Renal, metabolic and hormonal responses to ingestion of animal and vegetable proteins

Abstract

Renal and hormonal responses were studied in a group of healthy individuals fed, in random order, for three weeks, a vegetable protein diet (N = 10), an animal protein diet (N = 10), or an animal protein diet supplemented with fiber (N = 7), all containing the same amount of total protein (chronic study). In seven additional subjects the acute renal, metabolic and hormonal response to ingestion of a meat or soya load of equivalent total protein content was investigated (acute study). In the chronic study GRF, RPF and fractional clearance of albumin and IgG were significantly higher on the animal than the vegetable protein diets (GFR: 121 +/- 4 vs. 111 +/- 4 ml/min/1.73 m2, P less than 0.001; RPF: 634 +/- 29 vs. 559 +/- 26 ml/min/1.73 m2, P less than 0.001; theta alb: 19.5 +/- 3.1 vs. 10.2 +/- 1.6 x 10(-7), P less than 0.01; theta IgG: 11.6 +/- 3.1 vs. 7.5 +/- 1.7 x 10(-7), P less than 0.05). Renal vascular resistance was lower on the animal than vegetable protein diet (82 +/- 5 vs. 97 +/- 5 mmHg/min/liter; P less than 0.001). Fiber supplementation to APD did not have any effect on the renal variables measured which were indistinguishable from APD. In the acute study, GFR and RPF both rose significantly by approximately 16% (P less than 0.005) and approximately 14% (P less than 0.05), respectively, after the meat load, while RVR fell by approximately 12% (P less than 0.05). There were no significant changes in these parameters following the soya load.(ABSTRACT TRUNCATED AT 250 WORDS)

Recommendations for the nutritional management of patients with diabetes mellitus

“…Evidence exists that proteins from differing sources may have unique properties and different effects on the progression of renal disease, with bene®ts claimed for vegetable proteins (Quinn, 1993;Kontessis et al, 1990). It is still not clear whether the protein quality or some other related factor, such as dietary ®bre or reduced intake of saturated fat, may be responsible for such effects.…”

Dietary soya protein during pregnancy and lactation in rats with hereditary kidney disease attenuates disease progression in offspring

“…Dietary manipulation with a vegetarian soya diet for as little as 8 or 16 weeks in nephrotic patients decreases proteinuria and vegetarians exhibit lower glomerular filtration rates than omnivores (Bosch et al 1983;Kontessis et al 1990;Barsotti et al 1991;D'Amico et al 1991;Gentile et al 1993). In diabetic patients, soya protein interventions have been shown to reduce glomerular hyperfiltration, proteinuria or albuminuria (Jibani et al 1991;Azadbakht et al 2003;Teixeira et al 2004;Stephenson et al 2005).…”

A Low-Iron-Available, Polyphenol-Enriched, Carbohydrate-Restricted Diet to Slow Progression of Diabetic Nephropathy

“…Second, not all proteins have the same renal effects. For example, in normal (16), dyslipidemic (17), and diabetic humans (18) ingestion of vegetable protein did not increase glomerular filtration rate (GFR), leading to hyperfiltration. Furthermore, some plant foods have advantageous properties, apparently unrelated to macronutrient composition.…”