Renal Oncocytoma and Cromophobe Renal Cell Carcinoma: Main Morphological Differences and Proposal of a Simple Histochemical and Immunohistochemical Panel to separate them

Ivan, Gallegos; Gonzalo, Carrasco; Fern,; Cristina, ez; Octavio, Castillo; Valdevenito, Raúl

doi:10.4172/2161-0681.1000195

Cited by 1 publication

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“…In the study by Ivan G et al (n=38), 18 cases of oncocytoma and 20 cases of chromophobe RCC on histopathological examination were evaluated using special stain and immunohistochemistry. On this basis, he reclassified one case of chromophobe RCC as granular variant of clear cell RCC, two cases of atypical oncocytoma as chromophobe RCC and 2 cases of oncocytoma were reclassified as chromophobe RCC [11] . Chromophobe RCC especially with eosinophilia variant can also be confused with oncocytoma.…”

Section: Discussionmentioning

confidence: 99%

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Histopathological spectrum of renal Neoplasms and tumor like lesion in a tertiary care center

Mangaiyarkarasi¹,

Shivashekar²,

John³

2020

Int. J. Clin. Diagn. Pathol.

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Introduction: Renal neoplasms are tumors that arise in renal tubular epithelium. These tumors account for about 2% of all cancer deaths. Benign renal neoplasm and tumor like conditions overlap with the malignant tumors. Accurate diagnosis is important for the treatment and prognosis of the patients. Aim: To study histopathology of renal neoplasms and tumor like lesions. To differentiate malignant renal neoplasms from benign and tumor like conditions. Materials and Methods: This retrospective study includes 31 cases admitted in our hospital. Patients who underwent nephrectomy for renal masses were enrolled in the study. Clinical data was obtained, grossing of the nephrectomy specimens and histological examination was done. Immunohistochemistry markers were used wherever necessary. Results: Out of 31 cases studied, 21 were malignant, 3 were benign and 7 were categorized into tumor like conditions. The Panel of IHC markers used in this study were (CD 10, CK 7, CD 117).

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Section: Discussionmentioning

confidence: 99%

“…The ISUP grading system is not applicable for this type of RCC. It has a favorable prognosis and is associated with Birt-Hogg-Dube syndrome [11] . Out of 24 renal neoplasms, 3 cases (33.3%) were Oncocytoma.…”

Section: Discussionmentioning

confidence: 99%