed, E/C (experimental over control kidney) ratios of urine volume ( V ) and sodium excretion (U,,V) increased significantly in spite of constancy of GFR E/C. This effect occurred during nondiuresis, water diuresis and during distal blockade (i.e. tubular inhibition by thiazide and ethacrynic acid).3. As ECF was reduced by distal blockade, V and U, , V decreased rapidly in the control kidney, but only slightly in the experimental one, resulting in a sharp increase of V E/C and U,,V E/C. 4. The results indicate that intrarenal interstitial volume and/or pressure play an important role in sodium and water excretion and that it alters the renal response to a change in ECF volume.

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Section: E T H O D Smentioning

confidence: 99%

The Mechanism of Diuresis Caused by Renal Lymphatic Obstruction

et al. 1970

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“…Although LeBrie and Mayerson (4,6,7) found lymphplasma concentration ratios for Na + and Cl~ in canine capsular lymph to be significantly greater than 1, this finding was not substantiated by Swann et al (8), Keyl et al (9), or Santos-Martinez and Selkurt (10) for capsular or hilar lymph. On the other hand, Papp and Szalay (11) found lymph-plasma ratios greater than for Na + and Cl~ in hilar lymph, and in a continuation of their earlier work, Bell et al (12) reported an average hilar lymphplasma ratio for Na + of 1.05.…”

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confidence: 92%

Renal Hilar Lymph

O’Morchoe

O'Morchoe

Heney

1970

Circulation Research

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Renal lymph was collected from single hilar lymphatics in 58 anesthetized dogs (1) to study the mechanism by which lymph production is affected during diuresis and (2) to determine whether a medullary contribution to renal lymph could be defined by changes in the electrolyte concentration of hilar lymph with concomitant alterations in the concentration gradient of the renal medulla. When diuresis was induced by a solute load (mannitol), lymph flow increased by 25 to 300%. On the other hand, when diuresis was induced without such a solute load, lymph flow was either unaffected (mersalyl) or slightly reduced (furosemide). It was concluded that the effect of mannitol on renal lymph flow was mediated primarily through its general eSect on extracellular fluid rather than through any specific intrarenal consequence of the diuresis itself.Control hilar lymph-to-plasma concentration ratios for Na + (1.057 ± 0.040), Ch (1.129 ± 0.040) and Ca 2+ (0.770 ± 0.046) but not K+ (0.986 ± 0.086) were found to be significantly different from 1.0. Failure of mannitol diuresis to alter significantly the lymph-plasma ratios of Na + and Ch~ provided evidence that the high electrolyte concentrations of the inner medulla were not reflected in hilar lymph. The finding that furosemide abolished the lymph-plasma concentration difference for Na + and significantly reduced that for Ch was taken as evidence that the outer medulla was a significant source of renal hilar lymph. Received October 9, 1969. Accepted for publication February 3, 1970. from the decrease in thoracic duct lymph which followed cessation of renal lymph production (1, 2). This method is not, however, suitable for comparison of flow under differing conditions in the same animal, nor does it provide information on changes in the composition of renal lymph. To obtain such information in the present study, renal lymph was collected by cannulating single hilar lymphatics in dogs. ADDITIONALWhile there is evidence that the flow of renal lymph is augmented during the administration of certain diuretics (2-5), the mechanism by which this is brought about has not been studied. Since the infusion of a solute load itself can alter the general level of lymph formation throughout the body, it is apparent that the effect on lymph production by the kidney might not be a specific" consequence of

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