Renal Manifestations in Inflammatory Bowel Disease: A Cohort Study During the Biologic Era

Association between inflammatory bowel disease, nephrolithiasis, tubulointerstitial nephritis, and chronic kidney disease: A propensity score‐matched analysis of US nationwide inpatient sample 2016–2018

“…IBD can be further complicated by renal involvement 13 . Recently, there has been emerging interest in the potential relationship between IBD and CKD.…”

“…12 IBD can be further complicated by renal involvement. 13 Recently, there has been emerging interest in the potential relationship between IBD and CKD. Despite that previous studies appear to be conflicting, several mechanisms have been proposed regarding the possible linkage between CKD and IBD, including deposition of immunoglobulin (Ig) A in the glomerular basement membrane in so-called IgA nephropathy, 14 nephrotoxicity induced by 5-aminosalicylate (5-ASA) for the treatment of IBD, [15][16][17][18][19] kidney damage caused by extraintestinal manifestations (EIMs) of IBD, [20][21][22] ureteral obstruction caused by nephrolithiasis as a urinary manifestation of IBD, [23][24][25][26] inflammation induced by secondary amyloidosis, 27 and hypersensitivity to endogenous or exogenous antigens expressed by tubular cells in interstitial nephritis.…”

Kidney Diseases Associated With Inflammatory Bowel Disease: Impact of Chronic Histologic Damage, Treatments, and Outcomes

“…Kidney involvement has been described in 4% to 23% of patients with IBD and may be caused by several factors, including the primary systemic disease itself, secondary complications due to persistent chronic inflammation, malnutrition, dehydration episodes associated with intestinal losses, or drug-related side effects. 5 , 9 , 11 , 12 The most common causes of kidney injury in patients with IBD include urolithiasis, fistulas, and ureteral obstruction. 12 , 13 , 14 However, the spectrum of kidney diseases associated with IBD may be broader, including glomerular or interstitial diseases.…”

“… 12 , 13 , 14 However, the spectrum of kidney diseases associated with IBD may be broader, including glomerular or interstitial diseases. 11 , 12 The most common diagnosis described in a previous case series of 83 consecutive patients with IBD 15 included, IgAN, tubulointerstitial nephritis, arterio-nephrosclerosis, acute tubular necrosis, or podocytopathies with minimal change or focal segmental glomerulosclerosis lesions, among others. Kidney disease associated with IBD has a significant impact on patients’ quality of life and is associated with increased patient morbidity and even mortality.…”

“…Kidney disease associated with IBD has a significant impact on patients’ quality of life and is associated with increased patient morbidity and even mortality. 5 , 9 , 11 , 15 Despite this, kidney outcomes of these patients and their main predictors have scarcely been evaluated.…”