Renal Neoplasms of Childhood

Geller, Evan; Kochan, Polly S.

doi:10.1016/j.rcl.2011.05.003

Cited by 51 publications

(46 citation statements)

References 89 publications

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“…Sonographically, CMN can be a homo-or heterogeneous solid renal mass without a well-defined capsule [2,7] . Classic CMN presents as a hypoechoic tumor with an echogenic rim [8] . Color Doppler may show a ring of venous and arterial waveforms and/or low vascularity.…”

Section: Discussionmentioning

confidence: 99%

Contribution of Magnetic Resonance Imaging to Prenatal Differential Diagnosis of Renal Tumors: Report of Two Cases and Review of the Literature

Linam

Yu²,

Calvo-Garcia³

et al. 2010

Fetal Diagn Ther

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Enlargement of a kidney on prenatal imaging is usually due to hydronephrosis or cystic renal disease, and much less often results from solid tumors such as mesoblastic nephroma, Wilms’ tumor, nephroblastomatosis, renal sarcoma, and angiomyolipoma. All can be diagnosed by ultrasound. Magnetic resonance imaging is useful not only in confirming the presence of a renal mass, but also in the evaluation of the contralateral kidney for subtle abnormalities. We present one case each of Wilms’ tumor and mesoblastic nephroma, both detected on antenatal ultrasound and further studied with fetal magnetic resonance imaging.

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Section: Discussionmentioning

confidence: 99%

Contribution of Magnetic Resonance Imaging to Prenatal Differential Diagnosis of Renal Tumors: Report of Two Cases and Review of the Literature

Linam

Yu²,

Calvo-Garcia³

et al. 2010

Fetal Diagn Ther

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“…A key prognostic factor is the clinical stage of the disease at the time of diagnosis. Metastatic RCC is present in 20-30% of patients at diagnosis, with the majority of these demonstrating multiple metastatic sites (8,9). It has been established that RCC can invade the renal vein and extend to the inferior vena cava.…”

Section: Discussionmentioning

confidence: 99%

Mediastinal lymph node metastasis of renal cell carcinoma: A case report

et al. 2016

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Abstract. Renal cell carcinoma (RCC) may metastasize to mediastinal lymph nodes without any abdominal lymph node involvement. The present study describes an autopsy-proven case of RCC presenting with a large mediastinal mass; the case had been previously misdiagnosed as small cell lung carcinoma due to imaging analysis results, an elevated serum level of neuron-specific enolase and the presence of small atypical cells with a high nuclear/cytoplasmic ratio. Despite RCC occurrence being rare, it should be considered in the differential diagnosis, particularly when a mass located in the kidneys presents with metastases to the mediastinal lymph nodes, even if there is no involvement of the abdominal lymph nodes and the primary lesion is of a small size. IntroductionRenal cell carcinoma (RCC) accounts for 95% of renal neoplasms and ~3% of adult malignancies (1). In the United States, ~61,560 patients with RCC were identified and 14,080 patients were predicted to have succumbed to the disease in 2015 (2). Generally, patients with RCC present with gross hematuria, flank pain and a palpable mass; however, these symptoms are not always present. RCC is a heterogeneous disease and several histological subtypes have been categorized according to the 2004 World Health Organization (WHO) renal tumor classification (3). The mortality rate of patients with RCC depends on the histological subtype and the clinical stage of the tumor. Since RCC has a hemorrhagic tendency, biopsy of the tumor is disputed (4). A diagnosis of RCC is provided according to the results observed using imaging methodologies, including computed tomography (CT), and a diagnosis of RCC is confirmed by the surgical removal of the tumor en bloc. The present study reports the case of a patient who presented with a large, right mediastinal mass appearing to mimic small cell lung cancer (SCLC); however, following autopsy examination, the diagnosis was confirmed as RCC. Case reportA 56-year-old male presented at the Ryugasaki Saiseikai Hospital (Ryugasaki, Japan) in September 2011 with a dry cough that had persisted for 3 months. Physical examination identified decreased breath sounds at the right hemithorax. Laboratory evaluations were undertaken and included urinalysis and testing of blood urea nitrogen, creatinine and serum calcium concentrations. All laboratory analyses were normal, with the exception of an increased concentration of white blood cells (12,100 cells/µl; normal range, 3,900-9,800 cells/µl), C-reactive protein (12.9 mg/dl; normal range, 0.0-0.3 mg/dl) and serum neuron-specific enolase (NSE; 50.0 ng/ml; normal range, 0.0-16.3 ng/ml). Following a CT scan of the chest, a large mass was detected at the right mediastinum, extending directly to the heart, with the presence of pericardial fluid (Fig. 1). Pleural fluid was identified in the right hemithorax, but no abnormalities were observed in the lungs and the abdominal lymph nodes were not swollen. However, a small nodule was detected in the upper pole of the right kidney. A bronchoscopy was performe...

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“…[1] Approximately 12% of patients with WT have an underlying predisposing syndrome, such as incomplete orchiocatabasis, hypospadias, hemihypertrophy, and aniridia. [2] The vast majority of WT present with smooth surface asymptomatic abdominal mass, but substantial, without apparent tenderness on the side of the abdomen hypochondrium. Abdominal discomfort, irritability, shortness of breath, even the symptoms of acute abdomen may occur when the mass grows rapidly.…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%