Renal Medullary Carcinoma in an Adolescent With Unknown Sickle Cell Trait

Noreña-Rengifo, Brian D; Ochoa-Gaviria, Jorge; Vélez-Escobar, Alejandro; Muñoz, Juan Pablo Dueñas; Riveros-Angel, Marcela

doi:10.7759/cureus.14473

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…A recent case report on avascular necrosis of the humeral heads in SCT is a patient with sickle cell-beta thalassemia disease, not SCT (3). A recent case report on renal medullary carcinoma in SCT (so says the title) turns out to be a boy with Hb SC disease, not SCT (4). I contacted the authors of both reports; one group ignored me, and the other group agreed their title is wrong.…”

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confidence: 99%

Sports Hematology and Other Sports Medicine Updates

Eichner

2024

Curr Sports Med Rep

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Section: My Concern About a Trend In Medical Publishingmentioning

confidence: 99%

Sports Hematology and Other Sports Medicine Updates

Eichner

2024

Curr Sports Med Rep

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“…Renal medullary carcinoma (RMC) is a rare primary renal malignancy typically affecting young males of African descent with sickle cell trait or other sickle hemoglobinopathies 1–3 . Definitive diagnosis of RMC can be challenging due to its nonspecific radiographic features, lack of localizing symptoms, and overlapping features with other primary renal malignancies.…”

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confidence: 99%

“…

Renal medullary carcinoma (RMC) is a rare primary renal malignancy typically affecting young males of African descent with sickle cell trait or other sickle hemoglobinopathies. [1][2][3] Definitive diagnosis of RMC can be challenging due to its nonspecific radiographic features, lack of localizing symptoms, and overlapping features with other primary renal malignancies. Due to the inherently aggressive nature of RMC, most patients present with metastatic disease involving regional lymph nodes, the liver, lungs, bones, and/or adrenal glands and consequently face poor overall survival (OS).

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Diagnostic challenges of renal medullary carcinoma and the role for cytologic assessment: Case report and literature review

Severseike

Schafernak

Willard

et al. 2023

Clinical Laboratory Analysis

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Background Renal medullary carcinoma (RMC) is a diagnostically challenging, aggressive primary renal malignancy associated with abysmal survival. Delays in diagnosis contribute to most patients having diffusely metastatic disease at the time of initial presentation. Methods We present the case of a 13‐year‐old African American male with sickle cell trait who presented with a renal mass and hematuria. Evaluation included imaging, fluid cultures, and cytologic assessment. Results Patient was diagnosed with RMC based on cytologic assessment of sub‐centimeter fluid collections aspirated from the left kidney at the time of cortical biopsy for suspected renal mass. The additional fluid aspiration in conjunction with renal biopsy was an atypical but crucial step in early diagnosis. Conclusion Cytomorphologic evaluation of fluid biospecimens is not currently part of the standard work‐up for patients with renal masses but, when available, can provide crucial information that reduces time to diagnosis. Prompt symptom recognition and treatment initiation may improve patient outcomes.

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MRI Characteristics of Pediatric and Young-Adult Renal Cell Carcinoma: A Single-Center Retrospective Study and Literature Review

Beek

Krijger

Nievelstein

et al. 2023

Cancers

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Pediatric renal cell carcinoma (RCC) is a rare malignancy. Magnetic resonance imaging (MRI) is the preferred imaging modality for assessment of these tumors. The previous literature has suggested that cross-sectional-imaging findings differ between RCC and other pediatric renal tumors and between RCC subtypes. However, studies focusing on MRI characteristics are limited. Therefore, this study aims to identify MRI characteristics of pediatric and young-adult RCC, through a single-center case series and literature review. Six identified diagnostic MRI scans were retrospectively assessed, and an extensive literature review was conducted. The included patients had a median age of 12 years (63–193 months). Among other subtypes, 2/6 (33%) were translocation-type RCC (MiT-RCC) and 2/6 (33%) were clear-cell RCC. Median tumor volume was 393 cm3 (29–2191 cm3). Five tumors had a hypo-intense appearance on T2-weighted imaging, whereas 4/6 were iso-intense on T1-weighted imaging. Four/six tumors showed well-defined margins. The median apparent diffusion coefficient (ADC) values ranged from 0.70 to 1.20x10−3 mm2/s. In thirteen identified articles focusing on MRI characteristics of MiT-RCC, the majority of the patients also showed T2-weighted hypo-intensity. T1-weighted hyper-intensity, irregular growth pattern and limited diffusion–restriction were also often described. Discrimination of RCC subtypes and differentiation from other pediatric renal tumors based on MRI remains difficult. Nevertheless, T2-weighted hypo-intensity of the tumor seems a potential distinctive characteristic.

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Renal Medullary Carcinoma in an Adolescent With Unknown Sickle Cell Trait

Abstract: Noreña-Rengifo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cited by 3 publications

References 11 publications

Sports Hematology and Other Sports Medicine Updates

Sports Hematology and Other Sports Medicine Updates

Diagnostic challenges of renal medullary carcinoma and the role for cytologic assessment: Case report and literature review

MRI Characteristics of Pediatric and Young-Adult Renal Cell Carcinoma: A Single-Center Retrospective Study and Literature Review

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