Renal Neuroendocrine Neoplasms: A Single-center Experience

McGarrah, Patrick Walsh; Westin, Gustavo Figueiredo Marcondes; Hobday, Timothy J.; Scales, Joseph; Ingimarsson, Johann P.; Leibovich, Bradley C.; Halfdanarson, Thorvardur R.

doi:10.1016/j.clgc.2019.11.003

Cited by 16 publications

(39 citation statements)

References 24 publications

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“…Other theories regarding the origin of abnormal neuroendocrine cells within the kidney include metaplasia of the pyelocaliceal urothelium by chronic inflammation, metastasis from undiscovered primary tumours or entrapped neural crest tissue in the kidney during embryogenesis [ 13 ]. An association of NENs forming within abnormal renal tracts, such as horseshoe kidneys, has been described [ 3 , 5 , 13 ], but of note, the case that we describe here was of a tumour in an otherwise normal kidney with a normal contralateral kidney in situ.…”

Section: Discussionmentioning

confidence: 64%

“…Primary renal NENs form just a tiny fraction of all primary renal tumours, estimated at less than 0.3% [ 11 ]. Analysis of the SEER registry by McGarrah et al suggested that the incidence of primary renal NENs is 0.13 per one million persons [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…A significant number present asymptomatically, but for those with symptoms, flank or abdominal pain (with or without haematuria) are the most common [ 6 , 13 , 11 ]. Presentation with carcinoid syndrome or features of neuroendocrine crisis is rare, and most renal NENs are not found to be biochemically active [ 5 , 12 ]. On retrospective questioning, our patient did report some mild flushing episodes prior to diagnosis, but no diarrhoeal symptoms, and haematuria was not present despite the obliteration of the normal sinus architecture on microscopy.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Rare Case of a Large Primary Renal Neuroendocrine Tumour: A Case Report and Brief Review of Literature

Deacon¹,

Harvey²,

Shah³

et al. 2021

Cureus

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Rare Case of a Large Primary Renal Neuroendocrine Tumour: A Case Report and Brief Review of Literature

Deacon¹,

Harvey²,

Shah³

et al. 2021

Cureus

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“…31 In symptomatic patients, abdominal pain is the most common presenting symptom, followed by haematuria, abdominal mass, and constitutional symptoms such as weight loss and fever. 1,[11][12][13][14]16,17,24,27,[30][31][32][33][37][38][39][40][41][42][43][44][45][46]48,49 Although multiple other series have also noted an increased incidence of renal NEN in the right kidney some with higher proportions than others, 14,21,32,35,36 there are several included studies reporting relatively similar rates in each kidney. 12,18,31,32…”

Section: Clinical Presentationmentioning

confidence: 97%

Primary renal neuroendocrine neoplasms: A systematic literature review, report of four local cases, and original survival analysis of 63 patients from a national registry 2012–2018

Paisey

Weerasuriya

Palmer

et al. 2022

J Neuroendocrinology

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Primary renal neuroendocrine neoplasms (NEN) are rare. We aimed to conduct a systematic review, present local cases, and analyse data from the England's National Cancer Registration and Analysis Service (NCRAS) to provide comprehensive evidence on clinical experience, incidence, and survival to better characterize these tumours. First, a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method; second, a synthesis of local cases; and, finally, a retrospective population-based cohort analysis of renal NEN recorded between 2012 and 2018 on NCRAS were performed. Kaplan-Meier estimator was used to calculate overall survival and Cox proportional hazard regression to identify prognostic factors. Systematic review identified 48 articles and the evidence was summarized and presented. We reported data from four local cases presenting with abdominal and back pain but without carcinoid syndrome. In population-based analysis, we identified 63 cases of renal NEN between 2012 and 2018 from the registry. Age-standardized incidence was 0.09-0.32 per million with a median age of 64 years (interquartile range = 48-72 years). Survival was worse in males and those aged 64 years and over. Five-year survival for renal neuroendocrine tumours (NET) was 69.8% (95% confidence interval = 66.6-72.7) and neuroendocrine carcinomas (NEC) was 38.4% (95% confidence interval = 34.6-42.0). No independent predictive factor was identified in the multivariable analyses. We have given a systematic review of evidence, published local experience, and reported incidence and survival of renal NEN in England for the first time. We have provided clinicians with evidence on diagnosis and proposed a treatment algorithm of theses rare tumours. The incidence and median age of presentation in England is similar to other published series. Renal NET has better survival than renal NEC as expected. A uniform classification system would reduce inconsistencies in reporting and standardize treatment decisions for this neoplasia.

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“…Renal NENs have higher survival rates than poorly differentiated renal NENs [3]. Age > 40 years, tumor size > 4 cm, extrarenal tumor invasion, purely solid surface, and >1 mitoses per HPF are the poor prognostic factors in patients with renal NENs [9,10,61]. In the presence of horseshoe kidneys, the carcinoids manifest indolent behavior [12,33,62].…”

Section: Prognosis and Managementmentioning

confidence: 99%

Neuroendocrine Neoplasms of the Female Genitourinary Tract: A Comprehensive Overview

Virarkar

Vulasala

Gopireddy

et al. 2022

Cancers

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Primary neuroendocrine neoplasms are a rare heterogeneous group of tumors that include well-differentiated neuroendocrine tumors, poorly differentiated neuroendocrine carcinoma, and paraganglioma. An extensive literature search was used to compile the data regarding epidemiology, pathogenesis, imaging features, and management of the urinary system NENs. We also included the updated staging of the NENs at various locations of the urinary system.

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Renal Neuroendocrine Neoplasms: A Single-center Experience

Cited by 16 publications

References 24 publications

A Rare Case of a Large Primary Renal Neuroendocrine Tumour: A Case Report and Brief Review of Literature

A Rare Case of a Large Primary Renal Neuroendocrine Tumour: A Case Report and Brief Review of Literature

Primary renal neuroendocrine neoplasms: A systematic literature review, report of four local cases, and original survival analysis of 63 patients from a national registry 2012–2018

Neuroendocrine Neoplasms of the Female Genitourinary Tract: A Comprehensive Overview

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