1995
DOI: 10.1097/00000478-199501000-00001
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Renal Medullary Carcinoma The Seventh Sickle Cell Nephropathy

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Cited by 526 publications
(352 citation statements)
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“…Mariñ o-Enríquez et al 2 classified their tumor as renal medullary carcinoma (RMC); we 1 did not label ours as RMC because it lacked extreme clinical aggressiveness characteristic of RMC. 8,9 Retention of INI1 by immunohistochemistry was also not in favor of RMC. 10 In a retrospect, both pediatric cases shared all clinicopathologic characteristics and the same VCL-ALK fusion.…”
mentioning
confidence: 79%
“…Mariñ o-Enríquez et al 2 classified their tumor as renal medullary carcinoma (RMC); we 1 did not label ours as RMC because it lacked extreme clinical aggressiveness characteristic of RMC. 8,9 Retention of INI1 by immunohistochemistry was also not in favor of RMC. 10 In a retrospect, both pediatric cases shared all clinicopathologic characteristics and the same VCL-ALK fusion.…”
mentioning
confidence: 79%
“…6 Patients with sickle cell trait have a higher incidence of gross hematuria than patients with sickle cell disease. 2 The gross hematuria can be painless and is thought to arise from bleeding immediately beneath the renal pelvic epithelium 2 or as a result of papillary necrosis. 6 It involves the left kidney in Ͼ80% of patients.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, a new entity, renal medullary carcinoma, has been described in young people, including children, with sickle cell disorders. 2 Many of the reported cases have been diagnostic challenges with poor prognoses. It is unclear whether earlier diagnosis and earlier treatment will result in a better prognosis, but awareness of this newly described entity is most important.…”
mentioning
confidence: 99%
“…Renal medullary carcinoma (RMC) is a very rare form of RCC, which predominantly affects AfricanAmerican children and young adults with sickle cell trait or sickle cell disease [70,71]. Patients present clinically with high stage tumor and succumb to disease within a few weeks to months.…”
Section: Clinical Presentationmentioning
confidence: 99%