Renal macrophages monitor and remove particles from urine to prevent tubule obstruction

He, Jian; Cao, Yangyang; Zhu, Qian; Wang, Xinge; Cheng, Guo; Wang, Qiang; He, Rukun; Lu, Haoran; Weng, Yuancheng; Mao, Genxiang; Bao, Yizhong; Wang, Jing; Liu, Xiaoli; Han, Fei; Shi, Peng; Shen, Xiao Z.

doi:10.1016/j.immuni.2023.12.003

Cited by 13 publications

(1 citation statement)

References 85 publications

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“…Idiopathic CaOx stones frequently feature Randall's plaques on renal papillae surfaces; these plaques are composed of calcium phosphate crystals mixed with a protein-and lipid-rich organic matrix, associated with the presence of classically activated pro-inflammatory M1 macrophages and the downregulation of anti-inflammatory M2 macrophages in the surrounding renal tissue ( 53 ). Medulla macrophages in renal medullary tubules were recently found to spontaneously form protrusions, penetrate epithelial cells to 'sample' urine contents depending on integrin β1, and even migrate to the lumen and carry particles out with urine, suggesting that urine flushing is not the only mechanism of urinary tract particle removal ( 54 ). By inhibiting the activation of NADPH oxidase, the production of ROS, and the phosphorylation of p38 MAPK, M2 macrophages reduce oxidative stress damage and apoptosis in HK-2 cells, thereby reducing the formation of kidney stones ( 55 ).…”

Section: The Various Forms Of Cell Death and Urolithiasismentioning

confidence: 99%

Cell death‑related molecules and targets in the progression of urolithiasis (Review)

Wu,

Xue,

et al. 2024

Int J Mol Med

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Urolithiasis is a high-incidence disease caused by calcium oxalate (mainly), uric acid, calcium phosphate, struvite, apatite, cystine and other stones. The development of kidney stones is closely related to renal tubule cell damage and crystal adhesion and aggregation. Cell death, comprising the core steps of cell damage, can be classified into various types (i.e., apoptosis, ferroptosis, necroptosis and pyroptosis). Different crystal types, concentrations, morphologies and sizes cause tubular cell damage via the regulation of different forms of cell death. Oxidative stress caused by high oxalate or crystal concentrations is considered to be a precursor to a variety of types of cell death. In addition, complex crosstalk exists among numerous signaling pathways and their key molecules in various types of cell death. Urolithiasis is considered a metabolic disorder, and tricarboxylic acid cycle-related molecules, such as citrate and succinate, are closely related to cell death and the inhibition of stone development. However, a literature review of the associations between kidney stone development, metabolism and various types of cell death is currently lacking, at least to the best of our knowledge. Thus, the present review summarizes the major advances in the understanding of regulated cell death and urolithiasis progression.

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Section: The Various Forms Of Cell Death and Urolithiasismentioning

confidence: 99%

Cell death‑related molecules and targets in the progression of urolithiasis (Review)

Wu,

Xue,

et al. 2024

Int J Mol Med

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Facile‐Prepared Size‐Controllable Nanogels for Enhancing Bidirectional Translocation, Control Efficiency, and Security of Nanopesticide

Wu,

Wang,

Liu

et al. 2024

Adv Funct Materials

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Nanopesticides have been acknowledged by International Union of Pure and Applied Chemistry as a critical tool for revolutionizing future agricultural practices. However, the existing nanopesticides are often plagued by high costs, strict preparation conditions, uncontrollable size, and poor stability. Herein, taking the non‐systemic insecticide lambda‐cyhalothrin (LC) as a model pesticide, a series of LC‐loaded poly(octyl acrylate) nanogel formulations (LONFs) simultaneously featuring easy‐preparation, size‐controllable, and targeted delivery using microemulsion polymerization are developed. By adjusting the ratio of surfactants, the size of LONFs can be accurately designed to be 20, 50, 100, and 200 nm, exhibiting good stability under unconventional storage conditions (0 °C, 54 °C, ultraviolet radiation). Furthermore, reducing the particle diameter enhances the bidirectional translocation of LONFs in Vicia faba L., potentially reaching an optimal diameter (≈20 nm) for unique and rapid transport. LONFs increase the acute toxicity of LC to Aphis craccivora compared to conventional microemulsions (with a maximum reduction of 82.40% in LC50 at 24 h). Additionally, LONFs alter the lethal process of LC in human embryonic kidney 293T cells, with minimal cytotoxicity at a concentration of general application (40 mg L−1). This strategy simultaneously considers convenience, size controllability, and efficiency, providing a feasible method for the industrial development of nanopesticides.

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Osteogenic‐Like Microenvironment of Renal Interstitium Induced by Osteomodulin Contributes to Randall's Plaque Formation

Zhu,

Huang,

Gao

et al. 2024

Advanced Science

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Calcium oxalate (CaOx) kidney stones are common and recurrent, lacking pharmacological prevention. Randall's plaques (RPs), calcium deposits in renal papillae, serve as niduses for some CaOx stones. This study explores the role of osteogenic‐like cells in RP formation resembling ossification. CaP crystals deposit around renal tubules, interstitium, and blood vessels in RP tissues. Human renal interstitial fibroblasts (hRIFs) exhibit the highest osteogenic‐like differentiation potential compared to chloride voltage‐gated channel Ka positive tubular epithelial cells, aquaporin 2 positive collecting duct cells, and vascular endothelial cells, echoing the upregulated osteogenic markers primarily in hRIFs within RP tissues. Utilizing RNA‐seq, osteomodulin (OMD) is found to be upregulated in hRIFs within RP tissues and hRIFs following osteogenic induction. Furthermore, OMD colocalizes with CaP crystals and calcium vesicles within RP tissues. OMD can enhance osteogenic‐like differentiation of hRIFs in vitro and in vivo. Additionally, crystal deposits are attenuated in mice with Omd deletion in renal interstitial fibroblasts following CaOx nephrocalcinosis induction. Mechanically, a positive feedback loop of OMD/BMP2/BMPR1A/RUNX2/OMD drives hRIFs to adopt osteogenic‐like fates, by which OMD induces osteogenic‐like microenvironment of renal interstitium to participate in RP formation. We identify OMD upregulation as a pathological feature of RP, paving the way for preventing CaOx stones.

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Renal macrophages monitor and remove particles from urine to prevent tubule obstruction

Cited by 13 publications

References 85 publications

Cell death‑related molecules and targets in the progression of urolithiasis (Review)

Cell death‑related molecules and targets in the progression of urolithiasis (Review)

Facile‐Prepared Size‐Controllable Nanogels for Enhancing Bidirectional Translocation, Control Efficiency, and Security of Nanopesticide

Osteogenic‐Like Microenvironment of Renal Interstitium Induced by Osteomodulin Contributes to Randall's Plaque Formation

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