Renal neoplasm in acquired cystic kidney disease

Acquired cystic disease-associated renal tumors: an immunohistochemical and fluorescence in situ hybridization study

“…[1][2][3] Clinically, these tumors differ from the sporadic variants with a younger age of presentation, greater frequency of multicentricity and bilaterality, and possibly an overall better prognosis. [1][2][3][4][5][6][7] Different types of renal cell epithelial neoplasms have been described in association with end-stage renal disease, with a high prevalence of papillary renal cell carcinomas and clear-cell renal carcinomas.…”

“…[1][2][3] Clinically, these tumors differ from the sporadic variants with a younger age of presentation, greater frequency of multicentricity and bilaterality, and possibly an overall better prognosis. [1][2][3][4][5][6][7] Different types of renal cell epithelial neoplasms have been described in association with end-stage renal disease, with a high prevalence of papillary renal cell carcinomas and clear-cell renal carcinomas. 1,3,4,[7][8][9][10][11][12] However, tumors arising in end-stage renal diseases, especially in association with acquired cystic disease, may also show distinctive histologic features not easily referable to the categories described in the current WHO classification system.…”

Heterochronic Spontaneous Rupture of Bilateral Renal Cell Carcinomas in a Hemodialysis Patient

“…Approximately 80% of RCCs in hemodialysis patients are related to ACDK. ACDK-related RCCs are prone to be multi-centric (9), and approximately 10% of patients who develop RCCs based on ACDK subsequently develop RCCs in the contralateral side (10). Some urologists propose the use of preventive surgery to treat RCCs; however, others prefer to avoid preventive surgery because RCC resection is invasive and bilateral nephrectomy occasionally leads to uncontrollable persistent hypotension after surgery.…”

Renal cell carcinoma of the native kidney in a renal transplant recipient

“…Chronic renal failure (particularly in patients on maintenance dialysis) is frequently associated with the development of multiple and bilateral renal cysts [2,3]. There is conflicting data on whether to screen patients with advanced kidney disease for acquired cystic disease and thereby early detection of premalignant or malignant lesions [4][5][6]. Current major guidelines do not recommend routine screening of average risk patients for renal cell carcinoma.…”